دورية أكاديمية
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VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection.

التفاصيل البيبلوغرافية
العنوان: VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection.
المؤلفون: Tyagi S; Mycobacterial Pathogenesis Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India.; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India., Sadhu S; Immunobiology Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India., Sharma T; Mycobacterial Pathogenesis Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India.; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India., Paul A; Complex Analysis Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India., Pandey M; Mycobacterial Pathogenesis Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India., Nain VK; Mycobacterial Pathogenesis Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India.; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India., Rathore DK; Immunobiology Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India., Chatterjee S; Complex Analysis Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India., Awasthi A; Immunobiology Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India., Pandey AK; Mycobacterial Pathogenesis Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India.
المصدر: Frontiers in immunology [Front Immunol] 2024 Mar 07; Vol. 15, pp. 1302163. Date of Electronic Publication: 2024 Mar 07 (Print Publication: 2024).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/pathogenicity , Tuberculosis*/immunology , Tuberculosis*/metabolism , Ribonucleases*/genetics , Ribonucleases*/metabolism, Animals ; Mice ; Immunity, Innate ; Phenotype ; Toxins, Biological
مستخلص: Mechanistic understanding of antibiotic persistence is a prerequisite in controlling the emergence of MDR cases in Tuberculosis (TB). We have reported that the cholesterol-induced activation of VapC12 ribonuclease is critical for disease persistence in TB. In this study, we observed that relative to the wild type, mice infected with Δ vapC12 induced a pro-inflammatory response, had a higher pathogen load, and responded better to the anti-TB treatment. In a high-dose infection model, all the mice infected with Δ vapC12 succumbed early to the disease. Finally, we reported that the above phenotype of Δ vapC12 was dependent on the presence of the TLR4 receptor. Overall, the data suggests that failure of a timely resolution of the early inflammation by the Δ vapC12 infected mice led to hyperinflammation, altered T-cell response and high bacterial load. In conclusion, our findings suggest the role of the VapC12 toxin in modulating the innate immune response of the host in ways that favor the long-term survival of the pathogen inside the host.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
(Copyright © 2024 Tyagi, Sadhu, Sharma, Paul, Pandey, Nain, Rathore, Chatterjee, Awasthi and Pandey.)
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فهرسة مساهمة: Keywords: and inflammation; neutrophils; persistence; toxin-antitoxin; tuberculosis; virulence
المشرفين على المادة: 0 (Toxins, Biological)
EC 3.1.- (Ribonucleases)
تواريخ الأحداث: Date Created: 20240322 Date Completed: 20240325 Latest Revision: 20240715
رمز التحديث: 20240715
مُعرف محوري في PubMed: PMC10955575
DOI: 10.3389/fimmu.2024.1302163
PMID: 38515752
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2024.1302163