دورية أكاديمية
Collagen modifications predictive of lymph node metastasis in dogs with carcinoma in mixed tumours.
العنوان: | Collagen modifications predictive of lymph node metastasis in dogs with carcinoma in mixed tumours. |
---|---|
المؤلفون: | Garcia APV; Laboratory of Comparative Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Taborda DYO; Laboratory of Comparative Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Reis LA; Biophotonics Laboratory, Physics Department, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., de Paula AM; Biophotonics Laboratory, Physics Department, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Cassali GD; Laboratory of Comparative Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. |
المصدر: | Frontiers in veterinary science [Front Vet Sci] 2024 Mar 06; Vol. 11, pp. 1362693. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101666658 Publication Model: eCollection Cited Medium: Print ISSN: 2297-1769 (Print) Linking ISSN: 22971769 NLM ISO Abbreviation: Front Vet Sci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2014]- |
مستخلص: | Introduction: Mixed tumours in the canine mammary gland are the most common histological type in routine diagnosis. In general, these neoplasms have a favourable prognosis that does not evolve into metastatic disease. However, some cases develop into lymph node metastases and are associated with worse patient survival rates. Methods: Here is a retrospective study of 46 samples of primary mixed tumours of the canine mammary gland: 15 cases of benign mixed tumours (BMT), 16 cases of carcinoma in mixed tumours without lymph node metastasis (CMT), and 15 cases of carcinomas in mixed tumours with lymph node metastasis (CMTM). In addition, we selected 23 cases of normal mammary glands (NMT) for comparison. The samples were collected from biopsies performed during nodulectomy, simple mastectomy, regional mastectomy, or unilateral/bilateral radical mastectomy. We used multiphoton microscopy, second harmonic generation, and two-photon excited fluorescence, to evaluate the characteristics of collagen fibres and cellular components in biopsies stained with haematoxylin and eosin. We performed Ki67, ER, PR, and HER-2 immunostaining to define the immunophenotype and COX-2. We showed that carcinomas that evolved into metastatic disease (CMTM) present shorter and wavier collagen fibres as compared to CMT. Results and Discussion: When compared to NMT and BMT the carcinomas present a smaller area of fibre coverage, a larger area of cellular coverage, and a larger number of individual fibres. Furthermore, we observed a correlation between the strong expression of COX-2 and a high rate of cell proliferation in carcinomas with a smaller area covered by cell fibres and a larger number of individual fibres. These findings highlight the fundamental role of collagen during tumour progression, especially in invasion and metastatic dissemination. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Garcia, Taborda, Reis, de Paula and Cassali.) |
References: | Nature. 2013 Sep 19;501(7467):346-54. (PMID: 24048067) Lasers Med Sci. 2018 Dec;33(9):1849-1858. (PMID: 30311083) Res Vet Sci. 2016 Jun;106:121-30. (PMID: 27234549) J Biophotonics. 2020 Oct;13(10):e202000180. (PMID: 32643819) Curr Opin Cell Biol. 2010 Oct;22(5):697-706. (PMID: 20822891) PLoS One. 2019 Oct 25;14(10):e0224504. (PMID: 31652293) Breast Cancer Res. 2017 Jan 19;19(1):9. (PMID: 28103936) Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:4077-80. (PMID: 19964821) Aust Vet J. 2011 Aug;89(8):312-7. (PMID: 24635633) J Biomed Opt. 2008 Sep-Oct;13(5):054050. (PMID: 19021430) Nat Med. 2003 Jun;9(6):796-800. (PMID: 12754503) BMC Cancer. 2015 Nov 24;15:929. (PMID: 26603532) Biomed Opt Express. 2016 Sep 15;7(10):4054-4068. (PMID: 27867715) Vet Anim Sci. 2018 Sep 22;7:100039. (PMID: 32734062) Semin Cancer Biol. 2015 Dec;35:3-10. (PMID: 26416466) Histol Histopathol. 2016 Jun;31(6):675-88. (PMID: 26666308) J Biomed Opt. 2013 Mar;18(3):31106. (PMID: 23172133) Nat Biotechnol. 2003 Nov;21(11):1356-60. (PMID: 14595363) Vet J. 2013 May;196(2):241-6. (PMID: 23031308) Vet Pathol. 2000 May;37(3):239-47. (PMID: 10810988) Phys Med Biol. 2008 Dec 7;53(23):6641-52. (PMID: 18997272) Res Vet Sci. 2017 Dec;115:189-194. (PMID: 28475997) Sci Rep. 2021 Mar 11;11(1):5668. (PMID: 33707516) Biomed Opt Express. 2011 Aug 1;2(8):2307-16. (PMID: 21833367) J Cancer. 2017 Jun 1;8(8):1466-1476. (PMID: 28638462) Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14043-14048. (PMID: 27872289) Elife. 2016 Mar 17;5:. (PMID: 26984280) APMIS. 2015 Jan;123(1):1-8. (PMID: 25131437) J Transl Med. 2019 Sep 14;17(1):309. (PMID: 31521169) Biomaterials. 2020 Feb;230:119647. (PMID: 31791844) Bioengineering (Basel). 2021 Jan 21;8(2):. (PMID: 33494220) J Phys Chem B. 2011 Nov 10;115(44):12759-69. (PMID: 21970315) BMC Vet Res. 2020 Jan 29;16(1):24. (PMID: 31996230) Cold Spring Harb Perspect Biol. 2011 Jan 01;3(1):a004978. (PMID: 21421911) Pharmacol Ther. 2021 May;221:107753. (PMID: 33259885) Vet Pathol. 2011 Jan;48(1):254-65. (PMID: 20876365) J Clin Pathol. 2015 Dec;68(12):1033-5. (PMID: 26209730) Adv Drug Deliv Rev. 2016 Feb 1;97:41-55. (PMID: 26743193) Vet Pathol. 2011 Jan;48(1):117-31. (PMID: 21266722) Am J Pathol. 2011 Mar;178(3):1221-32. (PMID: 21356373) PLoS One. 2017 Jul 6;12(7):e0180448. (PMID: 28683102) Matrix Biol. 2017 Jul;60-61:86-95. (PMID: 27503584) BMC Med. 2008 Apr 28;6:11. (PMID: 18442412) Biomed Opt Express. 2020 Oct 16;11(11):6413-6427. (PMID: 33282498) In Vivo. 2012 May-Jun;26(3):375-9. (PMID: 22523289) Cancer Res. 1982 Jun;42(6):2255-9. (PMID: 7074608) J Cell Sci. 2010 Dec 15;123(Pt 24):4195-200. (PMID: 21123617) Sci Rep. 2019 May 22;9(1):7715. (PMID: 31118443) Tumour Biol. 2018 Apr;40(4):1010428318770953. (PMID: 29663855) |
فهرسة مساهمة: | Keywords: COX-2; breast cancer; canine mammary gland; collagen fibres; extracellular matrix; metastatic disease; mixed canine tumours; tumour microenvironment |
تواريخ الأحداث: | Date Created: 20240321 Latest Revision: 20240322 |
رمز التحديث: | 20240322 |
مُعرف محوري في PubMed: | PMC10951072 |
DOI: | 10.3389/fvets.2024.1362693 |
PMID: | 38511192 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!