دورية أكاديمية
Host metabolomic responses in recurrent P. vivax malaria.
| العنوان: | Host metabolomic responses in recurrent P. vivax malaria. |
|---|---|
| المؤلفون: | Yakubu MN; State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil.; Department of Microbiology, Federal University Wukari, Wukari, Taraba State, Nigeria., Mwangi VI; State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil., Netto RLA; State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil., Alecrim MGC; State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil., Alves JRS; Institute of Biology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva (LDT-LJS), Department of Genetics, Evolution, Microbiology and Immunology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., Almeida ACG; State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil.; Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil.; Postgraduate Program in Sciences Applied to Hematology, PPGHUEA/HEMOAM), Manaus, Amazonas, Brazil., Santos GF; Chromatography and Mass Spectrometry Laboratory, Institute of Chemistry, Federal University of Goiás, Goiânia, Goiás, Brazil., Lima GS; Chromatography and Mass Spectrometry Laboratory, Institute of Chemistry, Federal University of Goiás, Goiânia, Goiás, Brazil., Machado LS; Chromatography and Mass Spectrometry Laboratory, Institute of Chemistry, Federal University of Goiás, Goiânia, Goiás, Brazil., Koolen HHF; State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil.; Metabolomics and Mass Spectrometry Research Group, State University of Amazonas, Manaus, Amazonas, Brazil., Guimarães TP; Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, Goiás, Brazil., Chaves AR; Chromatography and Mass Spectrometry Laboratory, Institute of Chemistry, Federal University of Goiás, Goiânia, Goiás, Brazil., Vaz BG; Chromatography and Mass Spectrometry Laboratory, Institute of Chemistry, Federal University of Goiás, Goiânia, Goiás, Brazil., Monteiro WM; State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil., Costa FTM; Institute of Biology, Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva (LDT-LJS), Department of Genetics, Evolution, Microbiology and Immunology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil., Lacerda MVG; State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil.; Leônidas & Maria Deane Institute/Oswaldo Cruz Fundation (ILMD/Fiocruz Amazônia), Manaus, Brazil., Gardinassi LG; University of São Paulo, Ribeirão Preto School of Nursing, Department of Maternal and Child Nursing and Public Health, Ribeirão Preto, Brazil. gardinassi@eerp.usp.br., de Melo GC; State University of Amazonas (UEA), Manaus, Amazonas, Brazil/Tropical Medicine Foundation-Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, Brazil. cardosogisely@gmail.com.; Postgraduate Program in Sciences Applied to Hematology, PPGHUEA/HEMOAM), Manaus, Amazonas, Brazil. cardosogisely@gmail.com. |
| المصدر: | Scientific reports [Sci Rep] 2024 Mar 27; Vol. 14 (1), pp. 7249. Date of Electronic Publication: 2024 Mar 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Malaria, Vivax*/parasitology , Malaria*/parasitology , Antimalarials*/therapeutic use, Humans ; Metabolomics ; Metabolome |
| مستخلص: | Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax-infected patients were subjected to LC-MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax. (© 2024. The Author(s).) |
| References: | PLoS Comput Biol. 2013;9(7):e1003123. (PMID: 23861661) Int J Mol Sci. 2012 Dec 03;13(12):16346-72. (PMID: 23208374) Sci Rep. 2021 Apr 12;11(1):7922. (PMID: 33846380) Front Cell Infect Microbiol. 2023 Jan 13;12:1058926. (PMID: 36710962) JCI Insight. 2019 May 2;4(9):. (PMID: 31045574) PLoS Pathog. 2020 Nov 12;16(11):e1008930. (PMID: 33180883) Nat Biotechnol. 2007 Dec;25(12):1383-9. (PMID: 18066032) Science. 2022 Jun 3;376(6597):1074-1079. (PMID: 35653481) Trends Parasitol. 2010 Mar;26(3):145-51. (PMID: 20133198) PLoS One. 2020 Nov 12;15(11):e0242372. (PMID: 33180822) J Infect Dis. 2015 Sep 15;212(6):999-1008. (PMID: 25748326) PLoS Pathog. 2015 Mar 12;11(3):e1004655. (PMID: 25764173) Pharmacol Res. 2021 May;167:105570. (PMID: 33766628) Brain Res. 2012 Oct 10;1478:74-82. (PMID: 22967964) Nat Commun. 2019 Dec 20;10(1):5811. (PMID: 31862874) Metabolomics. 2007 Sep;3(3):211-221. (PMID: 24039616) mSystems. 2023 Dec 21;8(6):e0072623. (PMID: 37874139) J Chromatogr B Biomed Sci Appl. 1997 Nov 7;701(1):115-9. (PMID: 9389345) Nat Med. 2020 Dec;26(12):1929-1940. (PMID: 33106664) PLoS One. 2017 Apr 20;12(4):e0175686. (PMID: 28426698) J Anal Sci Technol. 2015;6(1):3. (PMID: 26269748) Malar J. 2020 Feb 27;19(1):94. (PMID: 32103749) Biomed Res Int. 2014;2014:108516. (PMID: 24524072) Front Cell Infect Microbiol. 2018 Feb 08;8:34. (PMID: 29473024) FEBS Lett. 1988 May 23;232(2):341-6. (PMID: 3378625) Malar J. 2017 May 30;16(1):229. (PMID: 28558710) Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13075-80. (PMID: 26438846) Cell. 2017 Dec 14;171(7):1532-1544.e15. (PMID: 29129376) Arterioscler Thromb Vasc Biol. 2011 May;31(5):986-1000. (PMID: 21508345) Malar J. 2012 Oct 08;11:337. (PMID: 23043460) PLoS Pathog. 2015 Mar 12;11(3):e1004667. (PMID: 25764397) Immunol Lett. 2017 Dec;192:88-96. (PMID: 28864335) Metabolites. 2022 Dec 06;12(12):. (PMID: 36557262) J Infect Dis. 2019 Jan 7;219(2):315-322. (PMID: 30102351) Mol Biochem Parasitol. 2003 Nov;132(1):55-8. (PMID: 14563537) Public Health Genomics. 2013;16(1-2):37-43. (PMID: 23548716) Microbiol Spectr. 2023 Feb 28;:e0219422. (PMID: 36852984) Evid Based Complement Alternat Med. 2020 Feb 12;2020:8749083. (PMID: 32104196) Malar J. 2015 Dec 21;14:513. (PMID: 26691993) J Infect Dis. 2006 May 15;193(10):1384-93. (PMID: 16619186) Acc Chem Res. 2012 Apr 17;45(4):588-97. (PMID: 22077696) Front Cell Infect Microbiol. 2021 Nov 30;11:768182. (PMID: 34917519) Trends Pharmacol Sci. 2021 Jan;42(1):60-73. (PMID: 33256987) J Parasitol Res. 2011;2011:901854. (PMID: 21772982) Antimicrob Agents Chemother. 2016 Jul 22;60(8):4610-9. (PMID: 27185794) Clin Invest Med. 2009 Feb 01;32(1):E13-9. (PMID: 19178874) Curr Opin Toxicol. 2018 Feb;7:81-86. (PMID: 29862377) Elife. 2022 Dec 28;11:. (PMID: 36576255) Antimicrob Agents Chemother. 2021 Mar 18;65(4):. (PMID: 33495219) Redox Biol. 2018 Jul;17:158-170. (PMID: 29698924) PLoS One. 2017 Aug 16;12(8):e0182819. (PMID: 28813452) J R Soc Interface. 2008 Dec 6;5 Suppl 3:S191-8. (PMID: 18782724) Trop Med Infect Dis. 2022 Sep 24;7(10):. (PMID: 36288004) Mediators Inflamm. 2012;2012:595694. (PMID: 22577251) Int J Med Microbiol. 2017 Dec;307(8):533-541. (PMID: 28927849) Malar J. 2014 Apr 15;13:144. (PMID: 24731298) Lancet Infect Dis. 2009 Sep;9(9):555-66. (PMID: 19695492) Malar J. 2010 Apr 23;9:110. (PMID: 20412601) Parasit Vectors. 2018 Mar 20;11(1):194. (PMID: 29558985) J Transl Med. 2018 Oct 4;16(1):272. (PMID: 30286756) Sci Rep. 2019 Feb 27;9(1):2875. (PMID: 30814599) J Chromatogr B Biomed Sci Appl. 1999 Aug 6;731(1):105-10. (PMID: 10491995) Sci Rep. 2019 Apr 29;9(1):6602. (PMID: 31036854) Biomed Res Int. 2014;2014:852645. (PMID: 24804253) PLoS Negl Trop Dis. 2015 Mar 17;9(3):e0003595. (PMID: 25780913) PLoS One. 2014 Apr 18;9(4):e94061. (PMID: 24747974) Mem Inst Oswaldo Cruz. 2014 Aug;109(5):589-97. (PMID: 25185001) Nat Commun. 2023 Jul 11;14(1):4113. (PMID: 37433854) PLoS One. 2014 Aug 26;9(8):e105922. (PMID: 25157811) J Immunol. 2010 Jul 15;185(2):1196-204. (PMID: 20562262) Malar J. 2011 Dec 23;10:384. (PMID: 22196439) Front Microbiol. 2021 Jan 11;11:626183. (PMID: 33505389) |
| المشرفين على المادة: | 0 (Antimalarials) |
| تواريخ الأحداث: | Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240330 |
| رمز التحديث: | 20240330 |
| مُعرف محوري في PubMed: | PMC10973444 |
| DOI: | 10.1038/s41598-024-54231-5 |
| PMID: | 38538661 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
|---|---|
| DOI: | 10.1038/s41598-024-54231-5 |