دورية أكاديمية
Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment.
| العنوان: | Subventricular zone stem cell niche injury is associated with intestinal perforation in preterm infants and predicts future motor impairment. |
|---|---|
| المؤلفون: | Epstein AA; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA., Janos SN; Department of Radiology, Duke University School of Medicine, Durham, NC, USA., Menozzi L; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Pegram K; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA., Jain V; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., Bisset LC; Department of Radiology, Duke University School of Medicine, Durham, NC, USA., Davis JT; Department of Radiology, Duke University School of Medicine, Durham, NC, USA., Morrison S; Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Shailaja A; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA., Guo Y; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA., Chao AS; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA., Abdi K; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., Rikard B; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA., Yao J; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Gregory SG; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA; Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA., Fisher K; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA., Pittman R; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA., Erkanli A; Department of Biostatistics & Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Gustafson KE; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA., Carrico CWT; Department of Radiology, Duke University School of Medicine, Durham, NC, USA., Malcolm WF; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA., Inder TE; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Cotten CM; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA., Burt TD; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA; Children's Health and Discovery Initiative, Duke University School of Medicine, Durham, NC, USA., Shinohara ML; Department of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA., Maxfield CM; Department of Radiology, Duke University School of Medicine, Durham, NC, USA. Electronic address: charles.maxfield@duke.edu., Benner EJ; Department of Pediatrics, Division of Neonatology, Duke University School of Medicine, Durham, NC, USA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. Electronic address: eric.benner@duke.edu. |
| المصدر: | Cell stem cell [Cell Stem Cell] 2024 Apr 04; Vol. 31 (4), pp. 467-483.e6. Date of Electronic Publication: 2024 Mar 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, MA : Cell Press |
| مواضيع طبية MeSH: | Intestinal Perforation*/complications , Motor Disorders*/complications , Premature Birth* , Brain Injuries*/complications , Brain Injuries*/diagnostic imaging, Infant ; Female ; Infant, Newborn ; Humans ; Animals ; Mice ; Infant, Premature ; Lateral Ventricles ; Stem Cell Niche |
| مستخلص: | Brain injury is highly associated with preterm birth. Complications of prematurity, including spontaneous or necrotizing enterocolitis (NEC)-associated intestinal perforations, are linked to lifelong neurologic impairment, yet the mechanisms are poorly understood. Early diagnosis of preterm brain injuries remains a significant challenge. Here, we identified subventricular zone echogenicity (SVE) on cranial ultrasound in preterm infants following intestinal perforations. The development of SVE was significantly associated with motor impairment at 2 years. SVE was replicated in a neonatal mouse model of intestinal perforation. Examination of the murine echogenic subventricular zone (SVZ) revealed NLRP3-inflammasome assembly in multiciliated FoxJ1 + ependymal cells and a loss of the ependymal border in this postnatal stem cell niche. These data suggest a mechanism of preterm brain injury localized to the SVZ that has not been adequately considered. Ultrasound detection of SVE may serve as an early biomarker for neurodevelopmental impairment after inflammatory disease in preterm infants. Competing Interests: Declaration of interests E.J.B. and S.G.G. are scientific cofounders at Tellus Therapeutics—a startup company developing therapies for neonatal brain injury. There is no intellectual property associated with this manuscript. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| References: | Science. 2006 Feb 3;311(5761):629-32. (PMID: 16410488) Nature. 2012 Jan 18;481(7381):278-86. (PMID: 22258606) Cell Rep. 2016 Jul 12;16(2):571-582. (PMID: 27346360) J Child Neurol. 2010 Jul;25(7):809-14. (PMID: 20595696) Prog Neurobiol. 2013 Jul-Aug;106-107:1-16. (PMID: 23583307) J Neurosci Res. 1997 Apr 15;48(2):83-94. (PMID: 9130137) Development. 2009 Dec;136(23):4021-31. (PMID: 19906869) Neuroimage. 2021 Dec 15;245:118688. (PMID: 34758381) Neuron. 2011 May 26;70(4):674-86. (PMID: 21609824) Acta Paediatr. 2000 Sep;89(9):1111-4. (PMID: 11071094) J Pediatr. 2014 Feb;164(2):410-2.e1. (PMID: 24210927) J Pediatr. 2004 Nov;145(5):593-9. (PMID: 15520756) Neuron. 2011 Jul 14;71(1):61-75. (PMID: 21745638) Pediatrics. 2005 Mar;115(3):696-703. (PMID: 15741374) Pediatr Radiol. 1998 May;28(5):297-302. (PMID: 9569264) Acta Neuropathol. 2017 Sep;134(3):331-349. (PMID: 28534077) Pediatr Res. 2022 Apr;91(5):1182-1195. (PMID: 34103675) J Child Neurol. 2009 Jan;24(1):36-44. (PMID: 19168817) Ann Surg. 2021 Oct 1;274(4):e370-e380. (PMID: 34506326) BMC Dev Biol. 2007 Apr 17;7:33. (PMID: 17439658) Nat Genet. 2008 Dec;40(12):1445-53. (PMID: 19011630) Cell Mol Immunol. 2021 May;18(5):1106-1121. (PMID: 33785842) Neuroscience. 2006 May 12;139(2):555-64. (PMID: 16500031) Front Immunol. 2021 Apr 21;12:650709. (PMID: 33968047) Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13211-6. (PMID: 12235363) J Neuroinflammation. 2019 May 10;16(1):97. (PMID: 31077225) Pediatrics. 2014 Aug;134(2):e444-53. (PMID: 25070300) Trends Neurosci. 2021 Nov;44(11):864-875. (PMID: 34312005) Nat Neurosci. 2010 Jun;13(6):690-9. (PMID: 20436478) J Neurosci. 2006 Jul 26;26(30):7907-18. (PMID: 16870736) N Engl J Med. 2006 Aug 17;355(7):685-94. (PMID: 16914704) Shock. 2007 Dec;28(6):675-683. (PMID: 17621256) Nature. 2010 Mar 25;464(7288):554-561. (PMID: 20154730) Arch Dis Child Fetal Neonatal Ed. 2021 Sep;106(5):467-473. (PMID: 33478957) Stem Cell Reports. 2015 Oct 13;5(4):461-70. (PMID: 26411905) J Neuropathol Exp Neurol. 2009 Sep;68(9):1006-20. (PMID: 19680142) J Neuroinflammation. 2018 Jun 9;15(1):180. (PMID: 29885660) J Neuroinflammation. 2016 Aug 22;13(1):190. (PMID: 27550173) Nat Commun. 2018 Apr 25;9(1):1655. (PMID: 29695808) Cell. 2023 Feb 16;186(4):764-785.e21. (PMID: 36803604) Semin Ultrasound CT MR. 2010 Apr;31(2):71-85. (PMID: 20304317) J Neurosci. 2014 Oct 15;34(42):14128-46. (PMID: 25319708) Neuron. 1993 Feb;10(2):201-12. (PMID: 8439409) PLoS One. 2009 Dec 02;4(12):e8122. (PMID: 19956583) Cell Res. 2015 Dec;25(12):1285-98. (PMID: 26611636) Neonatology. 2016;110(2):148-54. (PMID: 27105356) J Neuroinflammation. 2021 Mar 6;18(1):66. (PMID: 33676524) J Perinatol. 2014 Jan;34(1):64-70. (PMID: 24135709) Cell. 2020 Aug 6;182(3):594-608.e11. (PMID: 32679030) N Engl J Med. 2017 Feb 16;376(7):617-628. (PMID: 28199816) Nature. 2018 Mar 15;555(7696):377-381. (PMID: 29513649) Dev Med Child Neurol. 2011 Nov;53(11):1000-6. (PMID: 22014319) J Immunol. 2009 Jul 15;183(2):787-91. (PMID: 19570822) Ann Surg. 2005 Jun;241(6):984-9; discussion 989-94. (PMID: 15912048) Cell Stem Cell. 2008 Sep 11;3(3):265-78. (PMID: 18786414) Nature. 2013 May 16;497(7449):369-73. (PMID: 23615612) Cell Stem Cell. 2023 Aug 3;30(8):1054-1071.e8. (PMID: 37541211) Nat Rev Gastroenterol Hepatol. 2023 Jun;20(6):366-387. (PMID: 36781958) Blood. 2008 Sep 1;112(5):1750-8. (PMID: 18591384) Sci Transl Med. 2021 Jan 6;13(575):. (PMID: 33408187) Pediatrics. 2011 Jan;127(1):62-70. (PMID: 21187312) Sci Transl Med. 2018 Dec 12;10(471):. (PMID: 30541786) Cell. 1999 Jun 11;97(6):703-16. (PMID: 10380923) Science. 2016 Oct 7;354(6308):. (PMID: 27846470) Dev Cell. 2020 Dec 7;55(5):617-628.e6. (PMID: 33038331) JAMA. 2022 Jan 18;327(3):248-263. (PMID: 35040888) J Pediatr. 2008 Aug;153(2):170-5, 175.e1. (PMID: 18534228) |
| معلومات مُعتمدة: | R01 NS120417 United States NS NINDS NIH HHS; T32 AI007062 United States AI NIAID NIH HHS; R01 NS114578 United States NS NINDS NIH HHS; R01 AI160737 United States AI NIAID NIH HHS; T32 HD094671 United States HD NICHD NIH HHS |
| فهرسة مساهمة: | Keywords: cerebral palsy; cranial ultrasound; ependymal; inflammasome; intestinal perforation; necrotizing enterocolitis; neonatal brain injury; neural stem cell; neurodevelopmental outcome; niche; preterm infant; subventricular zone; white matter injury |
| تواريخ الأحداث: | Date Created: 20240327 Date Completed: 20240408 Latest Revision: 20240626 |
| رمز التحديث: | 20240626 |
| مُعرف محوري في PubMed: | PMC11129818 |
| DOI: | 10.1016/j.stem.2024.03.001 |
| PMID: | 38537631 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-9777 |
|---|---|
| DOI: | 10.1016/j.stem.2024.03.001 |