دورية أكاديمية
UPLC-Q-TOF/MS analysis of chemical components of single decoction and combined decoction of Qige decoction reveals the differences between various preparation processes.
| العنوان: | UPLC-Q-TOF/MS analysis of chemical components of single decoction and combined decoction of Qige decoction reveals the differences between various preparation processes. |
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| المؤلفون: | Guo KX; Guangzhou University of Chinese Medicine, Guangzhou, China., Yu XQ; Guangzhou University of Chinese Medicine, Guangzhou, China., Tang H; Guangzhou University of Chinese Medicine, Guangzhou, China., Wei HY; Guangzhou University of Chinese Medicine, Guangzhou, China., Li YF; Guangzhou University of Chinese Medicine, Guangzhou, China., Fan SM; Guangzhou University of Chinese Medicine, Guangzhou, China., Huang KE; Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangzhou, China., Ke XH; Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangzhou, China. |
| المصدر: | Biomedical chromatography : BMC [Biomed Chromatogr] 2024 Jun; Vol. 38 (6), pp. e5865. Date of Electronic Publication: 2024 Mar 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1990- : Chichester : Wiley Original Publication: London : Heyden & Son, c1986-1990 |
| مواضيع طبية MeSH: | Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/analysis , Mass Spectrometry*/methods, Chromatography, High Pressure Liquid/methods ; Principal Component Analysis ; Flavonoids/analysis ; Flavonoids/chemistry |
| مستخلص: | The aim of this work was to explore the differences between various pharmaceutical processes in combined solutions of a single decoction (QGHBY) and a combined decoction (QGHJY) of Qi-Ge decoction from the perspective of chemical composition changes, so as to further guide the clinical application of drugs. A combined solution of a single decoction and a combined decoction of Astragali Radix, Puerariae Lobatae Radix and Citri Reticulatae Chachiensis Pericarpium was prepared with the same technological parameters. The chemical components of the two were detected and identified based on UPLC-Q-TOF/MS, and the different components were determined by principal component analysis. Eighty-eight compounds were identified in the pharmaceutical solution of Qi-Ge decoction. Principal component analysis revealed 11 different components of QGHBY and QGHJY with the conditions of Variable Importance in Projection (VIP) ≥ 1, fold change ≥ 2 and p < 0.05, among which hesperidin, hesperitin, isosinensetin, sinensetin and 5-demethylnobiletin were the components of Citri Reticulatae Chachiensis Pericarpium. The levels of these 11 different components in QGHJY were higher than those of QGHBY. The combined decoction is beneficial for the dissolution of flavonoids and other chemical components, and there is a significant difference in the content of chemical components between modern herbal concentrate granules and traditional decoctions. (© 2024 John Wiley & Sons Ltd.) |
| References: | Peng, C., Zhou, Z. M., Li, J., Luo, Y., Zhou, Y. S., Ke, X. H., & Huang, K. E. (2019). CCl4‐induced liver injury was ameliorated by qi‐Ge decoction through the antioxidant pathway[J]. Evidence‐Based Complementary and Alternative Medicine, 2019, 5941263. Wang, X., Hasegawa, J., Kitamura, Y., Wang, Z., Matsuda, A., Shinoda, W., Miura, N., & Kimura, K. (2011). Effects of hesperidin on the progression of hypercholesterolemia and fatty liver induced by high‐cholesterol diet in rats. Journal of Pharmacological Sciences, 117, 129–138. https://doi.org/10.1254/jphs.11097fp Epub 2011 Oct 7. PMID: 21979313. Wu, D., Liu, F. J., & Liao, C. Z. (2003). Effect of Chinese medicine on chemical composition[J]. Chinese Patent Medicine, 2, 67–69. Yen, J. H., Weng, C. Y., & Li, S. M. (2011). Citrus flavonoid 5‐demethylnobiletin suppresses scavenger receptor expression in THP‐1 cells and alters lipid homeostasis in HepG2 liver cells[J]. Molecular Nutrition & Food Research, 55, 733–748. https://doi.org/10.1002/mnfr.201000226. Zhang, W., Sun, Y. F., & Jin, C. S. (2022). Research status and prospect of traditional Chinese medicine formula granules[J]. Chinese Traditional and Herbal Drugs, 22, 7221–7233. |
| معلومات مُعتمدة: | 2021xk33 Guangzhou University of Chinese Medicine; 82074099 National Natural Science Foundation of China; 2023A151501112 Guangdong Basic and Applied Basic Research Foundation |
| فهرسة مساهمة: | Keywords: Qi‐Ge decoction (QG); UPLC–Q‐TOF/MS; combined decoction; combined solution of a single decoction; principal component analysis (PCA) |
| تواريخ الأحداث: | Date Created: 20240321 Date Completed: 20240519 Latest Revision: 20240519 |
| رمز التحديث: | 20240520 |
| DOI: | 10.1002/bmc.5865 |
| PMID: | 38514246 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1099-0801 |
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| DOI: | 10.1002/bmc.5865 |