دورية أكاديمية
Identification, rapid screening, docking mechanism and in vitro digestion stability of novel DPP-4 inhibitory peptides from wheat gluten with ginger protease.
| العنوان: | Identification, rapid screening, docking mechanism and in vitro digestion stability of novel DPP-4 inhibitory peptides from wheat gluten with ginger protease. |
|---|---|
| المؤلفون: | Pu L; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, P. R. China. xzkong@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, P. R. China., Kong X; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, P. R. China. xzkong@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, P. R. China., Xing R; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, P. R. China. xzkong@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, P. R. China., Wang Y; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, P. R. China. xzkong@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, P. R. China., Zhang C; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, P. R. China. xzkong@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, P. R. China., Hua Y; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, P. R. China. xzkong@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, P. R. China., Chen Y; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, P. R. China. xzkong@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, P. R. China., Li X; State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, P. R. China. xzkong@jiangnan.edu.cn.; School of Food Science and Technology, Jiangnan University, Wuxi, P. R. China. |
| المصدر: | Food & function [Food Funct] 2024 Apr 02; Vol. 15 (7), pp. 3848-3863. Date of Electronic Publication: 2024 Apr 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/drug therapy , Dipeptidyl-Peptidase IV Inhibitors*/chemistry , Plant Proteins* , Cysteine Proteases*, Triticum/chemistry ; Tandem Mass Spectrometry ; Hydrolysis ; Peptides/chemistry ; Glutens ; Digestion ; Dipeptidyl Peptidase 4/chemistry |
| مستخلص: | To better understand the hypoglycemic potential of wheat gluten (WG), we screened dipeptidyl peptidase IV (DPP-4) inhibitory active peptides from WG hydrolysates. WG hydrolysates prepared by ginger protease were found to have the highest DPP-4 inhibitory activity among the five enzymatic hydrolysates, from which a 1-3 kDa fraction was isolated by ultrafiltration. Further characterization of the fraction with nano-HPLC-MS/MS revealed 1133 peptides. Among them, peptides with P' |
| المشرفين على المادة: | EC 3.4.22.67 (zingipain, Zingiber officinale) 0 (Dipeptidyl-Peptidase IV Inhibitors) 0 (Peptides) 8002-80-0 (Glutens) EC 3.4.14.5 (Dipeptidyl Peptidase 4) 0 (Plant Proteins) EC 3.4.- (Cysteine Proteases) |
| تواريخ الأحداث: | Date Created: 20240321 Date Completed: 20240403 Latest Revision: 20240403 |
| رمز التحديث: | 20240403 |
| DOI: | 10.1039/d3fo05423c |
| PMID: | 38512162 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2042-650X |
|---|---|
| DOI: | 10.1039/d3fo05423c |