دورية أكاديمية
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Functional Conservation of the Small GTPase Rho5/Rac1-A Tale of Yeast and Men.

التفاصيل البيبلوغرافية
العنوان: Functional Conservation of the Small GTPase Rho5/Rac1-A Tale of Yeast and Men.
المؤلفون: Bischof L; AG Genetik, Fachbereich Biologie/Chemie, University of Osnabrück, Barbarastrasse 11, D-49076 Osnabrück, Germany., Schweitzer F; AG Genetik, Fachbereich Biologie/Chemie, University of Osnabrück, Barbarastrasse 11, D-49076 Osnabrück, Germany., Heinisch JJ; AG Genetik, Fachbereich Biologie/Chemie, University of Osnabrück, Barbarastrasse 11, D-49076 Osnabrück, Germany.
المصدر: Cells [Cells] 2024 Mar 07; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 07.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Saccharomyces cerevisiae*/metabolism , Monomeric GTP-Binding Proteins*/metabolism, Male ; Humans ; Oxidative Stress ; rho GTP-Binding Proteins/metabolism ; Reactive Oxygen Species/metabolism
مستخلص: Small GTPases are molecular switches that participate in many essential cellular processes. Amongst them, human Rac1 was first described for its role in regulating actin cytoskeleton dynamics and cell migration, with a close relation to carcinogenesis. More recently, the role of Rac1 in regulating the production of reactive oxygen species (ROS), both as a subunit of NADPH oxidase complexes and through its association with mitochondrial functions, has drawn attention. Malfunctions in this context affect cellular plasticity and apoptosis, related to neurodegenerative diseases and diabetes. Some of these features of Rac1 are conserved in its yeast homologue Rho5. Here, we review the structural and functional similarities and differences between these two evolutionary distant proteins and propose yeast as a useful model and a device for high-throughput screens for specific drugs.
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فهرسة مساهمة: Keywords: NADPH oxidase; Rac1; Rho5; apoptosis; glucose signaling; mitochondria; molecular switch; oxidative stress
المشرفين على المادة: EC 3.6.5.2 (Monomeric GTP-Binding Proteins)
EC 3.6.5.2 (rho GTP-Binding Proteins)
0 (Reactive Oxygen Species)
تواريخ الأحداث: Date Created: 20240327 Date Completed: 20240328 Latest Revision: 20240329
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC10969153
DOI: 10.3390/cells13060472
PMID: 38534316
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells13060472