دورية أكاديمية
أعرض في EDS

Antiviral and Virucidal Activities of Uncaria tomentosa (Cat's Claw) against the Chikungunya Virus.

التفاصيل البيبلوغرافية
العنوان: Antiviral and Virucidal Activities of Uncaria tomentosa (Cat's Claw) against the Chikungunya Virus.
المؤلفون: de Lima RC; Laboratório das Interações Vírus Hospedeiros, Instituto Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil., Valente LMM; Instituto de Química, Universidade Federal do Rio de Janeiro, Av. Athos da Silveira Ramos, 149, Rio de Janeiro 21941-909, Brazil., Familiar Macedo D; Laboratório das Interações Vírus Hospedeiros, Instituto Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil., de-Oliveira-Pinto LM; Laboratório das Interações Vírus Hospedeiros, Instituto Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil., Dos Santos FB; Laboratório das Interações Vírus Hospedeiros, Instituto Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil., Mazzei JL; Laboratório de Tecnologia para Biodiversidade em Saúde, Instituto de Tecnologia de Fármacos, Fundação Oswaldo Cruz, Rio de Janeiro 21041-250, Brazil., Siani AC; Laboratório de Tecnologia para Biodiversidade em Saúde, Instituto de Tecnologia de Fármacos, Fundação Oswaldo Cruz, Rio de Janeiro 21041-250, Brazil., Nunes PCG; Laboratório das Interações Vírus Hospedeiros, Instituto Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil., de Azeredo EL; Laboratório das Interações Vírus Hospedeiros, Instituto Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil.
المصدر: Viruses [Viruses] 2024 Feb 27; Vol. 16 (3). Date of Electronic Publication: 2024 Feb 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Cat's Claw* , Chikungunya virus* , Plants, Medicinal* , Chikungunya Fever*/drug therapy, Plant Extracts/pharmacology ; Antiviral Agents/pharmacology
مستخلص: Uncaria tomentosa (UT) is a medicinal plant popularly known as cat's claw belonging to the Rubiaceae family that has been reported to display antiviral and anti-inflammatory activities. The chikungunya virus (CHIKV) outbreaks constitute a Brazilian public health concern. CHIKV infection develops an abrupt onset of fever, usually accompanied by a skin rash, besides incapacitating polyarthralgia. There is no vaccine available or treatment for CHIKV infection. The present study evaluates the hydroalcoholic extract of UT bark as a potential antiviral against CHIKV. The in vitro antiviral activity of the UT extract against the Brazilian CHIKV strain was assessed using quantitative reverse transcription polymerase chain reaction, flow cytometry, and plaque assay. Results obtained demonstrated that UT inhibits CHIKV infection in a dose-dependent manner. At the non-cytotoxic concentration of 100 µg/mL, UT exhibited antiviral activity above 90% as determined by plaque reduction assay, and it reduced the viral cytopathic effect. Similarly, a significant virucidal effect of 100 µg/mL UT was observed after 24 and 48 h post-infection. This is the first report on the antiviral activity of UT against CHIKV infection, and the data presented here suggests UT as a potential antiviral to treat CHIKV infection.
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معلومات مُعتمدة: E-26/201.244/2021 Fundação Carlos Chagas Filho de Amparo à pesquisa do Estado do Rio de Janeiro; E-26/211.344/2021 Faperj; E-26/210.268/2019 Faperj
فهرسة مساهمة: Keywords: Chikungunya; Uncaria tomentosa; antiviral and virucidal effects; cat’s claw
المشرفين على المادة: 0 (Plant Extracts)
0 (Antiviral Agents)
تواريخ الأحداث: Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240522
رمز التحديث: 20240522
مُعرف محوري في PubMed: PMC10974475
DOI: 10.3390/v16030369
PMID: 38543735
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v16030369