دورية أكاديمية
Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities.
| العنوان: | Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities. |
|---|---|
| المؤلفون: | Stroope C; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA., Nettersheim FS; La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Coon B; Yale Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Cardiovascular Biology Research Program, OMRF, Oklahoma City, OK, USA.; Department of Cell Biology, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA., Finney AC; Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA., Schwartz MA; Yale Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.; Departments of Cell Biology and Biomedical Engineering, Yale University, New Haven, CT, USA., Ley K; La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Bioengineering, University of California, San Diego, San Diego, CA, USA.; Immunology Center of Georgia (IMMCG), Augusta University Immunology Center of Georgia, Augusta, GA, USA., Rom O; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.; Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA., Yurdagul A Jr; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA. arif.yurdagul@lsuhs.edu.; Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA. arif.yurdagul@lsuhs.edu. |
| المصدر: | Nature metabolism [Nat Metab] 2024 Apr; Vol. 6 (4), pp. 617-638. Date of Electronic Publication: 2024 Mar 26. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer Nature, [2019]- |
| مواضيع طبية MeSH: | Atherosclerosis*/metabolism, Humans ; Animals ; Macrophages/metabolism ; Endothelial Cells/metabolism ; Muscle, Smooth, Vascular/metabolism ; T-Lymphocytes/metabolism |
| مستخلص: | Accumulating evidence over the past decades has revealed an intricate relationship between dysregulation of cellular metabolism and the progression of atherosclerotic cardiovascular disease. However, an integrated understanding of dysregulated cellular metabolism in atherosclerotic cardiovascular disease and its potential value as a therapeutic target is missing. In this Review, we (1) summarize recent advances concerning the role of metabolic dysregulation during atherosclerosis progression in lesional cells, including endothelial cells, vascular smooth muscle cells, macrophages and T cells; (2) explore the complexity of metabolic cross-talk between these lesional cells; (3) highlight emerging technologies that promise to illuminate unknown aspects of metabolism in atherosclerosis; and (4) suggest strategies for targeting these underexplored metabolic alterations to mitigate atherosclerosis progression and stabilize rupture-prone atheromas with a potential new generation of cardiovascular therapeutics. (© 2024. Springer Nature Limited.) |
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| معلومات مُعتمدة: | R00 HL150233 United States HL NHLBI NIH HHS; R01 DK134011 United States DK NIDDK NIH HHS; P01 HL136275 United States HL NHLBI NIH HHS; R01 HL135582 United States HL NHLBI NIH HHS; R35 HL145241 United States HL NHLBI NIH HHS; R00 HL145131 United States HL NHLBI NIH HHS; R01 HL167758 United States HL NHLBI NIH HHS; R01 DK136685 United States DK NIDDK NIH HHS |
| تواريخ الأحداث: | Date Created: 20240327 Date Completed: 20240426 Latest Revision: 20240508 |
| رمز التحديث: | 20240509 |
| مُعرف محوري في PubMed: | PMC11055680 |
| DOI: | 10.1038/s42255-024-01015-w |
| PMID: | 38532071 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. | تدمد: | 2522-5812 |
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| DOI: | 10.1038/s42255-024-01015-w |