دورية أكاديمية
أعرض في EDS

Intersections of Fibrodysplasia Ossificans Progressiva and Traumatic Heterotopic Ossification.

التفاصيل البيبلوغرافية
العنوان: Intersections of Fibrodysplasia Ossificans Progressiva and Traumatic Heterotopic Ossification.
المؤلفون: Juan C; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Bancroft AC; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Baylor College of Medicine, Houston, TX 77030, USA., Choi JH; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Nunez JH; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Pagani CA; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Lin YS; Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Hsiao EC; Division of Endocrinology and Metabolism, Department of Medicine, the Institute for Human Genetics, and the Program in Craniofacial Biology, University of California San Francisco Medical Center, San Francisco, CA 94143, USA., Levi B; Center for Organogenesis, Regeneration, and Trauma, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
المصدر: Biomolecules [Biomolecules] 2024 Mar 14; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 14.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, 2011-
مواضيع طبية MeSH: Myositis Ossificans*/diagnosis , Myositis Ossificans*/genetics , Myositis Ossificans*/complications , Ossification, Heterotopic*/etiology , Ossification, Heterotopic*/metabolism , Ossification, Heterotopic*/pathology, Humans ; Osteogenesis ; Bone and Bones/metabolism
مستخلص: Heterotopic ossification (HO) is a debilitating pathology where ectopic bone develops in areas of soft tissue. HO can develop as a consequence of traumatic insult or as a result of dysregulated osteogenic signaling, as in the case of the orphan disease fibrodysplasia ossificans progressiva (FOP). Traumatic HO (tHO) formation is mediated by the complex interplay of signaling between progenitor, inflammatory, and nerve cells, among others, making it a challenging process to understand. Research into the pathogenesis of genetically mediated HO (gHO) in FOP has established a pathway involving uninhibited activin-like kinase 2 receptor (ALK2) signaling that leads to downstream osteogenesis. Current methods of diagnosis and treatment lag behind pre-mature HO detection and progressive HO accumulation, resulting in irreversible decreases in range of motion and chronic pain for patients. As such, it is necessary to draw on advancements made in the study of tHO and gHO to better diagnose, comprehend, prevent, and treat both.
References: Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47. (PMID: 26721400)
Genes Dev. 2006 Mar 15;20(6):666-74. (PMID: 16543220)
Nat Rev Immunol. 2006 Feb;6(2):93-106. (PMID: 16491134)
Mol Ther. 2002 Oct;6(4):464-70. (PMID: 12377187)
Cell Tissue Res. 2016 Oct;366(1):101-11. (PMID: 27083447)
Nat Cell Biol. 2010 Feb;12(2):153-63. (PMID: 20081841)
J Bone Miner Res. 2022 Mar;37(3):531-546. (PMID: 34841579)
Sci Rep. 2023 Nov 18;13(1):20210. (PMID: 37980449)
J Bone Miner Res. 2016 Sep;31(9):1652-65. (PMID: 27027798)
J Cell Biol. 1994 Dec;127(6 Pt 1):1755-66. (PMID: 7798324)
Postgrad Med J. 2014 Nov;90(1069):643-7. (PMID: 25335795)
J Biol Chem. 2004 Dec 3;279(49):50773-80. (PMID: 15383550)
Hand Clin. 2017 May;33(2):363-373. (PMID: 28363301)
J Cell Biol. 1996 Jan;132(1-2):195-210. (PMID: 8567723)
J Arthroplasty. 1995 Aug;10(4):413-9. (PMID: 8522997)
Nature. 1999 May 20;399(6733):271-5. (PMID: 10353251)
Best Pract Res Clin Rheumatol. 2008 Mar;22(1):191-205. (PMID: 18328989)
Cell Rep. 2016 Sep 6;16(10):2723-2735. (PMID: 27568565)
Nat Med. 2011 Apr;17(4):454-60. (PMID: 21460849)
Cells. 2021 Apr 19;10(4):. (PMID: 33921676)
Physiol Rev. 2019 Jan 1;99(1):739-780. (PMID: 30540228)
Nat Med. 2010 Dec;16(12):1400-6. (PMID: 21102460)
Orphanet J Rare Dis. 2023 May 10;18(1):111. (PMID: 37165433)
Bone. 2020 Sep;138:115473. (PMID: 32553795)
PLoS One. 2009;4(4):e5275. (PMID: 19357790)
Int J Radiat Oncol Biol Phys. 1987 Mar;13(3):365-9. (PMID: 3104246)
Stem Cells. 2019 Dec;37(12):1595-1605. (PMID: 31461199)
JBMR Plus. 2019 Feb 27;3(4):e10172. (PMID: 31044187)
Bone Res. 2019 Dec 10;7:36. (PMID: 31840004)
J Orthop Translat. 2019 Jul 05;18:142-153. (PMID: 31508317)
J Orthop Res. 2004 May;22(3):526-34. (PMID: 15099631)
Cold Spring Harb Perspect Biol. 2016 Jun 01;8(6):. (PMID: 27252362)
J Bone Joint Surg Am. 1993 Feb;75(2):220-30. (PMID: 7678595)
Bone. 2018 Apr;109:104-110. (PMID: 29033382)
Hum Pathol. 2001 Aug;32(8):842-8. (PMID: 11521229)
J Biol Chem. 1996 Dec 13;271(50):32253-9. (PMID: 8943284)
JCI Insight. 2022 Oct 24;7(20):. (PMID: 36099022)
J Musculoskelet Neuronal Interact. 2010 Jun;10(2):159-65. (PMID: 20516633)
Mech Dev. 2008 Mar-Apr;125(3-4):257-69. (PMID: 18164186)
Bone. 2018 Apr;109:210-217. (PMID: 28629737)
Stem Cells. 2014 May;32(5):1289-300. (PMID: 24449086)
Stem Cells. 2008 Aug;26(8):2042-51. (PMID: 18499897)
Bone. 2013 Sep;56(1):119-26. (PMID: 23727270)
JBMR Plus. 2019 Mar 01;3(8):e10181. (PMID: 31485551)
PLoS Genet. 2006 Dec;2(12):e216. (PMID: 17194222)
Bone. 2018 Apr;109:259-266. (PMID: 28851540)
Clin Orthop Relat Res. 2013 Sep;471(9):2776-82. (PMID: 23440617)
Spinal Cord. 2021 Jun;59(6):635-641. (PMID: 32873893)
J Bone Miner Res. 2023 Mar;38(3):381-394. (PMID: 36583535)
Cell Res. 2009 Jan;19(1):8-20. (PMID: 19114991)
Nat Rev Mol Cell Biol. 2011 Dec 21;13(2):127-33. (PMID: 22186952)
Nat Commun. 2018 Feb 7;9(1):551. (PMID: 29416028)
Pediatr Rheumatol Online J. 2019 Dec 21;17(1):84. (PMID: 31864380)
Nat Rev Mol Cell Biol. 2007 Dec;8(12):970-82. (PMID: 18000526)
J Orthop Trauma. 2012 Nov;26(11):e204-13. (PMID: 22588530)
Cell Death Dis. 2021 Jul 22;12(8):729. (PMID: 34294700)
Front Med (Lausanne). 2022 Mar 22;9:852678. (PMID: 35391888)
Signal Transduct Target Ther. 2023 Jul 5;8(1):260. (PMID: 37402714)
J Biol Chem. 2010 Sep 17;285(38):29588-98. (PMID: 20628059)
Nat Med. 2023 Oct;29(10):2615-2624. (PMID: 37770652)
J Clin Pharmacol. 2020 Nov;60(11):1424-1431. (PMID: 32557665)
J Med Case Rep. 2020 Jul 8;14(1):92. (PMID: 32635936)
Bone. 2021 Dec;153:116129. (PMID: 34311122)
J Biol Chem. 2008 Oct 24;283(43):29119-25. (PMID: 18703512)
Cells. 2019 Oct 31;8(11):. (PMID: 31683698)
J Cell Physiol. 1988 Mar;134(3):337-46. (PMID: 3162457)
J Hand Ther. 2006 Apr-Jun;19(2):255-66. (PMID: 16713872)
Front Biosci. 2004 Jan 01;9:619-31. (PMID: 14766396)
J Bone Miner Res. 1999 Oct;14(10):1734-41. (PMID: 10491221)
Arch Pathol Lab Med. 2004 Mar;128(3):321-3. (PMID: 14987154)
JBMR Plus. 2017 Jul 05;2(1):55-58. (PMID: 30283890)
Orphanet J Rare Dis. 2021 Aug 5;16(1):350. (PMID: 34353327)
Nat Med. 2014 Jun;20(6):670-5. (PMID: 24793237)
Sci Transl Med. 2021 Jun 23;13(599):. (PMID: 34162750)
J Bone Miner Res. 2015 Jun;30(6):1090-102. (PMID: 25487241)
Organogenesis. 2018 Jan 2;14(1):36-45. (PMID: 29913119)
Spinal Cord. 2010 Jul;48(7):511. (PMID: 20596029)
Injury. 2014 Oct;45(10):1604-10. (PMID: 24917211)
Acta Orthop Belg. 2020 Sep;86(3):369-377. (PMID: 33581019)
Nat Med. 2009 Jul;15(7):757-65. (PMID: 19584867)
Int J Biochem Cell Biol. 2004 Aug;36(8):1374-9. (PMID: 15147715)
Biochem Biophys Res Commun. 2010 Oct 8;401(1):20-5. (PMID: 20816936)
Cytokine Growth Factor Rev. 2016 Feb;27:93-104. (PMID: 26776312)
Cell. 1996 Aug 9;86(3):435-44. (PMID: 8756725)
J Bone Miner Res. 2015 Apr;30(4):733-41. (PMID: 25413979)
Biochem Biophys Res Commun. 1996 Mar 18;220(2):366-71. (PMID: 8645311)
Nat Cell Biol. 2010 Feb;12(2):143-52. (PMID: 20081842)
Cell Tissue Res. 2014 Feb;355(2):463-70. (PMID: 24253465)
Bone. 2020 Oct;139:115517. (PMID: 32622875)
N Engl J Med. 1996 Aug 22;335(8):555-61. (PMID: 8678932)
J Cell Sci. 1999 Oct;112 ( Pt 20):3519-27. (PMID: 10504300)
NPJ Regen Med. 2022 Jan 14;7(1):5. (PMID: 35031614)
Pharm World Sci. 2003 Aug;25(4):138-45. (PMID: 12964491)
J Cell Sci. 2013 Dec 15;126(Pt 24):5704-13. (PMID: 24144697)
J Bone Joint Surg Am. 2009 Mar 1;91(3):652-63. (PMID: 19255227)
Stem Cells. 2009 Jan;27(1):150-6. (PMID: 18832590)
J Cell Biol. 1991 May;113(3):681-7. (PMID: 1849907)
Adv Wound Care (New Rochelle). 2013 Jul;2(6):306-316. (PMID: 24527352)
J Bone Miner Res. 2022 Oct;37(10):1891-1902. (PMID: 35854638)
EMBO J. 2001 May 1;20(9):2254-72. (PMID: 11331591)
J Cell Biol. 2011 Nov 28;195(5):709-20. (PMID: 22123859)
J Bone Joint Surg Am. 2003 Dec;85(12):2332-42. (PMID: 14668502)
J Biol Chem. 2012 Jan 6;287(2):905-15. (PMID: 22102412)
EMBO J. 1997 Jul 1;16(13):3866-76. (PMID: 9233797)
Clin Orthop Relat Res. 1997 Jul;(340):267-75. (PMID: 9224265)
J Am Acad Orthop Surg. 2009 Nov;17(11):689-97. (PMID: 19880679)
J Clin Invest. 2017 Sep 1;127(9):3339-3352. (PMID: 28758906)
J Bone Miner Res. 2016 Mar;31(3):650-6. (PMID: 27025942)
J Bone Miner Metab. 2003;21(6):337-43. (PMID: 14586789)
Sci Transl Med. 2016 Nov 23;8(366):366ra163. (PMID: 27881824)
J Orthop Surg Res. 2017 May 4;12(1):69. (PMID: 28472996)
Am J Pathol. 2017 Nov;187(11):2536-2545. (PMID: 29029772)
Pediatr Rheumatol Online J. 2023 Aug 29;21(1):92. (PMID: 37644581)
Nat Genet. 2006 May;38(5):525-7. (PMID: 16642017)
Bone. 2002 Jan;30(1):26-31. (PMID: 11792561)
J Bone Miner Res. 2011 Jun;26(6):1166-77. (PMID: 21611960)
Front Cell Dev Biol. 2020 Sep 25;8:570605. (PMID: 33102476)
Elife. 2021 Nov 10;10:. (PMID: 34755602)
Nat Commun. 2021 Aug 16;12(1):4939. (PMID: 34400627)
Cancer. 1981 Sep 1;48(5):1256-61. (PMID: 6791807)
J Autoimmun. 2019 Nov;104:102314. (PMID: 31416681)
Calcif Tissue Int. 2021 Feb;108(2):196-206. (PMID: 33044630)
Front Cell Neurosci. 2022 Feb 09;16:842090. (PMID: 35221928)
J Am Acad Orthop Surg. 2002 Nov-Dec;10(6):409-16. (PMID: 12470043)
J Cell Biochem. 2011 Jun;112(6):1651-60. (PMID: 21344492)
J Bone Miner Res. 2018 Feb;33(2):269-282. (PMID: 28986986)
J Neurotrauma. 2007 Nov;24(11):1675-86. (PMID: 18001198)
Cureus. 2022 Apr 30;14(4):e24620. (PMID: 35664416)
Stem Cells. 2019 Jun;37(6):766-778. (PMID: 30786091)
Ann R Coll Surg Engl. 2008 Jul;90(5):W12-4. (PMID: 18634722)
Spinal Cord. 2015 May;53(5):340-4. (PMID: 25687517)
Development. 1997 Jul;124(13):2659-70. (PMID: 9217007)
J Bone Miner Res. 2008 Mar;23(3):305-13. (PMID: 17967130)
Bone Res. 2022 Jan 7;10(1):4. (PMID: 34996891)
Pain. 2023 Jan 1;164(1):43-58. (PMID: 35442931)
Bone Joint Res. 2013 Mar 01;2(3):51-7. (PMID: 23610702)
Orphanet J Rare Dis. 2022 Sep 21;17(1):364. (PMID: 36131296)
Arch Phys Med Rehabil. 2022 May;103(5):998-1012.e14. (PMID: 34425089)
Nat Med. 2007 Oct;13(10):1219-27. (PMID: 17828274)
Int J Mol Med. 2019 Jan;43(1):37-46. (PMID: 30365093)
J Cell Biochem. 2011 Oct;112(10):2748-58. (PMID: 21678472)
Mol Endocrinol. 2003 Dec;17(12):2404-17. (PMID: 14551263)
J Bone Joint Surg Am. 1985 Oct;67(8):1261-9. (PMID: 3932363)
Mol Ther. 2011 Aug;19(8):1426-32. (PMID: 21629226)
Front Immunol. 2019 Jul 19;10:1640. (PMID: 31396210)
Cell Rep. 2019 May 14;27(7):2029-2035.e5. (PMID: 31091443)
Sci Transl Med. 2015 Sep 2;7(303):303ra137. (PMID: 26333933)
Cell Res. 2009 Jan;19(1):128-39. (PMID: 19114990)
J Cell Mol Med. 2009 Aug;13(8B):2448-2464. (PMID: 19175684)
Cytometry B Clin Cytom. 2018 Jul;94(4):613-622. (PMID: 28985649)
Dev Dyn. 2000 Apr;217(4):401-14. (PMID: 10767084)
J Bone Miner Res. 2022 Nov;37(11):2077-2093. (PMID: 35637634)
Nat Genet. 1995 Dec;11(4):415-21. (PMID: 7493022)
Bone. 2013 Jul;55(1):93-101. (PMID: 23571050)
Stem Cells Dev. 2021 Jan 15;30(2):91-105. (PMID: 33256557)
Clin Exp Pharmacol Physiol. 2022 Aug;49(8):881-892. (PMID: 35638441)
J Am Acad Orthop Surg. 2006;14(10 Spec No.):S191-7. (PMID: 17003198)
J Clin Invest. 2009 Nov;119(11):3462-72. (PMID: 19855136)
J Biol Chem. 2007 Jul 13;282(28):20534-43. (PMID: 17502379)
Dev Biol. 2007 Oct 15;310(2):304-16. (PMID: 17822689)
EMBO J. 2009 Jul 22;28(14):2028-41. (PMID: 19536134)
Jt Dis Relat Surg. 2020;31(2):386-389. (PMID: 32584742)
J Bone Joint Surg Am. 2007 Feb;89(2):347-57. (PMID: 17272450)
Clin Orthop Relat Res. 2014 Sep;472(9):2845-54. (PMID: 24879568)
J Bone Joint Surg Am. 2015 Jul 1;97(13):1101-11. (PMID: 26135077)
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):770-4. (PMID: 8421714)
JCI Insight. 2018 Nov 15;3(22):. (PMID: 30429363)
J Cell Physiol. 2008 Oct;217(1):228-41. (PMID: 18506848)
Inflammation. 2023 Feb;46(1):202-216. (PMID: 35986177)
Int J Stem Cells. 2020 Mar 30;13(1):1-12. (PMID: 31887851)
Nat Commun. 2018 Feb 02;9(1):471. (PMID: 29396429)
Front Neurol. 2018 Sep 13;9:771. (PMID: 30271377)
Sci Signal. 2021 Feb 09;14(669):. (PMID: 33563697)
Bone Res. 2022 Jun 1;10(1):43. (PMID: 35641477)
Bone. 2017 Jan;94:1-9. (PMID: 27725318)
Singapore Med J. 2014 Aug;55(8):e119-22. (PMID: 25189310)
EMBO J. 2004 Feb 11;23(3):552-63. (PMID: 14749725)
Stem Cells Dev. 2009 May;18(4):545-59. (PMID: 18616389)
Mol Cell Biol. 2002 Oct;22(20):7004-14. (PMID: 12242281)
Curr Osteoporos Rep. 2019 Dec;17(6):387-394. (PMID: 31721068)
J Biol Chem. 2000 Nov 24;275(47):36803-10. (PMID: 10969078)
Hum Mutat. 2009 Mar;30(3):379-90. (PMID: 19085907)
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15438-43. (PMID: 26621707)
Nat Rev Immunol. 2017 Nov;17(11):665-678. (PMID: 28804130)
J Bone Miner Res. 2018 Feb;33(2):365-366. (PMID: 29178621)
Scars Burn Heal. 2017 Mar 15;3:2059513117695659. (PMID: 29799559)
EMBO J. 2005 Jul 20;24(14):2543-55. (PMID: 15990875)
Development. 2011 Sep;138(17):3657-66. (PMID: 21828094)
J Bone Miner Res. 2006 Apr;21(4):637-46. (PMID: 16598384)
Biomedicines. 2021 Feb 05;9(2):. (PMID: 33562570)
Bone Res. 2023 Jul 21;11(1):39. (PMID: 37479686)
J Orthop Translat. 2017 Nov 14;12:16-25. (PMID: 29662775)
EMBO J. 2002 Jul 15;21(14):3749-59. (PMID: 12110587)
Stem Cells. 2017 Mar;35(3):705-710. (PMID: 27862618)
JCI Insight. 2022 Jul 22;7(14):. (PMID: 35866484)
J Cell Physiol. 2012 Jun;227(6):2677-85. (PMID: 21898406)
Nat Commun. 2020 Feb 5;11(1):722. (PMID: 32024825)
Ann Surg. 2023 Dec 1;278(6):e1289-e1298. (PMID: 37325925)
J Bone Miner Res. 2012 Aug;27(8):1746-56. (PMID: 22508565)
Paraplegia. 1990 Sep;28(7):441-7. (PMID: 2123534)
J Bone Miner Res. 2022 Jan;37(1):95-107. (PMID: 34633114)
JCI Insight. 2021 Apr 22;6(8):. (PMID: 33705358)
J Bone Miner Res. 2012 May;27(5):1004-17. (PMID: 22307978)
J Oral Pathol Med. 1995 Mar;24(3):125-9. (PMID: 7776264)
Cells Tissues Organs. 2011;194(2-4):291-5. (PMID: 21525719)
Dev Dyn. 2007 Feb;236(2):512-7. (PMID: 17117439)
Orphanet J Rare Dis. 2020 May 24;15(1):122. (PMID: 32448372)
Dev Biol. 2015 Apr 15;400(2):202-9. (PMID: 25722188)
Neoplasia. 2004 Sep-Oct;6(5):603-10. (PMID: 15548370)
Mol Ther. 2017 Aug 2;25(8):1974-1987. (PMID: 28716575)
Mediators Inflamm. 2015;2015:204842. (PMID: 25873754)
Plast Reconstr Surg. 2005 Sep 15;116(4):50e-53e. (PMID: 16163071)
J Clin Invest. 2022 Jun 15;132(12):. (PMID: 35503416)
Radiol Oncol. 2019 Sep 24;53(3):275-284. (PMID: 31553710)
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5667-72. (PMID: 9159130)
Adv Sci (Weinh). 2023 May;10(15):e2207224. (PMID: 36970815)
Am J Pathol. 2014 Dec;184(12):3192-204. (PMID: 25285719)
Clin Orthop Relat Res. 1998 Jan;(346):19-25. (PMID: 9577406)
Am J Pathol. 2004 Oct;165(4):1107-15. (PMID: 15466378)
معلومات مُعتمدة: R01 AR079171 and R01AR079171-07S1 United States NH NIH HHS
فهرسة مساهمة: Keywords: ACVR2; ALK2; ectopic bone; fibrodysplasia ossificans progressiva; heterotopic ossification; trauma
تواريخ الأحداث: Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240330
رمز التحديث: 20240330
مُعرف محوري في PubMed: PMC10968060
DOI: 10.3390/biom14030349
PMID: 38540768
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-273X
DOI:10.3390/biom14030349