دورية أكاديمية
أعرض في EDS

Intra and peritumoral PET radiomics analysis to predict the pathological response in breast cancer patients receiving neoadjuvant chemotherapy.

التفاصيل البيبلوغرافية
العنوان: Intra and peritumoral PET radiomics analysis to predict the pathological response in breast cancer patients receiving neoadjuvant chemotherapy.
المؤلفون: Aksu A; İzmir Kâtip Çelebi University, Atatürk Training and Research Hospital, Department of Nuclear Medicine, İzmir, Turkey. Electronic address: aaysegulgedikli@gmail.com., Güç ZG; İzmir Kâtip Çelebi University, Atatürk Training and Research Hospital, Department of Medical Oncology, İzmir, Turkey., Küçüker KA; İzmir Kâtip Çelebi University, Atatürk Training and Research Hospital, Department of Nuclear Medicine, İzmir, Turkey., Alacacıoğlu A; İzmir Kâtip Çelebi University, Atatürk Training and Research Hospital, Department of Medical Oncology, İzmir, Turkey., Turgut B; İzmir Kâtip Çelebi University, Atatürk Training and Research Hospital, Department of Nuclear Medicine, İzmir, Turkey.
المصدر: Revista espanola de medicina nuclear e imagen molecular [Rev Esp Med Nucl Imagen Mol (Engl Ed)] 2024 May-Jun; Vol. 43 (3), pp. 500002. Date of Electronic Publication: 2024 Mar 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier España Country of Publication: Spain NLM ID: 101770941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2253-8089 (Electronic) Linking ISSN: 22538089 NLM ISO Abbreviation: Rev Esp Med Nucl Imagen Mol (Engl Ed) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Barcelona] : Elsevier España, ©2012-
مواضيع طبية MeSH: Breast Neoplasms*/diagnostic imaging , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Neoadjuvant Therapy* , Fluorodeoxyglucose F18* , Radiopharmaceuticals* , Carcinoma, Ductal, Breast*/diagnostic imaging , Carcinoma, Ductal, Breast*/drug therapy , Carcinoma, Ductal, Breast*/pathology, Humans ; Female ; Middle Aged ; Retrospective Studies ; Adult ; Aged ; Positron-Emission Tomography ; Treatment Outcome ; Chemotherapy, Adjuvant ; Radiomics
مستخلص: Objective: The aim of our study was to evaluate the contribution of 18Fluorine-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) radiomic data obtained from both the tumoral and peritumoral area in predicting pathological complete response (pCR) in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy (NAC).
Methods: Female patients with a diagnosis of invasive ductal carcinoma who received NAC were evaluated retrospectively. The volume of interest (VOI) of the primary tumor (VOI- T ) was manually segmented, then a voxel-thick VOI was added around VOI- T to define the peritumoral area (VOI- PT ). Morphological, intensity-based, histogram and texture parameters were obtained from VOIs. The patients were divided into two groups as pCR and non-complete pathological response (npCR). A "radiomic model" was created with only radiomic features, and a "patho-radiomic model" was created using radiomic features and immunohistochemical data.
Results: Of the 66 patients included in the study, 21 were in the pCR group. The only statistically significant feature from the primary tumor among patients with pCR and npCR was Morphological_Compacity- T (AUC: 0.666). Between response groups, a significant difference was detected in 2 morphological, 1 intensity, 4 texture features from VOI- PT ; no correlation was found between Morphological_Compacity- PT and NGTDM_contrast- PT . The obtained radiomic model's sensitivity and accuracy values were calculated as 61.9% and 75.8%, respectively (AUC: 0.786). When HER2 status was added, sensitivity and accuracy values of the patho-radiomic model increased to 85.7% and 81.8%, respectively (AUC: 0.903).
Conclusions: Evaluation of PET peritumoral radiomic features together with the primary tumor, rather than just the primary tumor, provides a better prediction of the pCR to NAC in patients with breast cancer.
(Copyright © 2024 Sociedad Española de Medicina Nuclear e Imagen Molecular. Published by Elsevier España, S.L.U. All rights reserved.)
فهرسة مساهمة: Keywords: Breast cancer; Cáncer de mama; FDG PET; Neoadjuvant chemotherapy; PET con FDG; Peritumoral; Quimioterapia neoadyuvante; Radiomics; Radiómica
المشرفين على المادة: 0Z5B2CJX4D (Fluorodeoxyglucose F18)
0 (Radiopharmaceuticals)
تواريخ الأحداث: Date Created: 20240325 Date Completed: 20240522 Latest Revision: 20240522
رمز التحديث: 20240523
DOI: 10.1016/j.remnie.2024.500002
PMID: 38527731
قاعدة البيانات: MEDLINE
الوصف
تدمد:2253-8089
DOI:10.1016/j.remnie.2024.500002