دورية أكاديمية
Current challenges in xenotransplantation.
| العنوان: | Current challenges in xenotransplantation. |
|---|---|
| المؤلفون: | Vadori M; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua., Cozzi E; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua.; Transplant Immunology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health Padua University Hospital, Padua, Italy. |
| المصدر: | Current opinion in organ transplantation [Curr Opin Organ Transplant] 2024 Jun 01; Vol. 29 (3), pp. 205-211. Date of Electronic Publication: 2024 Apr 16. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9717388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-7013 (Electronic) Linking ISSN: 10872418 NLM ISO Abbreviation: Curr Opin Organ Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Philadelphia, PA : Rapid Science Publishers, |
| مواضيع طبية MeSH: | Graft Rejection*/immunology , Graft Rejection*/prevention & control , Transplantation, Heterologous*, Animals ; Humans ; Animals, Genetically Modified ; Graft Survival ; Heterografts ; Immunosuppressive Agents/therapeutic use ; Immunosuppressive Agents/adverse effects ; Swine ; Treatment Outcome |
| مستخلص: | Purpose of Review: In recent years, the xenotransplantation science has advanced tremendously, with significant strides in both preclinical and clinical research. This review intends to describe the latest cutting-edge progress in knowledge and methodologies developed to overcome potential obstacles that may preclude the translation and successful application of clinical xenotransplantation. Recent Findings: Preclinical studies have demonstrated that it is now possible to extend beyond two years survival of primate recipients of life saving xenografts. This has been accomplished thanks to the utilization of genetic engineering methodologies that have allowed the generation of specifically designed gene-edited pigs, a careful donor and recipient selection, and appropriate immunosuppressive strategies.In this light, the compassionate use of genetically modified pig hearts has been authorized in two human recipients and xenotransplants have also been achieved in human decedents. Although encouraging the preliminary results suggest that several challenges have yet to be fully addressed for a successful clinical translation of xenotransplantation. These challenges include immunologic, physiologic and biosafety aspects. Summary: Recent progress has paved the way for the initial compassionate use of pig organs in humans and sets the scene for a wider application of clinical xenotransplantation. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.) |
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| تواريخ الأحداث: | Date Created: 20240326 Date Completed: 20240429 Latest Revision: 20240604 |
| رمز التحديث: | 20240604 |
| مُعرف محوري في PubMed: | PMC11064916 |
| DOI: | 10.1097/MOT.0000000000001146 |
| PMID: | 38529696 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1531-7013 |
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| DOI: | 10.1097/MOT.0000000000001146 |