دورية أكاديمية
Melanoma on congenital melanocytic nevi.
| العنوان: | Melanoma on congenital melanocytic nevi. |
|---|---|
| المؤلفون: | Alos L; Department of Pathology, Hospital Clinic de Barcelona, Barcelona, Spain; University of Barcelona, Barcelona, Spain; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; EORTC (European Organisation for Research and Treatment of Cancer) Melanoma Group., Carrasco A; Department of Pathology, Hospital Clinic de Barcelona, Barcelona, Spain., Teixidó C; Department of Pathology, Hospital Clinic de Barcelona, Barcelona, Spain; University of Barcelona, Barcelona, Spain; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Molecular Biology Core, Hospital Clinic de Barcelona, Barcelona, Spain., Szumera-Ciećkiewicz A; EORTC (European Organisation for Research and Treatment of Cancer) Melanoma Group; Maria Sklodowska-Curie National Research Institute of Oncology, Department of Pathology, Warsaw, Poland., Vicente A; Pediatric Dermatology Department, Hospital Sant Joan de Déu, Esplugues del Llobregat, Barcelona, Spain., Massi D; EORTC (European Organisation for Research and Treatment of Cancer) Melanoma Group; Pathology Unit, Department of Health Sciences, University of Florence, Florence, Italy., Carrera C; University of Barcelona, Barcelona, Spain; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Department of Dermatology, Hospital Clínic de Barcelona and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Spain. Electronic address: ccarrera@clinic.cat. |
| المصدر: | Pathology, research and practice [Pathol Res Pract] 2024 Apr; Vol. 256, pp. 155262. Date of Electronic Publication: 2024 Mar 11. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Gustav Fischer Verlag Original Publication: Stuttgart, New York, Fischer. |
| مواضيع طبية MeSH: | Melanoma*/genetics , Melanoma*/pathology , Skin Neoplasms*/genetics , Skin Neoplasms*/pathology , Nevus, Pigmented*/genetics , Nevus, Epithelioid and Spindle Cell* , Nitroimidazoles*, Adult ; Infant, Newborn ; Adolescent ; Humans ; Child, Preschool |
| مستخلص: | Among nevus-associated melanomas, which overall account for 20%-30% of all melanomas, those arising specifically in congenital melanocytic nevi are infrequent, but can be disproportionately frequent in childhood and adolescence. Congenital melanocytic nevi (CMNi) are common benign melanocytic tumors that are present at birth or become apparent in early childhood. They are classified based on the projected adult size. Small and medium-sized CMNi are frequent, whereas large/giant CMNi (over 20 cm in diameter) are rare, but can be associated with high morbidity due to marked aesthetic impairment and the risk of neurocutaneous syndrome or melanoma development. In this setting, melanomas can appear in early childhood and are very aggressive, while the risk of small-medium CMNi of developing melanoma is low and similar to non-congenital melanocytic nevi. Histologically, most melanomas on CMNi initiate their growth at the epidermal-dermal junction, but in large/giant CMNi they can develop entirely in the dermis, in deeper tissues, or in extracutaneous sites (especially in the central nervous system). Most CMNi harbour an NRAS mutation, but other genes are rarely involved, and gene translocations have recently been described. However, no prognostic implications have been associated with the CMN genotype. Melanomas developed on CMNi harbour additional molecular alterations to which the aggressive clinical course of these tumors has been attributed. This review covers the distinctive clinical and pathological aspects of melanomas on CMNi, and includes the epidemiology, etiopathogenesis, clinical and dermoscopic presentation, histological and molecular characteristics, as well as tumour behaviour. Competing Interests: Declaration of Competing Interest The authors have no conflict of interest to declare. (Copyright © 2024 Elsevier GmbH. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Congenital melanocytic nevus; Melanoma; NRAS; Neurocutaneous syndrome; Proliferative nodule |
| المشرفين على المادة: | P917JW98BD (1-methyl-5-chloro-4-nitroimidazole) 0 (Nitroimidazoles) |
| SCR Disease Name: | Melanocytic nevus syndrome, congenital |
| تواريخ الأحداث: | Date Created: 20240322 Date Completed: 20240415 Latest Revision: 20240415 |
| رمز التحديث: | 20240415 |
| DOI: | 10.1016/j.prp.2024.155262 |
| PMID: | 38518732 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1618-0631 |
|---|---|
| DOI: | 10.1016/j.prp.2024.155262 |