دورية أكاديمية
أعرض في EDS

An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure.

التفاصيل البيبلوغرافية
العنوان: An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure.
المؤلفون: Xu J; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Choi R; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Gupta K; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Warren HR; Centre of Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Santhanam L; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Pluznick JL; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
المصدر: Science advances [Sci Adv] 2024 Mar 22; Vol. 10 (12), pp. eadk1487. Date of Electronic Publication: 2024 Mar 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
مواضيع طبية MeSH: Renin* , Receptors, Odorant*/genetics, Mice ; Animals ; Female ; Male ; Humans ; Blood Pressure/physiology ; Sex Characteristics ; Pulse Wave Analysis
مستخلص: Sex differences in blood pressure are well-established, with premenopausal women having lower blood pressure than men by ~10 millimeters of mercury; however, the underlying mechanisms are not fully understood. We report here that sex differences in blood pressure are absent in olfactory receptor 558 knockout (KO) mice. Olfr558 localizes to renin-positive cells in the kidney and to vascular smooth muscle cells. Female KOs exhibit increased blood pressure and increased pulse wave velocity. In contrast, male KO mice have decreased renin expression and activity, altered vascular reactivity, and decreased diastolic pressure. A rare OR51E1 (human ortholog) missense variant has a statistically significant sex interaction effect with diastolic blood pressure, increasing diastolic blood pressure in women but decreasing it in men. In summary, our findings demonstrate an evolutionarily conserved role for OLFR558/OR51E1 to mediate sex differences in blood pressure.
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المشرفين على المادة: EC 3.4.23.15 (Renin)
0 (Receptors, Odorant)
0 (Olfr558 protein, mouse)
تواريخ الأحداث: Date Created: 20240320 Date Completed: 20240322 Latest Revision: 20240323
رمز التحديث: 20240323
مُعرف محوري في PubMed: PMC10954203
DOI: 10.1126/sciadv.adk1487
PMID: 38507492
قاعدة البيانات: MEDLINE
الوصف
تدمد:2375-2548
DOI:10.1126/sciadv.adk1487