دورية أكاديمية
أعرض في EDS

Identification of differentially expressed autophagy-related genes in cases of intracranial aneurysm: Bioinformatics analysis.

التفاصيل البيبلوغرافية
العنوان: Identification of differentially expressed autophagy-related genes in cases of intracranial aneurysm: Bioinformatics analysis.
المؤلفون: Zhou H; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shinan District, Qingdao, Shandong 266000, China., Song Y; Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510000, China; Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, Shandong 266000, China., Wang C; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shinan District, Qingdao, Shandong 266000, China., Zhu Q; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shinan District, Qingdao, Shandong 266000, China., Feng Y; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Shinan District, Qingdao, Shandong 266000, China. Electronic address: fengyugong@126.com.
المصدر: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2024 Jun; Vol. 33 (6), pp. 107687. Date of Electronic Publication: 2024 Mar 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Saunders Country of Publication: United States NLM ID: 9111633 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8511 (Electronic) Linking ISSN: 10523057 NLM ISO Abbreviation: J Stroke Cerebrovasc Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia, PA : Saunders
Original Publication: New York, NY : Demos Publications, [1991-
مواضيع طبية MeSH: Intracranial Aneurysm*/genetics , Computational Biology* , Protein Interaction Maps*/genetics , Autophagy*/genetics , Gene Regulatory Networks* , Gene Expression Profiling* , Databases, Genetic* , Proto-Oncogene Mas*, Humans ; Transcriptome ; Autophagy-Related Proteins/genetics ; Genetic Predisposition to Disease ; Predictive Value of Tests ; Gene Expression Regulation ; Signal Transduction/genetics
مستخلص: Objective: Recent research indicates that autophagy is essential for the rupture of intracranial aneurysm (IA). This study aimed to examine and validate potential autophagy-related genes (ARGs) in cases of IA using bioinformatics analysis.
Methods: Two expression profiles (GSE54083 and GSE75436) were obtained from the Gene Expression Omnibus database. Differentially expressed ARGs (DEARGs) in cases of IA were screened using GSE75436, and enrichment analysis and Protein-Protein Interaction (PPI) networks were used to identify the hub genes and related pathways. Furthermore, a novel predictive diagnostic signature for IA based on the hub genes was constructed. The area under the Receiver Operating Characteristic curve (AUC) was used to evaluate the signature performance in GSE75436.
Results: In total, 75 co-expressed DEARGs were identified in the GSE75436 and GSE54083 dataset (28 upregulated and 47 downregulated genes). Enrichment analysis of DEARGs revealed several enriched terms associated with proteoglycans in cancer and human immunodeficiency virus 1 infection. PPI analysis revealed interactions between these genes. Hub DEARGs included insulin-like growth factor 1, clusters of differentiation 4, cysteine-aspartic acid protease 8, Bcl-2-like protein 11, mouse double mutant 2 homolog, toll-like receptor 4, growth factor receptor-bound protein 2, Jun proto-oncogene, AP-1 transcription factor subunit, hypoxia inducible factor 1 alpha, and erythroblastic oncogene B-2. Notably, the signature showed good performance in distinguishing IA (AUC = 0.87). The sig calibration curves showed good calibration.
Conclusion: Bioinformatic analysis identified 75 potential DEARGs in cases of IA. This study revealed that IA is affected by autophagy, which could explain the pathogenesis of IA and aid in its diagnosis and treatment. However, future research with experimental validation is necessary to identify potential DEARGs in cases of IA.
Competing Interests: Declaration of competing interest None of the authors has any conflict of interest
(Copyright © 2024 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Autophagy; Autophagy-related genes; Bioinformatics analysis; Biomarkers; Intracranial aneurysm
المشرفين على المادة: 0 (Proto-Oncogene Mas)
0 (MAS1 protein, human)
0 (Autophagy-Related Proteins)
تواريخ الأحداث: Date Created: 20240323 Date Completed: 20240510 Latest Revision: 20240510
رمز التحديث: 20240511
DOI: 10.1016/j.jstrokecerebrovasdis.2024.107687
PMID: 38521147
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2024.107687