دورية أكاديمية
Beyond Quadruple Therapy and Current Therapeutic Strategies in Heart Failure with Reduced Ejection Fraction: Medical Therapies with Potential to Become Part of the Therapeutic Armamentarium.
العنوان: | Beyond Quadruple Therapy and Current Therapeutic Strategies in Heart Failure with Reduced Ejection Fraction: Medical Therapies with Potential to Become Part of the Therapeutic Armamentarium. |
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المؤلفون: | Kourek C; Medical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, Greece., Briasoulis A; Medical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, Greece., Papamichail A; Medical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, Greece., Xanthopoulos A; Department of Cardiology, University Hospital of Larissa, 41110 Larissa, Greece., Tsougos E; Department of Cardiology, Hygeia Hospital, 15123 Athens, Greece., Farmakis D; Attikon University Hospital, Medical School of Athens, National and Kapodistrian University of Athens, 12462 Athens, Greece., Paraskevaidis I; Medical School of Athens, National and Kapodistrian University of Athens, 15772 Athens, Greece. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2024 Mar 07; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 07. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Heart Failure*, Urea/*analogs & derivatives, Humans ; Stroke Volume ; Hydralazine/pharmacology ; Hydralazine/therapeutic use ; Isosorbide Dinitrate/pharmacology ; Isosorbide Dinitrate/therapeutic use ; Angiotensin Receptor Antagonists/pharmacology ; Multicenter Studies as Topic |
مستخلص: | Heart failure with reduced ejection fraction (HFrEF) is a complex clinical syndrome with significant morbidity and mortality and seems to be responsible for approximately 50% of heart failure cases and hospitalizations worldwide. First-line treatments of patients with HFrEF, according to the ESC and AHA guidelines, include β-blockers, angiotensin receptor/neprilysin inhibitors, sodium-glucose cotransporter 2 inhibitors, and mineralocorticoid receptor antagonists. This quadruple therapy should be initiated during hospital stay and uptitrated to maximum doses within 6 weeks after discharge according to large multicenter controlled trials. Quadruple therapy improves survival by approximately 8 years for a 55-year-old heart failure patient. Additional therapeutic strategies targeting other signaling pathways such as ivabradine, digoxin, and isosorbide dinitrate and hydralazine combination for African Americans, as well as adjunctive symptomatic therapies, seem to be necessary in the management of HFrEF. Although second-line medications have not achieved improvements in mortality, they seem to decrease heart failure hospitalizations. There are novel medical therapies including vericiguat, omecamtiv mecarbil, genetic and cellular therapies, and mitochondria-targeted therapies. Moreover, mitraclip for significant mitral valve regurgitation, ablation in specific atrial fibrillation cases, omecamtiv mecarbil are options under evaluation in clinical trials. Finally, the HeartMate 3 magnetically levitated centrifugal left ventricular assist device (LVAD) has extended 5-year survival for stage D HF patients who are candidates for an LVAD. |
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فهرسة مساهمة: | Keywords: HeartMate 3 left ventricular assist device (LVAD); angiotensin receptor/neprilysin inhibitors (ARNIs); heart failure with reduced ejection fraction (HFrEF); novel therapies; quadruple medical therapy; sodium-glucose co-transporter-2 inhibitors (SGLT2) |
المشرفين على المادة: | 2M19539ERK (omecamtiv mecarbil) 26NAK24LS8 (Hydralazine) IA7306519N (Isosorbide Dinitrate) 0 (Angiotensin Receptor Antagonists) 8W8T17847W (Urea) |
تواريخ الأحداث: | Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240330 |
رمز التحديث: | 20240330 |
مُعرف محوري في PubMed: | PMC10969833 |
DOI: | 10.3390/ijms25063113 |
PMID: | 38542088 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
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DOI: | 10.3390/ijms25063113 |