دورية أكاديمية
Chemically synthesized ciprofloxacin-PEG-FeO nanotherapeutic exhibits strong antibacterial and controlled cytotoxic effects.
| العنوان: | Chemically synthesized ciprofloxacin-PEG-FeO nanotherapeutic exhibits strong antibacterial and controlled cytotoxic effects. |
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| المؤلفون: | Hussan; Department of Microbiology, University of Haripur, Khyber Pakhtunkhwa, 22620, Pakistan., Nisa S; Department of Microbiology, University of Haripur, Khyber Pakhtunkhwa, 22620, Pakistan., Bano SA; Department of Microbiology, University of Haripur, Khyber Pakhtunkhwa, 22620, Pakistan., Zia M; Department of Biotechnology, Quaid e Azam University Islamabad, Islamabad, 15320, Pakistan. |
| المصدر: | Nanomedicine (London, England) [Nanomedicine (Lond)] 2024 Apr; Vol. 19 (10), pp. 875-893. Date of Electronic Publication: 2024 Mar 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 101278111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-6963 (Electronic) Linking ISSN: 17435889 NLM ISO Abbreviation: Nanomedicine (Lond) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, UK : Future Medicine Ltd., c2006- |
| مواضيع طبية MeSH: | Staphylococcal Infections*/drug therapy , Antineoplastic Agents*/therapeutic use , Nanoparticles*, Cricetinae ; Animals ; Mice ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use |
| مستخلص: | Aim: To develop a biocompatible conjugated ciprofloxacin-PEG-FeO nanodelivery system with increased efficacy of available therapeutics in a controlled manner. Materials & methods: FeO nanoparticles were synthesized by chemical and biological methods and modified as ciprofloxacin-PEG-FeO nanoformulations. After initial antibacterial and cytotoxicity studies, the effective and biocompatible nanoformulations was further fabricated as nanotherapeutics for in vivo studies in mouse models. Results: Chemically synthesized ciprofloxacin-PEG-FeO nanoformulations demonstrated boosted antibacterial activity against clinically isolated bacterial strains. Nanoformulations were also found to be compatible with baby hamster kidney 21 cells and red blood cells. In in vivo studies, nanotherapeutic showed wound-healing effects with eradication of Staphylococcus aureus infection. Conclusion: The investigations indicate that the developed nanotherapeutic can eradicate localized infections and enhance wound healing with controlled cytotoxicity. |
| فهرسة مساهمة: | Keywords: CIP-PEG-FeO nanoformulation; antibacterial; controlled cytotoxicity; mouse model; therapeutic agents |
| المشرفين على المادة: | 5E8K9I0O4U (Ciprofloxacin) 0 (Anti-Bacterial Agents) 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20240326 Date Completed: 20240329 Latest Revision: 20240422 |
| رمز التحديث: | 20240422 |
| DOI: | 10.2217/nnm-2023-0298 |
| PMID: | 38530883 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1748-6963 |
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| DOI: | 10.2217/nnm-2023-0298 |