دورية أكاديمية
أعرض في EDS

Qualitative and quantitative changes in mitochondrial DNA associated with cervical cancer: A comprehensive review.

التفاصيل البيبلوغرافية
العنوان: Qualitative and quantitative changes in mitochondrial DNA associated with cervical cancer: A comprehensive review.
المؤلفون: Pereira IOA; School of Pharmacy, UFOP - Federal University of Ouro Preto, Ouro Preto, MG, Brazil., Silva NNT; School of Pharmacy, UFOP - Federal University of Ouro Preto, Ouro Preto, MG, Brazil., Lima AA; School of Pharmacy, UFOP - Federal University of Ouro Preto, Ouro Preto, MG, Brazil., da Silva GN; School of Pharmacy, UFOP - Federal University of Ouro Preto, Ouro Preto, MG, Brazil.
المصدر: Environmental and molecular mutagenesis [Environ Mol Mutagen] 2024 Mar-Apr; Vol. 65 (3-4), pp. 143-152. Date of Electronic Publication: 2024 Mar 24.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8800109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2280 (Electronic) Linking ISSN: 08936692 NLM ISO Abbreviation: Environ Mol Mutagen Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Wiley-Liss
Original Publication: New York, NY : Liss, c1987-
مواضيع طبية MeSH: Uterine Cervical Neoplasms*/genetics , Uterine Cervical Neoplasms*/virology , Uterine Cervical Neoplasms*/pathology , DNA, Mitochondrial*/genetics , DNA Copy Number Variations* , Papillomavirus Infections*/complications , Papillomavirus Infections*/genetics , Papillomavirus Infections*/virology, Humans ; Female ; Mitochondria/genetics ; Mitochondria/metabolism ; Biomarkers, Tumor/genetics ; Prognosis
مستخلص: Cervical cancer is the fourth most commonly diagnosed cancer in women and is considered a preventable disease, as vaccination and screening programs effectively reduce its incidence and mortality rates. Disease physiopathology and malignant cell transformation is a complex process, but it is widely known that high-risk HPV (hrHPV) infection is a necessary risk factor for cancer development. Mitochondria, cell organelles with important bioenergetic and biosynthetic functions, are important for cell energy production, cell growth, and apoptosis. Mitochondrial DNA is a structure that is particularly susceptible to quantitative (mtDNA copy number variation) and qualitative (sequence variations) alterations that are associated with various types of cancer. Novel biomarkers with diagnostic and prognostic value in cervical cancer can be evaluated to provide higher specificity and complement hrHPV molecular testing, which is the most recommended method for primary screening. In accordance with this, this review aimed to assess mitochondrial alterations associated with cervical cancer in clinical cervicovaginal samples, in order to unravel their possible role as specific diagnostic and prognostic biomarkers for cervical malignancy, and also to guide the understanding of their involvement in carcinogenesis, HPV infection, and disease progression.
(© 2024 Environmental Mutagenesis and Genomics Society.)
References: Al‐Awadhi, R., Alroomy, M., Al‐Waheeb, S. & Alwehaidah, M.S. (2023) Altered mitochondrial DNA copy number in cervical exfoliated cells among high‐risk HPV‐positive and HPV‐negative women. Experimental and Therapeutic Medicine, 26(5), 521. Available from: https://doi.org/10.3892/etm.2023.12220.
Allalunis‐Turner, J., Ma, I., Hanson, J. & Pearcey, R. (2006) mtDNA mutations in invasive cervix tumors: a retrospective analysis. Cancer Letters, 243(2), 193–201. Available from: https://doi.org/10.1016/j.canlet.2005.11.035.
Arbyn, M., Ronco, G., Anttila, A., Meijer, C.J.L.M., Poljak, M., Ogilvie, G. et al. (2012) Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer. Vaccine, 30, F88–F99. Available from: https://doi.org/10.1016/j.vaccine.2012.06.095.
Badano, I., Sanabria, D.J., Totaro, M.E., Rubinstein, S., Gili, J.A., Liotta, D.J. et al. (2018) Mitochondrial DNA ancestry, HPV infection and the risk of cervical cancer in a multiethnic population of northeastern Argentina. PLoS One, 13(1), e0190966. Available from: https://doi.org/10.1371/journal.pone.0190966.
Chen, D., Xue, W. & Xiang, J. (2008) The intra‐nucleus integration of mitochondrial DNA (mtDNA)in cervical mucosa cells and its relation with c‐myc expression. Journal of Experimental & Clinical Cancer Research, 27(1), 36. Available from: https://doi.org/10.1186/1756-9966-27-36.
Chen, D. & Zhan, H. (2009) Study on the mutations in the D‐loop region of mitochondrial DNA in cervical carcinoma. Journal of Cancer Research and Clinical Oncology, 135(2), 291–295. Available from: https://doi.org/10.1007/s00432-008-0439-6.
Chinnery, P.F. & Hudson, G. (2013) Mitochondrial genetics. British Medical Bulletin, 106(1), 135–159. Available from: https://doi.org/10.1093/bmb/ldt017.
Fang, H., Shen, L., Chen, T., He, J., Ding, Z., Wei, J. et al. (2010) Cancer type‐specific modulation of mitochondrial haplogroups in breast, colorectal and thyroid cancer. BMC Cancer, 10(1), 421. Available from: https://doi.org/10.1186/1471-2407-10-421.
Feng, D., Xu, H., Li, X., Wei, Y., Jiang, H., Xu, H. et al. (2016) An association analysis between mitochondrial DNA content, G10398A polymorphism, HPV infection, and the prognosis of cervical cancer in the Chinese Han population. Tumor Biology, 37(4), 5599–5607. Available from: https://doi.org/10.1007/s13277-015-4429-4.
Filograna, R., Mennuni, M., Alsina, D. & Larsson, N. (2021) Mitochondrial DNA copy number in human disease: the more the better? FEBS Letters, 595(8), 976–1002. Available from: https://doi.org/10.1002/1873-3468.14021.
Georgescu, S.R., Mitran, C.I., Mitran, M.I., Caruntu, C., Sarbu, M.I., Matei, C. et al. (2018) New insights in the pathogenesis of HPV infection and the associated carcinogenic processes: the role of chronic inflammation and oxidative stress. Journal of Immunology Research, 2018, 1–10. Available from: https://doi.org/10.1155/2018/5315816.
Goia‐Ruşanu, C.D., Iancu, I.V., Botezatu, A., Socolov, D., Huică, I., Pleşa, A. et al. (2011) (2011) mitochondrial DNA mutations in patients with HRHPV‐related cervical lesions. Roumanian Archives of Microbiology and Immunology, 70(1), 5–10.
Gradíssimo, A. & Burk, R.D. (2017) Molecular tests potentially improving HPV screening and genotyping for cervical cancer prevention. Expert Review of Molecular Diagnostics, 17(4), 379–391. Available from: https://doi.org/10.1080/14737159.2017.1293525.
Guardado‐Estrada, M., Medina‐Martínez, I., Juárez‐Torres, E., Roman‐Bassaure, E., Macías, L., Alfaro, A. et al. (2012) The Amerindian mtDNA haplogroup B2 enhances the risk of HPV for cervical cancer: de‐regulation of mitochondrial genes may be involved. Journal of Human Genetics, 57(4), 269–276. Available from: https://doi.org/10.1038/jhg.2012.17.
Gupta, S.M. & Mania‐Pramanik, J. (2019) Retracted article: molecular mechanisms in progression of HPV‐associated cervical carcinogenesis. Journal of Biomedical Science, 26(1), 28. Available from: https://doi.org/10.1186/s12929-019-0520-2.
Hoffmann, A. & Spengler, D. (2018) The mitochondrion as potential interface in early‐life stress brain programming. Frontiers in Behavioral Neuroscience, 12, 306–325. Available from: https://doi.org/10.3389/fnbeh.2018.00306.
IARC – International Agency for Research On Cancer. (2007) Human papillomaviruses: IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 90. Lyon, France: IARC.
Kabekkodu, S.P., Bhat, S., Mascarenhas, R., Mallya, S., Bhat, M., Pandey, D. et al. (2014) Mitochondrial DNA variation analysis in cervical cancer. Mitochondrion, 16, 73–82. Available from: https://doi.org/10.1016/j.mito.2013.07.001.
Kara, M., Tatar, A., Borekci, B., Dagli, F. & Oztas, S. (2012) Mitochondrial DNA 4977 bp deletion in chronic cervicitis and cervix cancers. Balkan Journal of Medical Genetics, 15(1), 25–29. Available from: https://doi.org/10.2478/v10034-012-0004-0.
Lai, D., Tan, C.L., Gunaratne, J., Quek, L.S., Nei, W., Thierry, F. et al. (2013) Localization of HPV‐18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism. PLoS One, 8(9), e75625. Available from: https://doi.org/10.1371/journal.pone.0075625.
Lee, H. (2004) Somatic mutations in the D‐loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 547(1–2), 71–78. Available from: https://doi.org/10.1016/j.mrfmmm.2003.12.011.
Lee, H., Yin, P., Lin, J., Wu, C., Chen, C., Wu, C. et al. (2005) Mitochondrial genome instability and mtDNA depletion in human cancers. Annals of the New York Academy of Sciences, 1042(1), 109–122. Available from: https://doi.org/10.1196/annals.1338.011.
Lee, J.‐E., Chung, Y., Rhee, S. & Kim, T.‐H. (2022) Untold story of human cervical cancers: HPV‐negative cervical cancer. BMB Reports, 55(9), 429–438. Available from: https://doi.org/10.5483/BMBRep.2022.55.9.042.
Li, H.X., Zhong, S. & Li, C.H. (2003) Study on the mitochondrion DNA mutation in tumor tissues of gynecologic oncology patients. Zhonghua Fu Chan Ke Za Zhi, 38(5), 290–293.
Li, N., Franceschi, S., Howell‐Jones, R., Snijders, P.J.F. & Clifford, G.M. (2011) Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication. International Journal of Cancer, 128(4), 927–935. Available from: https://doi.org/10.1002/ijc.25396.
Li, Y., Li, X., Wang, Z., Feng, Z., Li, L. & Ke, X. (2016) Subhaplogroup D4b1 enhances the risk of cervical cancer initiation: a case‐control study in southern China. Journal of Obstetrics and Gynaecology Research, 42(3), 325–330. Available from: https://doi.org/10.1111/jog.12879.
Liberti, M.V. & Locasale, J.W. (2016) The Warburg effect: how does it benefit cancer cells? Trends in Biochemical Sciences, 41(3), 211–218. Available from: https://doi.org/10.1016/j.tibs.2015.12.001.
Nunnari, J. & Suomalainen, A. (2012) Mitochondria: in sickness and in health. Cell, 148(6), 1145–1159. Available from: https://doi.org/10.1016/j.cell.2012.02.035.
Oyouni, A.A.A. (2023) Human papillomavirus in cancer: infection, disease transmission, and progress in vaccines. Journal of Infection and Public Health, 16(4), 626–631. Available from: https://doi.org/10.1016/j.jiph.2023.02.014.
Parrella, P., Seripa, D., Matera, M.G., Rabitti, C., Rinaldi, M., Mazzarelli, P. et al. (2003) Mutations of the D310 mitochondrial mononucleotide repeat in primary tumors and cytological specimens. Cancer Letters, 190(1), 73–77. Available from: https://doi.org/10.1016/S0304-3835(02)00578-5.
Protasoni, M. & Zeviani, M. (2021) Mitochondrial structure and bioenergetics in normal and disease conditions. International Journal of Molecular Sciences, 22(2), 586. Available from: https://doi.org/10.3390/ijms22020586.
Sharma, H., Singh, A., Sharma, C., Jain, S.K. & Singh, N. (2005) Mutations in the mitochondrial DNA D‐loop region are frequent in cervical cancer. Cancer Cell International, 5, 1–6. Available from: https://doi.org/10.1186/1475-2867-5-34.
Sharma, P. & Sampath, H. (2019) Mitochondrial DNA integrity: role in health and disease. Cells, 8(2), 100. Available from: https://doi.org/10.3390/cells8020100.
Suissa, S., Wang, Z., Poole, J., Wittkopp, S., Feder, J., Shutt, T.E. et al. (2009) Ancient mtDNA genetic variants modulate mtDNA transcription and replication. PLoS Genetics, 5(5), e1000474. Available from: https://doi.org/10.1371/journal.pgen.1000474.
Sun, W., Qin, X., Zhou, J., Xu, M., Lyu, Z., Li, X. et al. (2020) Mitochondrial DNA copy number in cervical exfoliated cells and risk of cervical cancer among HPV‐positive women. BMC Women's Health, 20(1), 139. Available from: https://doi.org/10.1186/s12905-020-01001-w.
Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A. et al. (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. Available from: https://doi.org/10.3322/caac.21660.
Vidaurre, S., Fitzpatrick, C., Burzio, V.A., Briones, M., Villota, C., Villegas, J. et al. (2014) Down‐regulation of the antisense mitochondrial non‐coding RNAs (ncRNAs) is a unique vulnerability of cancer cells and a potential target for cancer therapy. Journal of Biological Chemistry, 289(39), 27182–27198. Available from: https://doi.org/10.1074/jbc.M114.558841.
Villota, C., Campos, A., Vidaurre, S., Oliveira‐Cruz, L., Boccardo, E., Burzio, V.A. et al. (2012) Expression of mitochondrial non‐coding RNAs (ncRNAs) is modulated by high risk human papillomavirus (HPV) oncogenes. Journal of Biological Chemistry, 287(25), 21303–21315. Available from: https://doi.org/10.1074/jbc.M111.326694.
Walboomers, J.M.M., Jacobs, M.V., Manos, M.M., Bosch, F.X., Kummer, J.A., Shah, K.V. et al. (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. The Journal of Pathology, 189(1), 12–19. Available from: https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F.
Wallace, D.C. (2005) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annual Review of Genetics, 39(1), 359–407. Available from: https://doi.org/10.1146/annurev.genet.39.110304.095751.
Wallace, D.C. (2012) Mitochondria and cancer. Nature Reviews Cancer, 12(10), 685–698. Available from: https://doi.org/10.1038/nrc3365.
Warowicka, A., Kwasniewska, A. & Gozdzicka‐Jozefiak, A. (2013) Alterations in mtDNA: a qualitative and quantitative study associated with cervical cancer development. Gynecologic Oncology, 129(1), 193–198. Available from: https://doi.org/10.1016/j.ygyno.2013.01.001.
Warowicka, A., Wołuń‐Cholewa, M., Kwaśniewska, A. & Goździcka‐Józefiak, A. (2020) Alternations in mitochondrial genome in carcinogenesis of HPV positive cervix. Experimental and Molecular Pathology, 117, 104530. Available from: https://doi.org/10.1016/j.yexmp.2020.104530.
WHO – World Health Organization. (2021) WHO guideline for screening and treatment of cervical pre‐cancer lesions for cervical cancer prevention, 2nd edition. Geneva, Switzerland: World Health Organization.
Xu, H., He, W., Jiang, H.‐G., Zhao, H., Peng, X.‐H., Wei, Y.‐H. et al. (2013) Prognostic value of mitochondrial DNA content and G10398A polymorphism in non‐small cell lung cancer. Oncology Reports, 30(6), 3006–3012. Available from: https://doi.org/10.3892/or.2013.2783.
Yang, Y., Karakhanova, S., Hartwig, W., D'Haese, J.G., Philippov, P.P., Werner, J. et al. (2016) Mitochondria and mitochondrial ROS in cancer: novel targets for anticancer therapy. Journal of Cellular Physiology, 231(12), 2570–2581. Available from: https://doi.org/10.1002/jcp.25349.
Yousefi, Z., Aria, H., Ghaedrahmati, F., Bakhtiari, T., Azizi, M., Bastan, R. et al. (2022) An update on human papilloma virus vaccines: history, types, protection, and efficacy. Frontiers in Immunology, 12, 805695. Available from: https://doi.org/10.3389/fimmu.2021.805695.
Zhai, K., Chang, L., Zhang, Q., Liu, B. & Wu, Y. (2011) Mitochondrial C150T polymorphism increases the risk of cervical cancer and HPV infection. Mitochondrion, 11(4), 559–563. Available from: https://doi.org/10.1016/j.mito.2011.02.005.
Zhao, Y., Wang, J., Chen, X. & Wu, Q. (2010) Significance of mutation in the D‐loop region in cervical cancer. The West Indian Medical Journal, 59(3), 291–294.
Zong, W.‐X., Rabinowitz, J.D. & White, E. (2016) Mitochondria and cancer. Molecular Cell, 61(5), 667–676. Available from: https://doi.org/10.1016/j.molcel.2016.02.011.
معلومات مُعتمدة: 310905/2020-6 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 305277/2023-5 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 23109.009436/2023-56 Universidade Federal de Ouro Preto; 23109.016819/2023-81 Universidade Federal de Ouro Preto; 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: HPV; cervical cancer; mitochondrial DNA; mitochondrial DNA copy number; mitochondrial DNA mutation
المشرفين على المادة: 0 (DNA, Mitochondrial)
0 (Biomarkers, Tumor)
تواريخ الأحداث: Date Created: 20240325 Date Completed: 20240523 Latest Revision: 20240524
رمز التحديث: 20240524
DOI: 10.1002/em.22591
PMID: 38523463
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-2280
DOI:10.1002/em.22591