دورية أكاديمية
أعرض في EDS

Epidemiology of the SARS-CoV-2 Omicron Variant Emergence in the Southeast Brazilian Population.

التفاصيل البيبلوغرافية
العنوان: Epidemiology of the SARS-CoV-2 Omicron Variant Emergence in the Southeast Brazilian Population.
المؤلفون: Rodrigues ES; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., Slavov SN; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., de La Roque DGL; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., Santos EV; Butantan Institute, São Paulo 05585-000, SP, Brazil., Borges JS; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., Evaristo M; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., da Costa PNM; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., de Matos Maçonetto J; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., Marques AA; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., Baccarin AD; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., Oliveira RAM; Butantan Institute, São Paulo 05585-000, SP, Brazil., Junior WL; Butantan Institute, São Paulo 05585-000, SP, Brazil., Benincasa BI; Butantan Institute, São Paulo 05585-000, SP, Brazil., de Andrade da Cruz LM; Butantan Institute, São Paulo 05585-000, SP, Brazil., Lima ARJ; Butantan Institute, São Paulo 05585-000, SP, Brazil., Ribeiro G; Butantan Institute, São Paulo 05585-000, SP, Brazil., Viala VL; Butantan Institute, São Paulo 05585-000, SP, Brazil., de Lima LPO; Butantan Institute, São Paulo 05585-000, SP, Brazil., Martins AJ; Butantan Institute, São Paulo 05585-000, SP, Brazil., Dos Santos Barros CR; Butantan Institute, São Paulo 05585-000, SP, Brazil., Marqueze EC; Butantan Institute, São Paulo 05585-000, SP, Brazil., de Souza Todao Bernardino J; Butantan Institute, São Paulo 05585-000, SP, Brazil., Grotto RMT; School of Agricultural Sciences, São Paulo State University (UNESP), Botucatu 18610-034, SP, Brazil., Souza-Neto JA; Department of Diagnostic Medicine/Pathobiology, Kansas State Veterinary Diagnostic Laboratory College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA., Fonseca V; Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília 70075-900, DF, Brazil., Nogueira ML; Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil., Fukumasu H; Department of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo, Pirassununga 05508-270, SP, Brazil., Coutinho LL; Centro de Genômica Funcional da ESALQ, University of São Paulo, Piracicaba 13418-900, SP, Brazil., Calado RT; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil., Covas DT; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.; Butantan Institute, São Paulo 05585-000, SP, Brazil., Giovanetti M; Laboratorio de Flavivirus, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, Brazil.; Department of Science and Technology for Humans and the Environment, University of Campus Bio-Medico di Roma, 00128 Rome, Italy., Alcantara LCJ; Laboratorio de Flavivirus, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, RJ, Brazil., Sampaio SC; Butantan Institute, São Paulo 05585-000, SP, Brazil., Elias MC; Butantan Institute, São Paulo 05585-000, SP, Brazil., Kashima S; Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14051-140, SP, Brazil.
المصدر: Microorganisms [Microorganisms] 2024 Feb 23; Vol. 12 (3). Date of Electronic Publication: 2024 Feb 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101625893 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2607 (Print) Linking ISSN: 20762607 NLM ISO Abbreviation: Microorganisms Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: The aim of this study was to describe epidemiological characteristics and perform SARS-CoV-2 genomic surveillance in the southeastern region of São Paulo State. During the first months of 2022, we compared weekly SARS-CoV-2 infection prevalence considering age, Ct value, and variants' lineages. An increase in the number of SARS-CoV-2-positive cases until the fourth epidemiological week of 2022 was observed. From the fourth epidemiological week onwards, the number of tests for SARS-CoV-2 diagnosis began to decrease, but the number of positive samples for SARS-CoV-2 remained high, reaching its most expressive level with a rate of 60% of infected individual cases. In this period, we observed a progressive increase in SARS-CoV-2 infection within the 0-10 age group throughout the epidemiological weeks, from 2.8% in the first epidemiological week to 9.2% in the eighth epidemiological week of 2022. We further observed significantly higher Ct values within younger patient samples compared to other older age groups. According to lineage assignment, SARS-CoV-2 (BA.1) was the most prevalent (74.5%) in the younger group, followed by BA.1.1 (23%), BA.2 (1.7%), and Delta (1%). Phylogenetic analysis showed that BA.2 sequences clustered together, indicating sustained transmission of this Omicron VOC sub-lineage by that time. Our results suggest the initial dissemination steps of the Omicron's sub-linage BA.2 into the younger group, due to specific genomic features of the detected sequences. These data provide interesting results related to the spread, emergence, and evolution of the Omicron variant in the southeast Brazilian population.
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معلومات مُعتمدة: 2020/10127- 1 São Paulo Research Foundation; 2020/06441-2 São Paulo Research Foundation; APO21-00010098 PAHO Foundation
فهرسة مساهمة: Keywords: Brazilian population; Omicron variant; SARS-CoV-2 genomic surveillance
تواريخ الأحداث: Date Created: 20240328 Latest Revision: 20240330
رمز التحديث: 20240330
مُعرف محوري في PubMed: PMC10974166
DOI: 10.3390/microorganisms12030449
PMID: 38543500
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-2607
DOI:10.3390/microorganisms12030449