دورية أكاديمية
أعرض في EDS

Early-onset neonatal sepsis as a risk factor for peri-intraventricular hemorrhage in premature infants.

التفاصيل البيبلوغرافية
العنوان: Early-onset neonatal sepsis as a risk factor for peri-intraventricular hemorrhage in premature infants.
المؤلفون: Denicol MM; Universidade Federal do Rio Grande do Sul, Postgraduate Program in Epidemiology - Porto Alegre (RS), Brazil., Leotti VB; Universidade Federal do Rio Grande do Sul, Postgraduate Program in Epidemiology - Porto Alegre (RS), Brazil., Soares CRS; Grupo Hospitalar Conceição, Hospital da Criança Conceição - Porto Alegre (RS), Brazil., Hilgert JB; Universidade Federal do Rio Grande do Sul, Postgraduate Program in Epidemiology - Porto Alegre (RS), Brazil.
المصدر: Revista brasileira de epidemiologia = Brazilian journal of epidemiology [Rev Bras Epidemiol] 2024 Mar 18; Vol. 27, pp. e240013. Date of Electronic Publication: 2024 Mar 18 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Associação Brasileira de Pós-Graduação em Saúde Coletiva Country of Publication: Brazil NLM ID: 100954576 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5497 (Electronic) Linking ISSN: 1415790X NLM ISO Abbreviation: Rev Bras Epidemiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: São Paulo, SP, Brasil : Associação Brasileira de Pós-Graduação em Saúde Coletiva, 1998-
مواضيع طبية MeSH: Neonatal Sepsis*/complications , Neonatal Sepsis*/epidemiology , Premature Birth*, Infant, Newborn ; Infant ; Child ; Humans ; Female ; Pregnancy ; Retrospective Studies ; Brazil/epidemiology ; Infant, Premature ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/epidemiology ; Risk Factors
مستخلص: Objective: To assess early-onset sepsis as a risk factor of peri-intraventricular hemorrhage in premature infants born at less than or equal to 34 weeks' gestation and admitted to a neonatal intensive care unit (NICU).
Methods: This retrospective cohort study included premature patients born at less than or equal to 34 weeks' gestation who were admitted to the NICU of a tertiary hospital in southern Brazil, and born from January 2017 to July 2021. Data were collected from patients' medical records. Early-onset sepsis was measured according to the presence or absence of diagnosis within the first 72 hours of life, whereas the outcome, peri-intraventricular hemorrhage, was described as the presence or absence of hemorrhage, regardless of its grade.
Results: Hazard ratios were calculated using Cox regression models. A total of 487 patients were included in the study, of which 169 (34.7%) had some degree of peri-intraventricular hemorrhage. Early-onset sepsis was present in 41.6% of the cases of peri-intraventricular hemorrhage, which revealed a significant association between these variables, with increased risk of the outcome in the presence of sepsis. In the final multivariate model, the hazard ratio for early-onset sepsis was 1.52 (95% confidence interval 1.01-2.27).
Conclusion: Early-onset sepsis and the use of surfactants showed to increase the occurrence of the outcome in premature children born at less than or equal to 34 weeks' gestation. Meanwhile, factors such as antenatal corticosteroids and gestational age closer to 34 weeks' gestations were found to reduce the risk of peri-intraventricular hemorrhage.
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تواريخ الأحداث: Date Created: 20240321 Date Completed: 20240322 Latest Revision: 20240323
رمز التحديث: 20240323
مُعرف محوري في PubMed: PMC10946291
DOI: 10.1590/1980-549720240013
PMID: 38511823
قاعدة البيانات: MEDLINE
الوصف
تدمد:1980-5497
DOI:10.1590/1980-549720240013