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Nonalcoholic Fatty Liver Disease and Associated Risk Factors in Obese Nigerians: A Cross-Sectional Study.

التفاصيل البيبلوغرافية
العنوان: Nonalcoholic Fatty Liver Disease and Associated Risk Factors in Obese Nigerians: A Cross-Sectional Study.
المؤلفون: Onyia CP; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria., Asogwa P; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria., Adiri W; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria., Obienu O; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria., Ijoma UN; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.; Department of Medicine, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu, Nigeria., Nwokediuko SC; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria.; Department of Medicine, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu, Nigeria., Okeke EN; Department of Medicine, Jos University Teaching Hospital, Plateau State, Nigeria.
المصدر: Nigerian journal of clinical practice [Niger J Clin Pract] 2024 Mar 01; Vol. 27 (3), pp. 352-360. Date of Electronic Publication: 2024 Mar 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Medknow Publications Country of Publication: India NLM ID: 101150032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1119-3077 (Print) NLM ISO Abbreviation: Niger J Clin Pract Subsets: MEDLINE
أسماء مطبوعة: Publication: Mumbai : Medknow Publications
Original Publication: [Lagos?] : Medical and Dental Consultants' Association of Nigeria
مواضيع طبية MeSH: Non-alcoholic Fatty Liver Disease*/epidemiology , Non-alcoholic Fatty Liver Disease*/complications , Diabetes Mellitus*/epidemiology , Hypertension*/epidemiology , Hypertension*/complications , Liver Neoplasms* , West African People*, Humans ; Cross-Sectional Studies ; Blood Glucose/metabolism ; Body Mass Index ; Risk Factors ; Obesity/complications ; Obesity/epidemiology ; Obesity/metabolism ; Prevalence
مستخلص: Background: Nonalcoholic fatty liver disease (NAFLD) is now adjudged the most common liver disease in the world, contributing to the rising incidence of hepatocellular carcinoma worldwide. However, the true prevalence of nonalcoholic fatty liver disease among obese individuals and its contribution to the burden of liver disease in Nigeria is unknown.
Aim: To determine the prevalence of nonalcoholic fatty liver disease and associated risk factors in obese subjects.
Methods: This was a cross-sectional analytical study of 280 obese subjects and 280 nonobese age and sex-matched controls seen at our health facility. Data collection was done using an interviewer-administered questionnaire and anthropometric parameters were obtained. Fasting blood samples were collected for blood glucose, lipid profile, and liver biochemistry. Abdominal ultrasound was used to screen for NAFLD. The results were subjected to relevant statistical analysis using SPSS version 20.
Results: A higher prevalence of NAFLD was found in obese subjects, compared with nonobese controls (36.4% versus 0.4% P < 0.001). The degree of obesity, transaminases, total cholesterol, diastolic hypertension, fasting blood glucose, and waist circumference was significantly associated with a higher prevalence of NAFLD. However, using multivariate logistic regression analysis, diabetes mellitus and hypertension were significant associations for NAFLD. Individuals with NAFLD had a significantly higher prevalence of metabolic syndrome 65.9%, compared with 34.1% in obese individuals without NAFLD (P < 0.001).
Conclusion: The prevalence of NAFLD in obese subjects was significant. NAFLD in obese subjects was associated with degree of obesity, hyperlipidemia, hypertension, and diabetes mellitus.
(Copyright © 2024 Copyright: © 2024 Nigerian Journal of Clinical Practice.)
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المشرفين على المادة: 0 (Blood Glucose)
تواريخ الأحداث: Date Created: 20240326 Date Completed: 20240327 Latest Revision: 20240327
رمز التحديث: 20240327
DOI: 10.4103/njcp.njcp_365_23
PMID: 38528356
قاعدة البيانات: MEDLINE
الوصف
تدمد:1119-3077
DOI:10.4103/njcp.njcp_365_23