دورية أكاديمية
Branching Crisscross Polymerization of Single-Stranded DNA Slats.
| العنوان: | Branching Crisscross Polymerization of Single-Stranded DNA Slats. |
|---|---|
| المؤلفون: | Deng J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Minev D; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Ershova A; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States., Shih WM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, Massachusetts 02115, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States. |
| المصدر: | Journal of the American Chemical Society [J Am Chem Soc] 2024 Apr 03; Vol. 146 (13), pp. 9216-9223. Date of Electronic Publication: 2024 Mar 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| مواضيع طبية MeSH: | DNA, Single-Stranded*, Polymerization |
| مستخلص: | Controlling where and when self-assembly happens is crucial in both biological and synthetic systems as it optimizes the utilization of available resources. We previously reported strictly seed-initiated linear crisscross polymerization with alternating recruitment of single-stranded DNA slats that are aligned in a parallel versus perpendicular orientation with respect to the double-helical axes. However, for some applications, it would be advantageous to produce growth that is faster than what a linear assembly can provide. Here, we implement crisscross polymerization with alternating sets of six parallel slats versus six perpendicular slats and use this framework to explore branching behavior. We present architectures that, respectively, are designed to exhibit primary, secondary, and hyperbranching growth. Thus, amplification via nonlinear crisscross polymerization can provide a route for applications such as low-cost, enzyme-free, and ultrasensitive detection. |
| المشرفين على المادة: | 0 (DNA, Single-Stranded) |
| تواريخ الأحداث: | Date Created: 20240326 Date Completed: 20240404 Latest Revision: 20240404 |
| رمز التحديث: | 20240404 |
| DOI: | 10.1021/jacs.4c00097 |
| PMID: | 38529625 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5126 |
|---|---|
| DOI: | 10.1021/jacs.4c00097 |