دورية أكاديمية
أعرض في EDS

Exploring the therapeutic potential of pomegranate juice for uterine relaxation.

التفاصيل البيبلوغرافية
العنوان: Exploring the therapeutic potential of pomegranate juice for uterine relaxation.
المؤلفون: Al-Habib OAM; Department of Biology, College of Science, University of Nawroz, Duhok, Kurdistan Region, Iraq., Adam LN; Department of Biology, College of Science, University of Zakho, Duhok, Kurdistan Region, Iraq.
المصدر: Expert review of endocrinology & metabolism [Expert Rev Endocrinol Metab] 2024 Jul; Vol. 19 (4), pp. 377-384. Date of Electronic Publication: 2024 Mar 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278293 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8417 (Electronic) Linking ISSN: 17446651 NLM ISO Abbreviation: Expert Rev Endocrinol Metab Subsets: MEDLINE
أسماء مطبوعة: Publication: <2014- > : London : Taylor & Francis
Original Publication: London, UK : Future Drugs Ltd., c2006-
مواضيع طبية MeSH: Fruit and Vegetable Juices* , Pomegranate*/chemistry , Uterine Contraction*/drug effects , Muscle Relaxation*/drug effects, Female ; Animals ; Rats ; Myometrium/drug effects ; Rats, Sprague-Dawley ; Uterus/drug effects ; Potassium Chloride/pharmacology ; Nitric Oxide/metabolism ; Indomethacin/pharmacology
مستخلص: Background: The effects of pomegranate juice (PJ) and its components on uterine smooth muscle are unknown. Hence, this study unequivocally demonstrates that pomegranate juice (PJ) significantly impacts myometrial function, providing crucial insights into its relaxant properties and their potential therapeutic applications for uterine-related disorders.
Research Design and Methods: Rat uterine smooth muscle horn strips were suspended in Krebs solution organ baths. Contractions were measured isometrically using a transducer (AD instrument Australia). The effects of PJ were evaluated on contractile activity elicited by potassium chloride (KCl 60 Mm) depolarization. Inhibitors of nitric oxide (L-NAME 3 X 10 -4 ), guanylate cyclase (methylene blue 1 X 10 -5 ), and Prostaglandin I 2 (indomethacin 3 X 10 -5 ), as well as Potassium Channels blockers, were determined.
Results: The juice at concentrations from 1.5-5 mg/ml significantly decreased the rat uterine horn contraction induced by KCl. The NO, cGMP, and PGI 2 inhibitors did not block the relaxation response. Furthermore, the PGI 2 inhibitor significantly enhanced the relaxation effects; K + channel blockers had no inhibitory effects on the relaxation responses. Contrarily, GLIB improved considerably relaxation.
Conclusion: Research suggests pomegranate juice's active ingredient may reduce uterine contractions and treat uterotonic disorders, potentially preventing preterm birth and dysmenorrhea. Further research is needed to determine its mechanism of action.
Trial Registration: Code: AEC-013.
فهرسة مساهمة: Keywords: Ca++-channels blocker; K+-channels blockers; L-NAME; Pomegranate juice; rat uterine horns
المشرفين على المادة: 660YQ98I10 (Potassium Chloride)
31C4KY9ESH (Nitric Oxide)
XXE1CET956 (Indomethacin)
تواريخ الأحداث: Date Created: 20240325 Date Completed: 20240620 Latest Revision: 20240620
رمز التحديث: 20240620
DOI: 10.1080/17446651.2024.2334218
PMID: 38525817
قاعدة البيانات: MEDLINE
الوصف
تدمد:1744-8417
DOI:10.1080/17446651.2024.2334218