دورية أكاديمية
Intersections of Fibrodysplasia Ossificans Progressiva and Traumatic Heterotopic Ossification.
العنوان: | Intersections of Fibrodysplasia Ossificans Progressiva and Traumatic Heterotopic Ossification. |
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المؤلفون: | Juan C; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Bancroft AC; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Baylor College of Medicine, Houston, TX 77030, USA., Choi JH; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Nunez JH; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Pagani CA; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Lin YS; Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Hsiao EC; Division of Endocrinology and Metabolism, Department of Medicine, the Institute for Human Genetics, and the Program in Craniofacial Biology, University of California San Francisco Medical Center, San Francisco, CA 94143, USA., Levi B; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. |
المصدر: | Biomolecules [Biomolecules] 2024 Mar 14; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 14. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, 2011- |
مواضيع طبية MeSH: | Myositis Ossificans*/diagnosis , Myositis Ossificans*/genetics , Myositis Ossificans*/complications , Ossification, Heterotopic*/etiology , Ossification, Heterotopic*/metabolism , Ossification, Heterotopic*/pathology, Humans ; Osteogenesis ; Bone and Bones/metabolism |
مستخلص: | Heterotopic ossification (HO) is a debilitating pathology where ectopic bone develops in areas of soft tissue. HO can develop as a consequence of traumatic insult or as a result of dysregulated osteogenic signaling, as in the case of the orphan disease fibrodysplasia ossificans progressiva (FOP). Traumatic HO (tHO) formation is mediated by the complex interplay of signaling between progenitor, inflammatory, and nerve cells, among others, making it a challenging process to understand. Research into the pathogenesis of genetically mediated HO (gHO) in FOP has established a pathway involving uninhibited activin-like kinase 2 receptor (ALK2) signaling that leads to downstream osteogenesis. Current methods of diagnosis and treatment lag behind pre-mature HO detection and progressive HO accumulation, resulting in irreversible decreases in range of motion and chronic pain for patients. As such, it is necessary to draw on advancements made in the study of tHO and gHO to better diagnose, comprehend, prevent, and treat both. |
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معلومات مُعتمدة: | R01 AR079171 and R01AR079171-07S1 United States NH NIH HHS |
فهرسة مساهمة: | Keywords: ACVR2; ALK2; ectopic bone; fibrodysplasia ossificans progressiva; heterotopic ossification; trauma |
تواريخ الأحداث: | Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240330 |
رمز التحديث: | 20240330 |
مُعرف محوري في PubMed: | PMC10968060 |
DOI: | 10.3390/biom14030349 |
PMID: | 38540768 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2218-273X |
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DOI: | 10.3390/biom14030349 |