دورية أكاديمية
أعرض في EDS

Frailty as a comprehensive health measure beyond seizure control in patients with epilepsy: A cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Frailty as a comprehensive health measure beyond seizure control in patients with epilepsy: A cross-sectional study.
المؤلفون: Cerulli Irelli E; Department of Human Neurosciences, Sapienza University, Rome, Italy., Borioni MS; Department of Human Neurosciences, Sapienza University, Rome, Italy., Morano A; Department of Human Neurosciences, Sapienza University, Rome, Italy., Mazzeo A; Institute of Research and Medical Care Neuromed, Pozzilli, Italy., Moro P; Department of Human Neurosciences, Sapienza University, Rome, Italy., Orlando B; Department of Human Neurosciences, Sapienza University, Rome, Italy., Salamone EM; Department of Human Neurosciences, Sapienza University, Rome, Italy., Giordano L; Department of Human Neurosciences, Sapienza University, Rome, Italy., Petrungaro A; Department of Human Neurosciences, Sapienza University, Rome, Italy.; Neurorehabilitation Unit, IRCCS Santa Maria Nascente, Don Carlo Gnocchi Foundation, Milan, Italy., Toccaceli Blasi M; Department of Human Neurosciences, Sapienza University, Rome, Italy., Giallonardo AT; Department of Human Neurosciences, Sapienza University, Rome, Italy., Canevelli M; Department of Human Neurosciences, Sapienza University, Rome, Italy.; National Center for Disease Prevention and Health Promotion, Italian National Institute of Health, Rome, Italy.; Aging Research Center, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Di Bonaventura C; Department of Human Neurosciences, Sapienza University, Rome, Italy.; Policlinico Umberto I, Rome, Italy.
المصدر: Epilepsia [Epilepsia] 2024 Jun; Vol. 65 (6), pp. 1658-1667. Date of Electronic Publication: 2024 Mar 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE
أسماء مطبوعة: Publication: Malden, MA : Blackwell Science
Original Publication: Copenhagen : Munskgaard
مواضيع طبية MeSH: Frailty*/diagnosis , Epilepsy*/drug therapy , Epilepsy*/diagnosis , Anticonvulsants*/therapeutic use, Humans ; Male ; Female ; Cross-Sectional Studies ; Middle Aged ; Adult ; Quality of Life ; Seizures/drug therapy ; Aged
مستخلص: Objective: Due to the high clinical heterogeneity of epilepsy, there is a critical need for novel metrics aimed at capturing its biological and phenotypic complexity. Frailty is increasingly recognized in various medical disciplines as a useful construct to understand differences in susceptibility to adverse outcomes. Here, we develop a frailty index (FI) for patients with epilepsy (PwE) and explore its association with demographic and clinical features.
Methods: In this cross-sectional study, we consecutively enrolled 153 PwE from an outpatient epilepsy clinic. Participants were assessed for various health deficits to calculate the FI. Associations between FI and demographic/clinical features, antiseizure medications (ASMs), and patient-reported outcomes were analyzed using general linear models and Spearman correlation.
Results: The median age at the time of study visit was 47 years (interquartile range = 33-60), and 89 (58.2%) patients were females. Multiple linear regression revealed that the developed 33-item FI showed an independent association with age, female sex, higher body mass index, family history of epilepsy, intellectual disability, and the number of ASMs used. A robust analysis of covariance showed higher FI levels in patients using cytochrome P450 3A4-inducer ASMs. We found a moderate positive correlation between FI and psychological distress, lower quality of life, and physical frailty, measured by the Hospital Anxiety and Depression Scale, Quality of Life in Epilepsy Inventory-10, and handgrip strength, respectively. Finally, a weak association was observed between higher FI scores and an increased number of epileptic falls.
Significance: This study highlights the significance of frailty as a comprehensive health measure in epilepsy. It suggests that frailty in this specific population is not only a manifestation of aging but is inherently linked to epilepsy and treatment-related factors. Future research is warranted to validate and refine the FI in diverse epilepsy populations and investigate its impact on specific adverse outcomes in longitudinal studies.
(© 2024 International League Against Epilepsy.)
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فهرسة مساهمة: Keywords: CYP3A4; antiseizure medication (ASM); comorbidities; quality of life (QOLIE); treatment
المشرفين على المادة: 0 (Anticonvulsants)
تواريخ الأحداث: Date Created: 20240327 Date Completed: 20240611 Latest Revision: 20240611
رمز التحديث: 20240612
DOI: 10.1111/epi.17964
PMID: 38536086
قاعدة البيانات: MEDLINE
الوصف
تدمد:1528-1167
DOI:10.1111/epi.17964