دورية أكاديمية
أعرض في EDS

Exosomal circSTRBP from cancer cells facilitates gastric cancer progression via regulating miR-1294/miR-593-3p/E2F2 axis.

التفاصيل البيبلوغرافية
العنوان: Exosomal circSTRBP from cancer cells facilitates gastric cancer progression via regulating miR-1294/miR-593-3p/E2F2 axis.
المؤلفون: Wang Y; Department of Gastroenterology, Bozhou Hospital affiliated to Anhui Medical University, Bozhou, China., Zou R; Department of Gastroenterology, Wuhan Puren Hospital, Wuhan University of Science and Technology, Wuhan, China., Li D; Department of Anesthesiology, The Fifth Hospital of Wuhan, China., Gao X; Department of Gastroenterology, Bozhou Hospital affiliated to Anhui Medical University, Bozhou, China., Lu X; Department of Gastroenterology, Bozhou Hospital affiliated to Anhui Medical University, Bozhou, China.
المصدر: Journal of cellular and molecular medicine [J Cell Mol Med] 2024 Apr; Vol. 28 (8), pp. e18217.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, England : Wiley-Blackwell
Original Publication: Bucharest : "Carol Davila" University Press, 2000-
مواضيع طبية MeSH: Stomach Neoplasms*/genetics , MicroRNAs*/genetics, Humans ; Animals ; Cell Transformation, Neoplastic ; Biological Assay ; Cell Proliferation/genetics ; Disease Models, Animal ; Cell Line, Tumor ; E2F2 Transcription Factor
مستخلص: CircRNAs represent a new class of non-coding RNAs which show aberrant expression in diverse cancers, such as gastric cancer (GC). circSTRBP, for instance, is suggested to be overexpressed in GC cells and tissues. However, the biological role of circSTRBP in the progression of GC and the potential mechanisms have not been investigated. circSTRBP levels within GC cells and tissues were measured by RT-qPCR. The stability of circSTRBP was assessed by actinomycin D and Ribonuclease R treatment. Cell proliferation, migration, invasion and in vitro angiogenic abilities after circSTRBP knockdown were analysed through CCK-8 assay, transwell culture system and the tube formation assay. The interaction of circSTRBP with the predicted target microRNA (miRNA) was examined by RNA immunoprecipitation and luciferase reporter assays. Xenograft tumour model was established to evaluate the role of exosomal circSTRBP in the tumour formation of GC cells. circSTRBP was upregulated in GC cells and tissues, and there was an increased level of circSTRBP in GC-derived exosomes. circSTRBP in the exosomes enhanced GC cell growth and migration in vitro, which modulates E2F Transcription Factor 2 (E2F2) expression through targeting miR-1294 and miR-593-3p. Additionally, exosomal circSTRBP promoted the tumour growth of GC cells in the xenograft model. Exosomal circSTRBP is implicated in the progression of GC by modulating the activity of miR-1294/miR-593-3p/E2F2 axis.
(© 2024 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: bzzc2021023 2021 Bozhou City major research and development project
فهرسة مساهمة: Keywords: E2F2 by modulating; circRNA; circSTRBP; exosome; gastric cancer; miRNA
المشرفين على المادة: 0 (MicroRNAs)
0 (E2F2 protein, human)
0 (E2F2 Transcription Factor)
0 (MIRN1294 microRNA, human)
0 (MIRN593 microRNA, human)
تواريخ الأحداث: Date Created: 20240323 Date Completed: 20240325 Latest Revision: 20240325
رمز التحديث: 20240325
مُعرف محوري في PubMed: PMC10960172
DOI: 10.1111/jcmm.18217
PMID: 38520208
قاعدة البيانات: MEDLINE
الوصف
تدمد:1582-4934
DOI:10.1111/jcmm.18217