دورية أكاديمية
A Monocarbonyl Curcuminoid Derivative Inhibits the Activity of Human Glutathione Transferase A4-4 and Chemosensitizes Glioblastoma Cells to Temozolomide.
العنوان: | A Monocarbonyl Curcuminoid Derivative Inhibits the Activity of Human Glutathione Transferase A4-4 and Chemosensitizes Glioblastoma Cells to Temozolomide. |
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المؤلفون: | Tsouri S; Laboratory of Enzyme Technology, Department of Biotechnology, School Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece., Tselo E; Laboratory of Enzyme Technology, Department of Biotechnology, School Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece., Premetis GE; Laboratory of Enzyme Technology, Department of Biotechnology, School Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece., Furlan V; Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia., Pantiora PD; Laboratory of Enzyme Technology, Department of Biotechnology, School Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece., Mavroidi B; Institute of Biosciences & Applications, National Centre for Scientific Research 'Demokritos', 15310 Athens, Greece., Matiadis D; Institute of Biosciences & Applications, National Centre for Scientific Research 'Demokritos', 15310 Athens, Greece.; Department of Biomedical Sciences, University of West Attica, Egaleo Park Campus, 12243 Athens, Greece., Pelecanou M; Institute of Biosciences & Applications, National Centre for Scientific Research 'Demokritos', 15310 Athens, Greece., Papageorgiou AC; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20521 Turku, Finland., Bren U; Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia.; Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Glagoljaška 8, SI-6000 Koper, Slovenia.; Institute of Environmental Protection and Sensors, Beloruska Ulica 7, SI-2000 Maribor, Slovenia., Sagnou M; Institute of Biosciences & Applications, National Centre for Scientific Research 'Demokritos', 15310 Athens, Greece., Labrou NE; Laboratory of Enzyme Technology, Department of Biotechnology, School Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, 11855 Athens, Greece. |
المصدر: | Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 Mar 11; Vol. 17 (3). Date of Electronic Publication: 2024 Mar 11. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c2004- |
مستخلص: | Human glutathione transferase A4-4 (hGSTA4-4) displays high catalytic efficiency towards 4-hydroxyalkenals and other cytotoxic and mutagenic products of radical reactions and lipid peroxidation. Its role as a target for the chemosensitization of cancer cells has not been investigated so far. In this study, the inhibitory potency of twelve selected natural products and ten monocarbonyl curcumin derivatives against hGSTA4-4 was studied. Among natural products, ellagic acid turned out to be the strongest inhibitor with an IC |
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معلومات مُعتمدة: | P2-0046, P2-0438, L2-3175, J1-4398, L2-4430, J3-4498, J7-4638, J1-4414, J3-4497, J4-4633, I0-E015, and J1-2471 Slovenian Research and Innovation Agency (ARIS) program; NOO Slovenian Ministry of Science and Education |
فهرسة مساهمة: | Keywords: GST inhibition; chemoresistance; chemosensitization; curcumin; ellagic acid; glioblastoma; human glutathione transferase A4-4; monocarbonyl curcumin derivatives; temozolomide sensitization |
تواريخ الأحداث: | Date Created: 20240328 Latest Revision: 20240330 |
رمز التحديث: | 20240330 |
مُعرف محوري في PubMed: | PMC10974579 |
DOI: | 10.3390/ph17030365 |
PMID: | 38543151 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1424-8247 |
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DOI: | 10.3390/ph17030365 |