دورية أكاديمية
أعرض في EDS

Metformin and other anti-diabetic medication use and breast cancer incidence in the Nurses' Health Studies.

التفاصيل البيبلوغرافية
العنوان: Metformin and other anti-diabetic medication use and breast cancer incidence in the Nurses' Health Studies.
المؤلفون: Wang T; Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.; Division of Medical Oncology, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.; Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA., Chai B; Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA., Chen WY; Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Holmes MD; Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA., Erdrich J; Department of Surgery, The University of Arizona, Tucson, Arizona, USA., Hu FB; Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA., Rosner BA; Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA., Tamimi RM; Department of Population Health Sciences, Weill Cornell Medicine, New York, New York, USA., Willett WC; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA., Kang JH; Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA., Eliassen AH; Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
المصدر: International journal of cancer [Int J Cancer] 2024 Jul 15; Vol. 155 (2), pp. 211-225. Date of Electronic Publication: 2024 Mar 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: 1995- : New York, NY : Wiley-Liss
Original Publication: 1966-1984 : Genève : International Union Against Cancer
مواضيع طبية MeSH: Metformin*/therapeutic use , Breast Neoplasms*/epidemiology , Breast Neoplasms*/drug therapy , Hypoglycemic Agents*/therapeutic use , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/epidemiology, Humans ; Female ; Incidence ; Middle Aged ; Adult ; Prospective Studies ; United States/epidemiology ; Risk Factors ; Nurses/statistics & numerical data ; Proportional Hazards Models
مستخلص: We aimed to examine the association between the use of metformin and other anti-diabetic medications and breast cancer incidence within two large prospective cohort studies. We followed 185,181 women who participated in the Nurses' Health Study (NHS; 1994-2016) and the NHSII (1995-2017), with baseline corresponding to the date metformin was approved for type 2 diabetes (T2D) treatment in the US Information on T2D diagnosis, anti-diabetes medications, and other covariates was self-reported at baseline and repeatedly assessed by follow-up questionnaires every 2 years. Breast cancer cases were self-reported and confirmed by medical record review. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between medication use and breast cancer were estimated using Cox proportional hazards regression models, adjusting for breast cancer risk factors. During 3,324,881 person-years of follow-up, we ascertained 9,192 incident invasive breast cancer cases, of which 451 were among women with T2D. Compared with women without T2D (n = 169,263), neither metformin use (HR = 0.97; 95% CI = 0.81-1.15) nor other anti-diabetic medications use (HR = 1.11; 95% CI = 0.90-1.36) associated with significantly lower breast cancer incidence. Among women with T2D (n = 15,918), compared with metformin never users, metformin ever use was not significantly inversely associated with breast cancer (HR = 0.92; 95% CI = 0.74-1.15). Although we observed that past use of metformin was inversely associated with breast cancer in the T2D population (HR = 0.67; 95% CI = 0.48-0.94), current use (HR = 1.01; 95% CI = 0.80-1.27) and longer duration of metformin use were not associated with breast cancer (each 2-year interval: HR = 1.01; 95% CI = 0.95-1.07). Overall, metformin use was not associated with the risk of developing breast cancer among the overall cohort population or among women with T2D.
(© 2024 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)
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معلومات مُعتمدة: R01 CA050385 United States CA NCI NIH HHS; R01 ES028033 United States ES NIEHS NIH HHS; P01 CA087969 United States CA NCI NIH HHS; R00 CA267557 United States CA NCI NIH HHS; UM1 CA186107 United States CA NCI NIH HHS; T32 CA009001 United States CA NCI NIH HHS; UM1CA186107 United States CA NCI NIH HHS; U01CA176726 United States CA NCI NIH HHS; P01CA87969 United States CA NCI NIH HHS; K99 CA267557 United States CA NCI NIH HHS; R01CA050385 United States CA NCI NIH HHS; R01ES028033 United States ES NIEHS NIH HHS; R00CA267557 United States CA NCI NIH HHS; K99CA267557 United States CA NCI NIH HHS; U01 CA176726 United States CA NCI NIH HHS; Breast Cancer Research Foundation; T32CA009001 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: breast cancer; diabetes mellitus; metformin
تواريخ الأحداث: Date Created: 20240323 Date Completed: 20240515 Latest Revision: 20240517
رمز التحديث: 20240517
مُعرف محوري في PubMed: PMC11096056
DOI: 10.1002/ijc.34917
PMID: 38520039
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0215
DOI:10.1002/ijc.34917