دورية أكاديمية
أعرض في EDS

Infectious mononucleosis: new concepts in clinical presentation, epidemiology, and host response.

التفاصيل البيبلوغرافية
العنوان: Infectious mononucleosis: new concepts in clinical presentation, epidemiology, and host response.
المؤلفون: Naughton P; Department of Biological Sciences, Munster Technological University, Rossa Avenue, Bishopstown.; Department of Haematology., Enright F; Department of Paediatrics, Mercy University Hospital, Grenville Place, Cork, Ireland., Lucey B; Department of Biological Sciences, Munster Technological University, Rossa Avenue, Bishopstown.
المصدر: Current opinion in infectious diseases [Curr Opin Infect Dis] 2024 Jun 01; Vol. 37 (3), pp. 157-163. Date of Electronic Publication: 2024 Mar 26.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8809878 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-6527 (Electronic) Linking ISSN: 09517375 NLM ISO Abbreviation: Curr Opin Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, Md. : Lippincott Williams & Wilkins
Original Publication: London, UK ; Philadelphia, PA : Gower Academic Journals, c1988-
مواضيع طبية MeSH: Infectious Mononucleosis*/epidemiology , Infectious Mononucleosis*/diagnosis, Humans ; Herpesvirus 4, Human/immunology ; Autoimmune Diseases/epidemiology
مستخلص: Purpose of Review: Infectious mononucleosis (IM) is an infectious disease that presents clinically in only a small percentage of individuals despite almost universal infection with the causative agent. Here, we review the latest concepts in the clinical presentation, epidemiology, and host response of this disease.
Recent Findings: Several recently published papers/reviews describe IM as a condition caused by one of several etiologic agents including, cytomegalovirus (HHV-5), Roseola virus (HHV-6) and Toxoplasmosis amongst others; this review focuses on IM as solely caused by the human herpes virus 4 (HHV-4). Since the initial discovery of the virus in the 1960s and its subsequent discovery as the primary etiologic agent for IM it has been associated with several human cancers and autoimmune disorders. Recent published findings show a correlation between HHV-4 and the autoimmune disorder, multiple sclerosis (MS), suggesting earlier IM could possibly act as a causative factor. Considering the important links being made with IM to so many cancers and autoimmune disorders it is surprising that a standard investigative procedure has yet to be determined for this disease. A standard approach to the investigation of IM would ensure more cases are diagnosed, particularly atypical cases, this would benefit epidemiological studies, and more immediately help practitioners distinguish viral from bacterial throat infections, enabling them to treat accordingly.
Summary: The understanding of the latest concepts in clinical presentation, epidemiology and host response to IM would benefit greatly from the introduction of a standard procedure for its investigation and diagnosis.
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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تواريخ الأحداث: Date Created: 20240326 Date Completed: 20240424 Latest Revision: 20240603
رمز التحديث: 20240603
DOI: 10.1097/QCO.0000000000001012
PMID: 38529804
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-6527
DOI:10.1097/QCO.0000000000001012