دورية أكاديمية
أعرض في EDS

Responsive Anionophores with AND Logic Multi-Stimuli Activation.

التفاصيل البيبلوغرافية
العنوان: Responsive Anionophores with AND Logic Multi-Stimuli Activation.
المؤلفون: Ahmad M; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Johnson TG; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Flerin M; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Duarte F; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Langton MJ; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 May 27; Vol. 63 (22), pp. e202403314. Date of Electronic Publication: 2024 Apr 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE
أسماء مطبوعة: Publication: <2004-> : Weinheim : Wiley-VCH
Original Publication: Weinheim/Bergstr. : New York, : Verlag Chemie ; Academic Press, c1962-
مواضيع طبية MeSH: Hydrogen Bonding*, Anions/chemistry ; Ionophores/chemistry ; Oxidation-Reduction ; Molecular Structure ; Ion Transport
مستخلص: Artificial ion transport systems have emerged as an important class of compounds that promise applications in chemotherapeutics as anticancer agents or to treat channelopathies. Stimulus-responsive systems that offer spatiotemporally controlled activity for targeted applications remain rare. Here we utilize dynamic hydrogen bonding interactions of a 4,6-dihydroxy-isophthalamide core to generate a modular platform enabling access to stimuli-responsive ion transporters that can be activated in response to a wide variety of external stimuli, including light, redox, and enzymes, with excellent OFF-ON activation profiles. Alkylation of the two free hydroxyl groups with stimulus-responsive moieties locks the amide bonds through intramolecular hydrogen bonding and hence makes them unavailable for anion binding and transport. Triggering using a particular stimulus to cleave both cages reverses the hydrogen bonding arrangement, to generate a highly preorganized anion binding cavity for efficient transmembrane transport. Integration of two cages that are responsive to orthogonal stimuli enables multi-stimuli activation, where both stimuli are required to trigger transport in an AND logic process. Importantly, the strategy provides a facile method to post-functionalize the highly active transporter core with a variety of stimulus-responsive moieties for targeted activation with multiple triggers.
(© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
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معلومات مُعتمدة: RPG-2020-130 Leverhulme Trust; Royal Society
فهرسة مساهمة: Keywords: anion transport; anions; hydrogen bonding; membranes; stimuli-responsive
تواريخ الأحداث: Date Created: 20240322 Date Completed: 20240517 Latest Revision: 20240517
رمز التحديث: 20240517
DOI: 10.1002/anie.202403314
PMID: 38517056
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-3773
DOI:10.1002/anie.202403314