دورية أكاديمية
Treatment of Refractory Vulvar Lichen Sclerosus With Methotrexate.
| العنوان: | Treatment of Refractory Vulvar Lichen Sclerosus With Methotrexate. |
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| المؤلفون: | Ghafari-Saravi A; Department of Dermatology, Oregon Health and Science University, Portland, OR., Foster E |
| المصدر: | Journal of lower genital tract disease [J Low Genit Tract Dis] 2024 Apr 01; Vol. 28 (2), pp. 202-204. Date of Electronic Publication: 2024 Jan 10. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9704963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-0976 (Electronic) Linking ISSN: 10892591 NLM ISO Abbreviation: J Low Genit Tract Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Malden, MA : Blackwell Science Inc., c1997- |
| مواضيع طبية MeSH: | Lichen Sclerosus et Atrophicus*/drug therapy , Vulvar Lichen Sclerosus*/drug therapy, Adult ; Female ; Humans ; Administration, Topical ; Glucocorticoids/therapeutic use ; Methotrexate/therapeutic use |
| مستخلص: | We report the successful treatment of severe vulvar lichen sclerosus refractory to topical corticosteroids in 3 adult female patients using low-dose oral methotrexate. All cases reported symptomatic and clinical improvement within 12 weeks. Competing Interests: The authors have declared they have no conflicts of interest. (Copyright © 2024, ASCCP.) |
| References: | Akel R, Fuller C. Updates in lichen sclerosis: British Association of Dermatologists guidelines for the management of lichen sclerosus 2018. Br J Dermatol . 2018;178:823. Wehbe-Alamah H, Kornblau BL, Haderer J, et al. Silent no more! The lived experiences of women with lichen sclerosis. J Am Acad Nurse Pract 2012;24:499–505. Tran DA, Tan X, Macri CJ, et al. Lichen sclerosus: an autoimmunopathogenic and genomic enigma with emerging genetic and immune targets. Int J Biol Sci 2019;15:1429–39. Roenigk HH, Auerbach R, Maibach H, et al. Methotrexate in psoriasis: consensus conference. J Am Acad Dermatol 1998;38:478–85. Kroft E, Creemers M, Van Den Hoogen F, et al. Effectiveness, side-effects and period of remission after treatment with methotrexate in localized scleroderma and related sclerotic skin diseases: an inception cohort study. Br J Dermatol . 2009;160:1075–82. Weatherhead S, Wahie S, Reynolds N, et al. An open-label, dose-ranging study of methotrexate for moderate-to-severe adult atopic eczema. Br J Dermatol 2007;156:346–51. Lundqvist EN, Wahlin YB, Hofer P-A. Methotrexate supplemented with steroid ointments for the treatment of severe erosive lichen ruber. Acta Derm Venereol 2002;82:63–4. Jang N, Fischer G. Treatment of erosive vulvovaginal lichen planus with methotrexate. Australas J Dermatol 2008;49:216. Kreuter A, Tigges C, Gaifullina R, et al. Pulsed high-dose corticosteroids combined with low-dose methotrexate treatment in patients with refractory generalized extragenital lichen sclerosus. Arch Dermatol 2009;145:1303–8. Cuellar-Barboza A, Bashyam AM, Ghamrawi RI, et al. Methotrexate for the treatment of recalcitrant genital and extragenital lichen sclerosus: a retrospective series. Dermatol Ther 2020;33:e13473. Maździarz A, Osuch B, Kowalska M, et al. Photodynamic therapy in the treatment of vulvar lichen sclerosus. Photodiagnosis Photodyn Ther 2017;19:135–9. Warren R, Weatherhead S, Smith C, et al. British Association of Dermatologists' guidelines for the safe and effective prescribing of methotrexate for skin disease 2016. Br J Dermatol . 2016;175:23–44. |
| المشرفين على المادة: | 0 (Glucocorticoids) YL5FZ2Y5U1 (Methotrexate) |
| تواريخ الأحداث: | Date Created: 20240322 Date Completed: 20240325 Latest Revision: 20240408 |
| رمز التحديث: | 20240409 |
| DOI: | 10.1097/LGT.0000000000000795 |
| PMID: | 38518219 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1526-0976 |
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| DOI: | 10.1097/LGT.0000000000000795 |