دورية أكاديمية
Heart rate variability analysis in obstructive sleep apnea patients with daytime sleepiness.
| العنوان: | Heart rate variability analysis in obstructive sleep apnea patients with daytime sleepiness. |
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| المؤلفون: | Ucak S; Charles Perkins Centre and Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Dissanayake HU; Charles Perkins Centre and Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, NSW, Australia., de Chazal P; Charles Perkins Centre and Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; School of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, NSW, Australia., Bin YS; Charles Perkins Centre and Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, NSW, Australia., Sutherland K; Charles Perkins Centre and Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, NSW, Australia., Setionago B; Charles Perkins Centre and Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Tong B; Charles Perkins Centre and Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, NSW, Australia., Yee BJ; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Kairaitis K; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Ludwig Engel Centre for Respiratory Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.; Department of Respiratory and Sleep Medicine, Westmead Hospital, Sydney, NSW, Australia., Wheatley JR; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Ludwig Engel Centre for Respiratory Research, Westmead Institute for Medical Research, Sydney, NSW, Australia.; Department of Respiratory and Sleep Medicine, Westmead Hospital, Sydney, NSW, Australia., Piper AJ; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Cistulli PA; Charles Perkins Centre and Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, NSW, Australia. |
| مؤلفون مشاركون: | Sydney Sleep Biobank Investigators |
| المصدر: | Sleep [Sleep] 2024 Jun 13; Vol. 47 (6). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 7809084 Publication Model: Print Cited Medium: Internet ISSN: 1550-9109 (Electronic) Linking ISSN: 01618105 NLM ISO Abbreviation: Sleep Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: New York, Raven Press. |
| مواضيع طبية MeSH: | Sleep Apnea, Obstructive*/physiopathology , Sleep Apnea, Obstructive*/complications , Heart Rate*/physiology , Polysomnography* , Electrocardiography*, Humans ; Male ; Female ; Middle Aged ; Adult ; Autonomic Nervous System/physiopathology ; Disorders of Excessive Somnolence/physiopathology |
| مستخلص: | Study Objectives: Recent studies suggest that sleepy patients with obstructive sleep apnea (OSA) are at higher risk for incident cardiovascular disease. This study assessed cardiac autonomic function in sleepy versus non-sleepy patients with OSA using heart rate variability (HRV) analysis. We hypothesized that HRV profiles of sleepy patients would indicate higher cardiovascular risk. Methods: Electrocardiograms (ECG) derived from polysomnograms (PSG) collected by the Sydney Sleep Biobank were used to study HRV in groups of sleepy (ESS ≥ 10) and non-sleepy OSA patients (ESS < 10). HRV parameters were averaged across available ECG signals during N2 sleep. Results: A total of 421 patients were evaluated, with a mean age of 54 (14) years, body mass index of 33 (9) kg/m2, apnea-hypopnea index of 21 (28) events/h, and 66% male. The sleepy group consisted of 119 patients and the non-sleepy group 302 patients. Sleepy patients exhibited lower HRV values for: root mean square successive difference (RMSSD, p = 0.028), total power (TP, p = 0.031), absolute low frequency (LF, p = 0.045), and high-frequency (HF, p = 0.010) power compared to non-sleepy patients. Sleepy patients with moderate-to-severe OSA exhibited lower HRV values for: (RMSSD, p = 0.045; TP, p = 0.052), absolute LF (p = 0.051), and HF power (p = 0.025). There were no differences in other time and frequency domain HRV markers. Conclusions: This study shows a trend toward parasympathetic withdrawal in sleepy OSA patients, particularly in moderate-to-severe cases, lending mechanistic support to the link between the sleepy phenotype and CVD risk in OSA. (© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society.) |
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| فهرسة مساهمة: | Investigator: P Cistulli; P de Chazal; K Sutherland; N Sarkissian; C Moi Chow; A Chan; A Lowth; J Graham; W Wood; G Cohen; C Bennett; M Ahmadi; J Wheatley; K Kairaitis; S Lambert; R Ginn; T Burns; B Yee; A Piper; K Wong; K Melehan; M Chan; D Wang; G Gauthier Keywords: autonomic nervous system; cardiovascular risk; excessive daytime sleepiness; heart rate variability; obstructive sleep apnea |
| تواريخ الأحداث: | Date Created: 20240326 Date Completed: 20240612 Latest Revision: 20240614 |
| رمز التحديث: | 20240614 |
| مُعرف محوري في PubMed: | PMC11168755 |
| DOI: | 10.1093/sleep/zsae075 |
| PMID: | 38531670 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-9109 |
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| DOI: | 10.1093/sleep/zsae075 |