دورية أكاديمية
أعرض في EDS

Expression of Rejection-Associated Transcripts in Early Protocol Renal Transplant Biopsies Is Associated with Tacrolimus Exposure and Graft Outcome.

التفاصيل البيبلوغرافية
العنوان: Expression of Rejection-Associated Transcripts in Early Protocol Renal Transplant Biopsies Is Associated with Tacrolimus Exposure and Graft Outcome.
المؤلفون: Chamoun B; Nephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Department of Medicine, Autonomous University of Barcelona, 08035 Barcelona, Spain., Torres IB; Nephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Department of Medicine, Autonomous University of Barcelona, 08035 Barcelona, Spain.; Laboratory of Nephrology and Transplantation, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain., Gabaldón A; Pathology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain., Jouvé T; Laboratory of Nephrology and Transplantation, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.; Renal Transplant Unit, Nephrology Department, Grenoble University Hospital, 38043 Grenoble, France., Meneghini M; Nephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Laboratory of Nephrology and Transplantation, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain., Zúñiga JM; Nephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Laboratory of Nephrology and Transplantation, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain., Sellarés J; Nephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Laboratory of Nephrology and Transplantation, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain., Perelló M; Nephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain., Serón D; Nephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain., Bestard O; Nephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Department of Medicine, Autonomous University of Barcelona, 08035 Barcelona, Spain.; Laboratory of Nephrology and Transplantation, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain., Moreso F; Nephrology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.; Department of Medicine, Autonomous University of Barcelona, 08035 Barcelona, Spain.; Laboratory of Nephrology and Transplantation, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Mar 10; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Kidney Transplantation*/adverse effects, Humans ; Tacrolimus/adverse effects ; Graft Rejection/genetics ; Biopsy ; Immunosuppression Therapy ; Immunosuppressive Agents/adverse effects
مستخلص: Subclinical inflammation in protocol biopsies relates to tacrolimus exposure and human leukocyte antigen (HLA) matching. We aimed to characterize transcripts associated with rejection and tacrolimus exposure and the latter's association with transplant outcomes. We tested whether gene expression is associated with rejection using strictly normal protocol biopsies (n = 17) and biopsies with T cell-mediated rejection (TCMR) or antibody-mediated rejection (ABMR) according to Banff criteria (n = 12). Subsequently, we analyzed these transcripts in a set of 4-month protocol biopsies (n = 137) to assess their association with donor and recipient characteristics, the intensity of immunosuppression, and the graft outcome. Differential expression (false discovery rate (FDR) < 0.01, fold (change (FC) > 3) between normal and rejection biopsies yielded a set of 111 genes. In the protocol biopsy cohort (n = 137), 19 out of these 111 genes correlated with tacrolimus trough levels at the time of biopsy (TAC-C 0 ), and unsupervised analysis split this cohort into two clusters. The two clusters differed in donor age and tacrolimus trough levels. Subclinical rejection, including borderline lesions, tended to occur in the same cluster. Logistic regression analysis indicated that TAC-C 0 at the time of biopsy (OR: 0.83, 95%CI:0.72-0.06, p = 0.0117) was associated with cluster 2. In a follow-up averaging 70 ± 30 months, this patient group displayed a significant decline in renal function ( p = 0.0135). The expression of rejection-associated transcripts in early protocol biopsies is associated with tacrolimus exposure and a faster decline in renal function.
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فهرسة مساهمة: Keywords: biopsies; gene expression; rejection; renal transplantation; tacrolimus
المشرفين على المادة: WM0HAQ4WNM (Tacrolimus)
0 (Immunosuppressive Agents)
تواريخ الأحداث: Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240330
رمز التحديث: 20240330
مُعرف محوري في PubMed: PMC10970018
DOI: 10.3390/ijms25063189
PMID: 38542163
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms25063189