دورية أكاديمية
أعرض في EDS

Factors Influencing the Outcome of Patients with Primary Ewing Sarcoma of the Sacrum.

التفاصيل البيبلوغرافية
العنوان: Factors Influencing the Outcome of Patients with Primary Ewing Sarcoma of the Sacrum.
المؤلفون: Rechl V; Pediatrics III, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Ranft A; Pediatrics III, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; German Cancer Consortium, Partnersite, Essen, Germany., Bhadri V; Chris O'Brien Lifehouse, Camperdown, Australia.; Faculty of Medicine and Health, University of Sydney, Camperdown, Australia., Brichard B; Cliniques Universitaires Saint Luc, Department of Pediatric Hematology and Oncology, Université Catholique de Louvain, Brussels, Belgium., Collaud S; Lung Clinic, Department of Thoracic Surgery, Cologne Merheim Hospital, University of Witten/Herdecke, Witten, Germany., Cyprova S; Charles University, Motol Child Ren's Hospital, Prague, Czech Republic., Eich H; Radiotherapy and Radiooncology, University Hospital Muenster, West German Cancer Center Network, Muenster, Germany., Ek T; Childhood Cancer Center Queen Silvia Children's Hospital, Gothenburg, Sweden., Gelderblom H; Leiden University Medical Center, Department of Medical Oncology, Leiden, NL, USA., Hardes J; German Cancer Consortium, Partnersite, Essen, Germany.; Clinic of Tumororthopedics, University Hospital Essen, West German Cancer Centre, Essen, Germany., Haveman LM; Princess Máxima Center for Pediatric Oncology, Department of Solid Tumors, Utrecht, Netherlands., Hartmann W; Gerhard Domagk Institute for Pathology, University Hospital Muenster, West German Cancer Center Network, Muenster, Germany., Hauser P; Velkey László Child's, Health Center, Borsod-Abaúj-Zemplén County University Teaching Hospital, Miskolc, Hungary., Heesen P; Pediatrics III, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Jürgens H; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, West German Cancer Center Network, Münster, Germany., Kanerva J; HUS Helsinki University Hospital, New Children's Hospital, Div. Hematology and Stem Cell Transplantation, Helsinki, Finland., Kühne T; Department of Oncology/Hematology, University Children's Hospital Basel, Basel, Switzerland., Raciborska A; Mother and Child Institute, Department of Oncology and Surgical Oncology for Children and Youth, Warsaw, Poland., Rascon J; Center for Pediatric Oncology and Hematology, Vilnius University Hospital Santaros Klinikos, Vilnius University, Vilnius, Lithuania.; Clinics of Children's Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania., Streitbürger A; German Cancer Consortium, Partnersite, Essen, Germany.; Clinic of Tumororthopedics, University Hospital Essen, West German Cancer Centre, Essen, Germany., Uhlenbruch Y; Patient Representative, St. Josef's Hospital Bochum, University Hospital, Bochum, Germany., Timmermann B; German Cancer Consortium, Partnersite, Essen, Germany.; Clinic for Particle Therapy, West German Proton Beam Centre, University Hospital Essen, West German Cancer Centre, German Cancer Research Centre (DKTK), Essen, Germany., Kersting J; Pediatrics III, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; German Cancer Consortium, Partnersite, Essen, Germany., Pham MT; Pediatrics III, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Dirksen U; Pediatrics III, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; German Cancer Consortium, Partnersite, Essen, Germany.
المصدر: Sarcoma [Sarcoma] 2024 Mar 16; Vol. 2024, pp. 4751914. Date of Electronic Publication: 2024 Mar 16 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Country of Publication: Egypt NLM ID: 9709257 Publication Model: eCollection Cited Medium: Print ISSN: 1357-714X (Print) Linking ISSN: 1357714X NLM ISO Abbreviation: Sarcoma Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: <2006->: Cairo, Egypt : Hindawi Publishing
Original Publication: Abingdon, UK : Carfax Pub. Co., c1997-
مستخلص: Background: Ewing sarcoma (EwS) is a rare and highly malignant bone tumor primarily affecting children, adolescents, and young adults. The pelvis, trunk, and lower extremities are the most common sites, while EwS of the sacrum as a primary site is very rare, and only few studies focusing on this location are published. Due to the anatomical condition, local treatment is challenging in sacral malignancies. We analyzed factors that might influence the outcome of patients suffering from sacral EwS.
Methods: We retrospectively analyzed data of the GPOH EURO-E.W.I.N.G 99 trial and the EWING 2008 trial, with a cohort of 124 patients with localized or metastatic sacral EwS. The study endpoints were overall survival (OS) and event-free survival (EFS). OS and EFS were calculated using the Kaplan-Meier method, and univariate comparisons were estimated using the log-rank test. Hazard ratios (HRs) with respective 95% confidence intervals (CIs) were estimated in a multivariable Cox regression model.
Results: The presence of metastases (3y-EFS: 0.33 vs. 0.68; P < 0.001; HR = 3.4, 95% CI 1.7 to 6.6; 3y-OS: 0.48 vs. 0.85; P < 0.001; HR = 4.23, 95% CI 1.8 to 9.7), large tumor volume (≥200 ml) (3y-EFS: 0.36 vs. 0.69; P =0.02; HR = 2.1, 95% CI 1.1 to 4.0; 3y-OS: 0.42 vs. 0.73; P =0.04; HR = 2.1, 95% CI 1.03 to 4.5), and age ≥18 years (3y-EFS: 0.41 vs. 0.60; P =0.02; HR = 2.6, 95% CI 1.3 to 5.2; 3y-OS: 0.294 vs. 0.59; P =0.01; HR = 2.92, 95% CI 1.29 to 6.6) were revealed as adverse prognostic factors.
Conclusion: Young age seems to positively influence patients` survival, especially in patients with primary metastatic disease. In this context, our results support other studies, stating that older age has a negative impact on survival. Tumor volume, metastases, and the type of local therapy modality have an impact on the outcome of sacral EwS. Level of evidence: Level 2. This trial is registered with NCT00020566 and NCT00987636.
Competing Interests: The authors declare that there are no conflicts of interest.
(Copyright © 2024 Victor Rechl et al.)
References: Sarcoma. 2011;2011:863210. (PMID: 21151650)
J Surg Oncol. 2022 Sep;126(3):577-587. (PMID: 35585834)
J Surg Oncol. 2001 Apr;76(4):301-7. (PMID: 11320524)
J Clin Oncol. 2019 Dec 1;37(34):3192-3202. (PMID: 31553693)
J Orthop Surg Res. 2020 Nov 16;15(1):534. (PMID: 33198775)
J Clin Med. 2021 Apr 14;10(8):. (PMID: 33919988)
Cancer Med. 2019 Mar;8(3):1086-1094. (PMID: 30790456)
Rev Bras Ortop. 2015 Dec 08;47(4):446-50. (PMID: 27047848)
Pediatr Blood Cancer. 2006 Jul;47(1):22-9. (PMID: 16572419)
J Clin Oncol. 2018 Sep 6;:JCO2018782516. (PMID: 30188789)
Klin Padiatr. 1999 Jul-Aug;211(4):271-5. (PMID: 10472561)
Clin Orthop Relat Res. 2000 Apr;(373):193-201. (PMID: 10810477)
J Surg Oncol. 2003 Jul;83(3):154-60. (PMID: 12827683)
Pediatr Blood Cancer. 2011 Oct;57(4):549-53. (PMID: 21442722)
J Clin Oncol. 2010 Jul 10;28(20):3284-91. (PMID: 20547982)
Cancer. 2009 Aug 1;115(15):3526-36. (PMID: 19548262)
J Bone Joint Surg Am. 2016 Feb 3;98(3):199-210. (PMID: 26842410)
Eur J Cancer. 2023 Oct;192:113260. (PMID: 37595489)
Acta Orthop Traumatol Turc. 2020 Jan;54(1):42-48. (PMID: 32175896)
Surg Oncol. 2018 Dec;27(4):603-610. (PMID: 30449479)
Pediatr Blood Cancer. 2018 Sep;65(9):e27251. (PMID: 29856530)
Surg Oncol. 2016 Mar;25(1):16-23. (PMID: 26979636)
Eur J Cancer. 2011 Sep;47 Suppl 3:S366-7. (PMID: 21944018)
Pediatr Blood Cancer. 2021 May;68 Suppl 2:e28355. (PMID: 33818887)
J Clin Oncol. 2000 Sep;18(17):3108-14. (PMID: 10963639)
J Clin Oncol. 2014 Aug 10;32(23):2440-8. (PMID: 24982464)
Immunotherapy. 2021 Dec;13(17):1439-1451. (PMID: 34670399)
Clin Orthop Relat Res. 2020 Feb;478(2):290-302. (PMID: 31580267)
Clin Sarcoma Res. 2018 Mar 30;8:6. (PMID: 29610659)
J Clin Oncol. 2001 Mar 15;19(6):1818-29. (PMID: 11251014)
Cancer. 2002 Jan 15;94(2):561-9. (PMID: 11900241)
Cancers (Basel). 2021 Mar 10;13(6):. (PMID: 33801953)
J Pediatr Hematol Oncol. 2003 Feb;25(2):118-24. (PMID: 12571462)
Ann Oncol. 1999 Sep;10(9):1073-7. (PMID: 10572605)
J Clin Oncol. 2022 Jul 20;40(21):2307-2320. (PMID: 35427190)
J Clin Med. 2021 Aug 17;10(16):. (PMID: 34441922)
J Pediatr Hematol Oncol. 2008 Jun;30(6):425-30. (PMID: 18525458)
Cancer. 1979 Mar;43(3):1001-6. (PMID: 106949)
J Cancer Res Clin Oncol. 2021 Feb;147(2):393-401. (PMID: 33104883)
Pediatr Hematol Oncol. 2012 Feb;29(1):1-11. (PMID: 22295994)
Cancer. 2010 Jan 15;116(2):443-50. (PMID: 19924786)
Acta Oncol. 2006;45(4):469-75. (PMID: 16760184)
Spine (Phila Pa 1976). 2012 Mar 1;37(5):420-8. (PMID: 22366943)
Pathol Oncol Res. 2020 Oct;26(4):2057-2066. (PMID: 31656020)
J Clin Oncol. 2015 Sep 20;33(27):3036-46. (PMID: 26304893)
Bone Rep. 2021 Sep 22;15:101131. (PMID: 34621919)
Skeletal Radiol. 1996 Apr;25(3):302-4. (PMID: 8741073)
سلسلة جزيئية: ClinicalTrials.gov NCT00987636; NCT00020566
تواريخ الأحداث: Date Created: 20240325 Latest Revision: 20240326
رمز التحديث: 20240326
مُعرف محوري في PubMed: PMC10960648
DOI: 10.1155/2024/4751914
PMID: 38524902
قاعدة البيانات: MEDLINE
الوصف
تدمد:1357-714X
DOI:10.1155/2024/4751914