دورية أكاديمية
أعرض في EDS

In females, salivary secretion was significantly lower in patients with severe reflux esophagitis than in healthy controls.

التفاصيل البيبلوغرافية
العنوان: In females, salivary secretion was significantly lower in patients with severe reflux esophagitis than in healthy controls.
المؤلفون: Hoshino S; Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan., Momma E; Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan., Koeda M; Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan., Hoshikawa Y; Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan., Tanabe T; Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan., Kawami N; Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan., Kitasako Y; Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan.; Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-Ku, Tokyo, Japan.; Dental Clinic, Ministry of Foreign Affairs, Chiyoda-Ku, Tokyo, Japan., Iwakiri K; Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan. k-iwa@nms.ac.jp.
المصدر: Esophagus : official journal of the Japan Esophageal Society [Esophagus] 2024 Jul; Vol. 21 (3), pp. 383-389. Date of Electronic Publication: 2024 Mar 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Japan NLM ID: 101206627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-9067 (Electronic) Linking ISSN: 16129059 NLM ISO Abbreviation: Esophagus Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Tokyo, Japan : Springer, [2003]-
مواضيع طبية MeSH: Saliva*/metabolism , Esophagitis, Peptic*/metabolism, Humans ; Female ; Male ; Hydrogen-Ion Concentration ; Middle Aged ; Case-Control Studies ; Adult ; Sex Factors ; Severity of Illness Index ; Aged ; Salivation/physiology
مستخلص: Background: The salivary secretion in patients with mild reflux esophagitis (RE) and non-erosive reflux disease is significantly lower in females, but not in males. However, sex differences in salivary secretion in patients with severe RE remain unknown. Therefore, the present study investigated sex differences in saliva secretion in patients with severe RE.
Methods: Subjects consisted of 23 male patients with severe RE, 24 male healthy controls (HCs), 26 female patients with severe RE, and 25 female HCs. Saliva secretion was assessed as follows: each patient chewed sugarless gum for 3 min prior to endoscopy, and the amount and pH of saliva secreted before and after acid loading as an index of the acid-buffering capacity were measured.
Results: In males, no significant differences were observed in the amount of saliva secretion, salivary pH, or the acid-buffering capacity between severe RE patients and HCs. In females, the amount of saliva secretion (severe RE: 2.4 [1.8-4.1], HCs: 5.3 [3.4-7.5], p = 0.0017), salivary pH (severe RE: 7.0 [6.7-7.3], HCs: 7.2 [7.1-7.3], p = 0.0455), and the acid-buffering capacity (severe RE: 5.9 [5.3-6.2], HCs: 6.2 [6.1-6.5], p = 0.0024) were significantly lower in severe RE patients than in HCs.
Conclusion: Among females, the salivary secretion was significantly lower in severe RE patients than in HCs. This reduction in salivary secretion may contribute to the pathophysiology of severe RE in females.
(© 2024. The Author(s), under exclusive licence to The Author(s) under exclusive licence to The Japan Esophageal Society.)
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معلومات مُعتمدة: JP20K082973 Kakenhi
فهرسة مساهمة: Keywords: Saliva secretion; Severe reflux esophagitis; Sex difference
تواريخ الأحداث: Date Created: 20240327 Date Completed: 20240625 Latest Revision: 20240625
رمز التحديث: 20240626
DOI: 10.1007/s10388-024-01052-0
PMID: 38536601
قاعدة البيانات: MEDLINE
الوصف
تدمد:1612-9067
DOI:10.1007/s10388-024-01052-0