دورية أكاديمية
أعرض في EDS

The interaction between lncRNAs and transcription factors regulating autophagy in human cancers: A comprehensive and therapeutical survey.

التفاصيل البيبلوغرافية
العنوان: The interaction between lncRNAs and transcription factors regulating autophagy in human cancers: A comprehensive and therapeutical survey.
المؤلفون: Jasim SA; Medical Laboratory Techniques Department, Al-Maarif University College, Anbar, Iraq., Almajidi YQ; Department of Pharmacy (Pharmaceutics), Baghdad College of Medical Sciences, Baghdad, Iraq., Al-Rashidi RR; Department of Dentistry, Kut University College, Wasit, Iraq., Hjazi A; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia., Ahmad I; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia., Alawadi AHR; College of Technical Engineering, The Islamic University, Najaf, Iraq.; College of Technical Engineering, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.; College of Technical Engineering, The Islamic University of Babylon, Babylon, Iraq., Alwaily ER; Microbiology Research Group, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq., Alsaab HO; Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, Saudi Arabia., Haslany A; Medical Technical College, Al-Farahidi University, Baghdad, Iraq., Hameed M; Medical Technical College, Al-Farahidi University, Baghdad, Iraq.
المصدر: Cell biochemistry and function [Cell Biochem Funct] 2024 Mar; Vol. 42 (2), pp. e3971.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8305874 Publication Model: Print Cited Medium: Internet ISSN: 1099-0844 (Electronic) Linking ISSN: 02636484 NLM ISO Abbreviation: Cell Biochem Funct Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, England : Wiley-Blackwell
Original Publication: Guildford, Surrey : Butterworth Scientific Ltd., c1983-
مواضيع طبية MeSH: RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/metabolism , Neoplasms*/genetics, Humans ; Transcription Factors/genetics ; Apoptosis ; Autophagy
مستخلص: Autophagy, as a highly conserved cellular process, participates in cellular homeostasis by degradation and recycling of damaged organelles and proteins. Besides, autophagy has been evidenced to play a dual role through cancer initiation and progression. In the early stage, it may have a tumor-suppressive function through inducing apoptosis and removing damaged cells and organelles. However, late stages promote tumor progression by maintaining stemness features and induction of chemoresistance. Therefore, identifying and targeting molecular mechanisms involved in autophagy is a potential therapeutic strategy for human cancers. Multiple transcription factors (TFs) are involved in the regulation of autophagy by modulating the expression of autophagy-related genes (ATGs). In addition, a wide array of long noncoding RNAs (lncRNAs), a group of regulatory ncRNAs, have been evidenced to regulate the function of these autophagy-related TFs through tumorigenesis. Subsequently, the lncRNAs/TFs/ATGs axis shows great potential as a therapeutic target for human cancers. Therefore, this review aimed to summarize new findings about the role of lncRNAs in regulating autophagy-related TFs with therapeutic perspectives.
(© 2024 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: RGP.02/557/44 King Khalid University
فهرسة مساهمة: Keywords: autophagy; cancer; lncRNA; transcription factor
المشرفين على المادة: 0 (RNA, Long Noncoding)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20240321 Date Completed: 20240322 Latest Revision: 20240322
رمز التحديث: 20240322
DOI: 10.1002/cbf.3971
PMID: 38509767
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-0844
DOI:10.1002/cbf.3971