دورية أكاديمية
أعرض في EDS

Collagen modifications predictive of lymph node metastasis in dogs with carcinoma in mixed tumours.

التفاصيل البيبلوغرافية
العنوان: Collagen modifications predictive of lymph node metastasis in dogs with carcinoma in mixed tumours.
المؤلفون: Garcia APV; Laboratory of Comparative Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Taborda DYO; Laboratory of Comparative Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Reis LA; Biophotonics Laboratory, Physics Department, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., de Paula AM; Biophotonics Laboratory, Physics Department, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Cassali GD; Laboratory of Comparative Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
المصدر: Frontiers in veterinary science [Front Vet Sci] 2024 Mar 06; Vol. 11, pp. 1362693. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101666658 Publication Model: eCollection Cited Medium: Print ISSN: 2297-1769 (Print) Linking ISSN: 22971769 NLM ISO Abbreviation: Front Vet Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2014]-
مستخلص: Introduction: Mixed tumours in the canine mammary gland are the most common histological type in routine diagnosis. In general, these neoplasms have a favourable prognosis that does not evolve into metastatic disease. However, some cases develop into lymph node metastases and are associated with worse patient survival rates.
Methods: Here is a retrospective study of 46 samples of primary mixed tumours of the canine mammary gland: 15 cases of benign mixed tumours (BMT), 16 cases of carcinoma in mixed tumours without lymph node metastasis (CMT), and 15 cases of carcinomas in mixed tumours with lymph node metastasis (CMTM). In addition, we selected 23 cases of normal mammary glands (NMT) for comparison. The samples were collected from biopsies performed during nodulectomy, simple mastectomy, regional mastectomy, or unilateral/bilateral radical mastectomy. We used multiphoton microscopy, second harmonic generation, and two-photon excited fluorescence, to evaluate the characteristics of collagen fibres and cellular components in biopsies stained with haematoxylin and eosin. We performed Ki67, ER, PR, and HER-2 immunostaining to define the immunophenotype and COX-2. We showed that carcinomas that evolved into metastatic disease (CMTM) present shorter and wavier collagen fibres as compared to CMT.
Results and Discussion: When compared to NMT and BMT the carcinomas present a smaller area of fibre coverage, a larger area of cellular coverage, and a larger number of individual fibres. Furthermore, we observed a correlation between the strong expression of COX-2 and a high rate of cell proliferation in carcinomas with a smaller area covered by cell fibres and a larger number of individual fibres. These findings highlight the fundamental role of collagen during tumour progression, especially in invasion and metastatic dissemination.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Garcia, Taborda, Reis, de Paula and Cassali.)
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فهرسة مساهمة: Keywords: COX-2; breast cancer; canine mammary gland; collagen fibres; extracellular matrix; metastatic disease; mixed canine tumours; tumour microenvironment
تواريخ الأحداث: Date Created: 20240321 Latest Revision: 20240322
رمز التحديث: 20240322
مُعرف محوري في PubMed: PMC10951072
DOI: 10.3389/fvets.2024.1362693
PMID: 38511192
قاعدة البيانات: MEDLINE
الوصف
تدمد:2297-1769
DOI:10.3389/fvets.2024.1362693