دورية أكاديمية
Qualitative and quantitative changes in mitochondrial DNA associated with cervical cancer: A comprehensive review.
العنوان: | Qualitative and quantitative changes in mitochondrial DNA associated with cervical cancer: A comprehensive review. |
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المؤلفون: | Pereira IOA; School of Pharmacy, UFOP - Federal University of Ouro Preto, Ouro Preto, MG, Brazil., Silva NNT; School of Pharmacy, UFOP - Federal University of Ouro Preto, Ouro Preto, MG, Brazil., Lima AA; School of Pharmacy, UFOP - Federal University of Ouro Preto, Ouro Preto, MG, Brazil., da Silva GN; School of Pharmacy, UFOP - Federal University of Ouro Preto, Ouro Preto, MG, Brazil. |
المصدر: | Environmental and molecular mutagenesis [Environ Mol Mutagen] 2024 Mar-Apr; Vol. 65 (3-4), pp. 143-152. Date of Electronic Publication: 2024 Mar 24. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2280 (Electronic) Linking ISSN: 08936692 NLM ISO Abbreviation: Environ Mol Mutagen Subsets: MEDLINE |
أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York, NY : Liss, c1987- |
مواضيع طبية MeSH: | Uterine Cervical Neoplasms*/genetics , Uterine Cervical Neoplasms*/virology , Uterine Cervical Neoplasms*/pathology , DNA, Mitochondrial*/genetics , DNA Copy Number Variations* , Papillomavirus Infections*/complications , Papillomavirus Infections*/genetics , Papillomavirus Infections*/virology, Humans ; Female ; Mitochondria/genetics ; Mitochondria/metabolism ; Biomarkers, Tumor/genetics ; Prognosis |
مستخلص: | Cervical cancer is the fourth most commonly diagnosed cancer in women and is considered a preventable disease, as vaccination and screening programs effectively reduce its incidence and mortality rates. Disease physiopathology and malignant cell transformation is a complex process, but it is widely known that high-risk HPV (hrHPV) infection is a necessary risk factor for cancer development. Mitochondria, cell organelles with important bioenergetic and biosynthetic functions, are important for cell energy production, cell growth, and apoptosis. Mitochondrial DNA is a structure that is particularly susceptible to quantitative (mtDNA copy number variation) and qualitative (sequence variations) alterations that are associated with various types of cancer. Novel biomarkers with diagnostic and prognostic value in cervical cancer can be evaluated to provide higher specificity and complement hrHPV molecular testing, which is the most recommended method for primary screening. In accordance with this, this review aimed to assess mitochondrial alterations associated with cervical cancer in clinical cervicovaginal samples, in order to unravel their possible role as specific diagnostic and prognostic biomarkers for cervical malignancy, and also to guide the understanding of their involvement in carcinogenesis, HPV infection, and disease progression. (© 2024 Environmental Mutagenesis and Genomics Society.) |
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معلومات مُعتمدة: | 310905/2020-6 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 305277/2023-5 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 23109.009436/2023-56 Universidade Federal de Ouro Preto; 23109.016819/2023-81 Universidade Federal de Ouro Preto; 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
فهرسة مساهمة: | Keywords: HPV; cervical cancer; mitochondrial DNA; mitochondrial DNA copy number; mitochondrial DNA mutation |
المشرفين على المادة: | 0 (DNA, Mitochondrial) 0 (Biomarkers, Tumor) |
تواريخ الأحداث: | Date Created: 20240325 Date Completed: 20240523 Latest Revision: 20240524 |
رمز التحديث: | 20240524 |
DOI: | 10.1002/em.22591 |
PMID: | 38523463 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1098-2280 |
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DOI: | 10.1002/em.22591 |