دورية أكاديمية
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Metabolomic analysis to understand the mechanism of Ti 3 C 2 T x (MXene) toxicity in Daphnia magna.

التفاصيل البيبلوغرافية
العنوان: Metabolomic analysis to understand the mechanism of Ti 3 C 2 T x (MXene) toxicity in Daphnia magna.
المؤلفون: Xiang Q; Yunnan Collaborative Innovation Center for Plateau Lake Ecology and Environmental Health, College of Agronomy and Life Sciences, Kunming University, Kunming 650214, China., Wang Z; Yunnan Collaborative Innovation Center for Plateau Lake Ecology and Environmental Health, College of Agronomy and Life Sciences, Kunming University, Kunming 650214, China., Yan J; Yunnan Collaborative Innovation Center for Plateau Lake Ecology and Environmental Health, College of Agronomy and Life Sciences, Kunming University, Kunming 650214, China., Niu M; Yunnan Collaborative Innovation Center for Plateau Lake Ecology and Environmental Health, College of Agronomy and Life Sciences, Kunming University, Kunming 650214, China., Long W; Yunnan Collaborative Innovation Center for Plateau Lake Ecology and Environmental Health, College of Agronomy and Life Sciences, Kunming University, Kunming 650214, China., Ju Z; School of Ecology and Environmental Sciences, Yunnan University, Kunming 650091, China., Chang X; Yunnan Collaborative Innovation Center for Plateau Lake Ecology and Environmental Health, College of Agronomy and Life Sciences, Kunming University, Kunming 650214, China; Great Lakes Institute for Environmental Research, University of Windsor, Windsor, ON N9B 3P4, Canada. Electronic address: xchang@uwindsor.ca.
المصدر: Aquatic toxicology (Amsterdam, Netherlands) [Aquat Toxicol] 2024 May; Vol. 270, pp. 106904. Date of Electronic Publication: 2024 Mar 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8500246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1514 (Electronic) Linking ISSN: 0166445X NLM ISO Abbreviation: Aquat Toxicol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Netherlands : Elsevier/North Holland Biomedical Press, c1981-
مواضيع طبية MeSH: Daphnia magna* , Water Pollutants, Chemical*/toxicity , Nitrites* , Transition Elements*, Animals ; Daphnia ; Titanium/pharmacology ; Tryptophan/metabolism ; Tryptophan/pharmacology
مستخلص: Due to their potential release into the environment, the ecotoxicity of Ti 3 C 2 T x (MXene) nanomaterials is a growing concern. Unfortunately, little is known about the toxic effects and mechanisms through which Ti 3 C 2 T x induces toxicity in aquatic organisms. The aim of this study is thus to investigate the toxic effects and mechanisms of Daphnia magna upon exposure to Ti 3 C 2 T x with different sheet sizes (100 nm [Ti 3 C 2 T x -100] and 500 nm [Ti 3 C 2 T x -500]) by employing conventional toxicology and metabolomics analysis. The results showed that exposure to both Ti 3 C 2 T x -100 and Ti 3 C 2 T x -500 at 10 μg/mL resulted in a significant accumulation of Ti 3 C 2 T x in D. magna, but no effects on the mortality or growth of D. magna were observed. However, the metabolomics results revealed that Ti 3 C 2 T x -100 and Ti 3 C 2 T x -500 induced significant changes in up to 265 and 191 differential metabolites in D. magna, respectively, of which 116 metabolites were common for both. Ti 3 C 2 T x -100-induced metabolites were mainly enriched in phospholipid, pyrimidine, tryptophan, and arginine metabolism, whereas Ti 3 C 2 T x -500-induced metabolites were mainly enriched in the glycerol-ester, tryptophan, and glyoxylate metabolism and the pentose phosphate pathway. These results indicated that the toxicity of Ti 3 C 2 T x to D. magna has a size-dependent effect at the metabolic level, and both sheet sizes of Ti 3 C 2 T x can lead to metabolic disturbances in D. magna by interfering with lipid and amino acid metabolism pathways.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Ecotoxicity; Lipid metabolism; MXenes; Metabolite changes; Water fleas
المشرفين على المادة: D1JT611TNE (Titanium)
8DUH1N11BX (Tryptophan)
0 (MXene)
0 (Water Pollutants, Chemical)
0 (Nitrites)
0 (Transition Elements)
تواريخ الأحداث: Date Created: 20240321 Date Completed: 20240415 Latest Revision: 20240415
رمز التحديث: 20240415
DOI: 10.1016/j.aquatox.2024.106904
PMID: 38513426
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1514
DOI:10.1016/j.aquatox.2024.106904