دورية أكاديمية
General anesthesia is not associated with dementia in older adults with osteoarthritis for hip/knee replacements, a national population-based nested case-control study.
| العنوان: | General anesthesia is not associated with dementia in older adults with osteoarthritis for hip/knee replacements, a national population-based nested case-control study. |
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| المؤلفون: | Lin Y; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Anesthesiology, Chung Shan Medical University Hospital, Taichung, Taiwan., Chen CC; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Plastic Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan., Dong C; School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Luan YZ; School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Huang JY; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Center for Health Data Science, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: wchinyang@gmail.com., Wei JC; Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan. Electronic address: wei3228@gmail.com., Chiou JY; School of Health Policy and Management, Chung Shan Medical University, Taichung, Taiwan. Electronic address: drchiou@hotmail.com. |
| المصدر: | Journal of clinical anesthesia [J Clin Anesth] 2024 Aug; Vol. 95, pp. 111449. Date of Electronic Publication: 2024 Mar 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 8812166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4529 (Electronic) Linking ISSN: 09528180 NLM ISO Abbreviation: J Clin Anesth Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: New York : Elsevier Original Publication: [Stoneham, MA] : Butterworths, [c1988- |
| مواضيع طبية MeSH: | Anesthesia, General*/adverse effects , Dementia*/epidemiology , Arthroplasty, Replacement, Hip*/adverse effects , Arthroplasty, Replacement, Hip*/statistics & numerical data , Arthroplasty, Replacement, Knee*/adverse effects , Arthroplasty, Replacement, Knee*/statistics & numerical data, Humans ; Female ; Male ; Aged ; Case-Control Studies ; Taiwan/epidemiology ; Aged, 80 and over ; Databases, Factual ; Anesthesia, Conduction/adverse effects ; Anesthesia, Conduction/statistics & numerical data ; Osteoarthritis, Hip/surgery ; Osteoarthritis, Knee/surgery ; Osteoarthritis, Knee/epidemiology |
| مستخلص: | Background: Dementia is a prevalent neurological condition, yet the relationship between dementia and general anesthesia remains uncertain. The study aimed to explore the association between general anesthesia and dementia using a nationwide population-based database. Methods: The study extracted data from Taiwan's national health insurance, which encompassed the records of one million insured residents. A total of 59,817 patients aged 65 years and above, diagnosed with osteoarthritis between 2002 and 2010, were included. Among these patients, 3277 individuals with an initial diagnosis of dementia between 2004 and 2013 were matched with non-dementia patients based on age, gender, and the date of osteoarthritis diagnosis. Following a 1:2 random matching, the case group included 2171 patients with dementia, while the control group consisted of 4342 patients without dementia. The data was analyzed using conditional and unconditional logistic regressions. Results: No significant differences in the odds of dementia were found between individuals exposed to general and regional anesthesia during hip/knee replacement surgeries (OR = 1.11; 95%CI: 0.73-1.70), after adjusting for age, sex, and co-morbidities. Similarly, there were no significant differences in the odds of dementia based on different durations of anesthesia exposure (General: <2 h: OR = 0.91, 95%CI = 0.43-1.92; 2-4 h: OR = 1.21, 95%CI = 0.82-1.79; >4 h: OR = 0.39, 95%CI = 0.15-1.01; compared to no exposure. Regional: <2 h: OR = 1.18, 95%CI = 0.85-1.62; 2-4 h: OR = 0.9, 95%CI = 0.64-1.27; >4 h: OR = 0.55, 95%CI = 0.15-1.96; compared to no exposure). Likewise, no significant differences were observed in the odds of dementia based on the number of replacement surgeries (twice: OR = 0.74, 95%CI = 0.44-1.23, compared to once). Conclusion: Neither general anesthesia nor regional anesthesia in hip/knee surgery was associated with dementia. Different numbers and durations of anesthesia exposure showed no significant differences in the odds for dementia. Competing Interests: Declaration of competing interest The authors declare that they have no conflicts of interest. (Copyright © 2024. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: A national population-based nested case-control study; Dementia; General anesthesia; Hip/knee surgery; Osteoarthritis |
| تواريخ الأحداث: | Date Created: 20240327 Date Completed: 20240427 Latest Revision: 20240427 |
| رمز التحديث: | 20240428 |
| DOI: | 10.1016/j.jclinane.2024.111449 |
| PMID: | 38537392 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-4529 |
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| DOI: | 10.1016/j.jclinane.2024.111449 |