دورية أكاديمية
Peptide-derived ligands for the discovery of safer opioid analgesics.
| العنوان: | Peptide-derived ligands for the discovery of safer opioid analgesics. |
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| المؤلفون: | Eliasof A; College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA., Liu-Chen LY; Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA., Li Y; College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA. Electronic address: liyangme@cop.sc.edu. |
| المصدر: | Drug discovery today [Drug Discov Today] 2024 May; Vol. 29 (5), pp. 103950. Date of Electronic Publication: 2024 Mar 20. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kidlington, Oxford : Irvington, NJ : Elsevier Science Ltd. ; Distributed by Virgin Mailing and Distribution, c1996- |
| مواضيع طبية MeSH: | Analgesics, Opioid*/adverse effects , Analgesics, Opioid*/pharmacology , Opioid Peptides* , Drug Discovery*/methods, Animals ; Humans ; Ligands ; Pain/drug therapy ; Receptors, Opioid, mu/metabolism ; Peptides/pharmacology ; Peptides/therapeutic use |
| مستخلص: | Drugs targeting the μ-opioid receptor (MOR) remain the most efficacious analgesics for the treatment of pain, but activation of MOR with current opioid analgesics also produces harmful side effects, notably physical dependence, addiction, and respiratory depression. Opioid peptides have been accepted as promising candidates for the development of safer and more efficacious analgesics. To develop peptide-based opioid analgesics, strategies such as modification of endogenous opioid peptides, development of multifunctional opioid peptides, G protein-biased opioid peptides, and peripherally restricted opioid peptides have been reported. This review seeks to provide an overview of the opioid peptides that produce potent antinociception with much reduced side effects in animal models and highlight the potential advantages of peptides as safer opioid analgesics. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
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| معلومات مُعتمدة: | P30 DA013429 United States DA NIDA NIH HHS; R01 DA041359 United States DA NIDA NIH HHS; R01 DA056581 United States DA NIDA NIH HHS |
| المشرفين على المادة: | 0 (Analgesics, Opioid) 0 (Ligands) 0 (Opioid Peptides) 0 (Receptors, Opioid, mu) 0 (Peptides) |
| تواريخ الأحداث: | Date Created: 20240321 Date Completed: 20240502 Latest Revision: 20240625 |
| رمز التحديث: | 20240625 |
| مُعرف محوري في PubMed: | PMC11127667 |
| DOI: | 10.1016/j.drudis.2024.103950 |
| PMID: | 38514040 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-5832 |
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| DOI: | 10.1016/j.drudis.2024.103950 |