دورية أكاديمية
أعرض في EDS

Evaluation of the effectiveness of Berberis integerrima Bunge root extract combined with spearmint essential oil in the treatment of acne vulgaris: A randomized controlled clinical trial.

التفاصيل البيبلوغرافية
العنوان: Evaluation of the effectiveness of Berberis integerrima Bunge root extract combined with spearmint essential oil in the treatment of acne vulgaris: A randomized controlled clinical trial.
المؤلفون: Saeidi S; Students Research Committee, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran., Ghanadian SM; Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.; Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran., Poostiyan N; Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.; Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran., Soltani R; Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.; Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
المصدر: Journal of cosmetic dermatology [J Cosmet Dermatol] 2024 Jul; Vol. 23 (7), pp. 2458-2466. Date of Electronic Publication: 2024 Mar 28.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Blackwell Science, c2002-
مواضيع طبية MeSH: Acne Vulgaris*/drug therapy , Oils, Volatile*/administration & dosage , Plant Extracts*/administration & dosage , Plant Extracts*/therapeutic use , Plant Roots*/chemistry , Berberis*/chemistry, Humans ; Male ; Female ; Young Adult ; Adult ; Treatment Outcome ; Adolescent ; Severity of Illness Index ; Phytotherapy ; Mentha spicata/chemistry ; Anti-Bacterial Agents/administration & dosage ; Clindamycin/administration & dosage ; Clindamycin/therapeutic use ; Administration, Cutaneous
مستخلص: Background: Acne vulgaris is one of the most common dermatological disorders. Berberis integerrima Bunge belongs to the Berberidaceae family. Several studies on different Berberis species in addition to B. integerrima have shown antimicrobial, antioxidant, and anti-inflammatory effects. Spearmint essential oil also has antioxidant, antibacterial, and anti-inflammatory activities. This study aimed to evaluate the clinical effectiveness of the topical combination of B. integerrima root extract and spearmint essential oil in the treatment of acne vulgaris.
Methods: Patients with mild to moderate facial acne who met the inclusion criteria were randomly assigned to either drug (B. integerrima extract/spearmint essential oil topical solution) or control (clindamycin 1% topical solution) groups. Each group applied the solution twice a day for 4 weeks. Before and at the end of the intervention, the number of lesions and mGAGS (Modified Global Acne Grading Scale) score were recorded.
Results: Thirty patients in each group of drug and control completed the study. Topical B.integerrima root extract/spearmint essential oil significantly reduced the number of lesions (27.33 ± 26.17 vs. 21.58 ± 21.10; p < 0.001) and mGAGS (18.76 ± 8.61 vs. 13.87 ± 8.14; p < 0.001) at the end of the intervention. However, there was no significant difference between the two groups regarding the number of lesions (p = 0.906) and mGAGS (p = 0.882).
Conclusions: B. integerrima root extract combined with spearmint essential oil has significant anti-acne effects, comparable to topical antibiotic clindamycin. It could be considered as a potential treatment for acne vulgaris. However, more studies with larger sample sizes and longer durations are required to confirm this effect.
(© 2024 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.)
References: Leung AK, Barankin B, Lam JM, Leong KF, Hon KL. Dermatology: how to manage acne vulgaris. Drugs Context. 2021;10:2021‐8‐6.
Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5):945‐973. e33.
Kircik LH. What's new in the management of acne vulgaris. Cutis. 2019;104(1):48‐52.
Vasam M, Korutla S, Bohara RA. Acne vulgaris: a review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochem Biophys Rep. 2023;36:101578.
Oge' LK, Broussard A, Marshall MD. Acne vulgaris: diagnosis and treatment. Am Fam Physician. 2019;100(8):475‐484.
Alshammrie FF, Alshammari R, Alharbi RM, Khan FH, Alshammari SK. Epidemiology of acne vulgaris and its association with lifestyle among adolescents and young adults in Hail, Kingdom of Saudi Arabia: a community‐based study. Cureus. 2020;12(7):e9277.
Barnes LE, Levender MM, Fleischer AB Jr, Feldman SR. Quality of life measures for acne patients. Dermatol Clin. 2012;30(2):293‐300.
Santer M, Burden‐Teh E, Ravenscroft J. Managing acne vulgaris: an update. Drug Ther Bull. 2023;62(1):6‐10.
Eichenfield DZ, Sprague J, Eichenfield LF. Management of acne vulgaris: a review. JAMA. 2021;326(20):2055‐2067.
Habeshian KA, Cohen BA. Current issues in the treatment of acne vulgaris. Pediatrics. 2020;145(Suppl 2):S225‐S230.
Mohsin N, Hernandez LE, Martin MR, Does AV, Nouri K. Acne treatment review and future perspectives. Dermatol Ther. 2022;35(9):e15719.
Cooper AJ. Systematic review of Propionibacterium acnes resistance to systemic antibiotics. Med J Aust. 1998;169(5):259‐261.
Ashraf H, Heidari R, Nejati V. Antihyperglycemic and antihyperlipidemic effects of fruit aqueous extract of Berberis integerrima Bge. In Streptozotocin‐induced diabetic rats. Iran J Pharm Res. 2014;13(4):1313‐1318.
Alemardan A, Asadi W, Rezaei M, Tabrizi L, Mohammadi S. Cultivation of Iranian seedless barberry (Berberis integerrima ‘Bidaneh’): a medicinal shrub. Ind Crop Prod. 2013;50:276‐287.
Sabahi Z, Farmani F, Soltani F, Moein M. DNA protection, antioxidant and xanthine oxidase inhibition activities of polyphenol‐enriched fraction of Berberis integerrima Bunge fruits. Iran J Basic Med Sci. 2018;21(4):411‐416.
Azimi G, Hakakian A, Ghanadian M, Joumaa A, Alamian S. Bioassay‐directed isolation of quaternary benzylisoquinolines from Berberis integerrima with bactericidal activity against Brucella abortus. Res Pharm Sci. 2018;13(2):149‐158.
Gholampour F, Masoudi R, Khaledi M, et al. Berberis integerrima hydro‐alcoholic root extract and its constituent berberine protect against cisplatin‐induced nephro‐ and hepato‐toxicity. Am J Med Sci. 2022;364(1):76‐87.
Hajhashemi V, Fahmideh F, Ghanadian M. Antinociceptive effect of methanolic extract and alkaloid fractions of Berberis integerrima root in animal models. Avicenna J Phytomed. 2018;8(3):227‐236.
Bayani M, Ahmadi‐hamedani M, Jebelli JA. Phytochemical and antioxidant activities of Berberis integerrima and Berberis vulgaris and pharmacological effects of the more active species on alloxan‐induced diabetic rats. J Med Plants. 2016;15(59):111‐121.
Sabahi Z, Khoshnood‐Mansoorkhani MJ, Rahmani Namadi S, Moein M. Antidiabetic and synergistic effects study of anthocyanin fraction from Berberis integerrima fruit on streptozotocin‐induced diabetic rats model. Trends Pharmacol Sci. 2016;2(1):43‐50.
El Menyiy N, Mrabti HN, El Omari N, et al. Medicinal uses, phytochemistry, pharmacology, and toxicology of Mentha spicata. Evid Based Complement Alternat Med. 2022;2022:7990508.
Soltani R, Ghanadian SM, Iraj B, Homayouni A, Esfahani TS, Akbari M. The effects of Berberis integerrima fruit extract on glycemic control parameters in patients with type 2 diabetes mellitus: a randomized controlled clinical trial. Evid Based Complement Alternat Med. 2021;2021:5583691.
Hosseini ES, Majidi MM, Ehtemam MH, Ghanadian M. Genetic variability for phytochemical components in fennel genotypes. Crop Sci. 2021;61(6):4081‐4086.
Purdy S, de Berker D. Acne vulgaris. BMJ Clin Evid. 2011;2011:1714.
shahmoradi Z et al. Comparison of topical 5% nicotinamid gel versus 2% clindamycin gel in the treatment of the mild‐moderate acne vulgaris: a double‐blinded randomized clinical trial. J Res Med Sci. 2013;18(2):115‐117.
Ke X, Zhang R, Li P, et al. Hydrochloride berberine ameliorates alcohol‐induced liver injury by regulating inflammation and lipid metabolism. Biochem Biophys Res Commun. 2022;610:49‐55.
Soleymani S, Farzaei MH, Zargaran A, Niknam S, Rahimi R. Promising plant‐derived secondary metabolites for treatment of acne vulgaris: a mechanistic review. Arch Dermatol Res. 2020;312(1):5‐23.
Noh JW, Jun MS, Yang HK, Lee BC. Cellular and molecular mechanisms and effects of berberine on obesity‐induced inflammation. Biomedicine. 2022;10(7):1739.
Ma J, Chan CC, Huang WC, Kuo ML. Berberine inhibits pro‐inflammatory cytokine‐induced IL‐6 and CCL11 production via modulation of STAT6 pathway in human bronchial epithelial cells. Int J Med Sci. 2020;17(10):1464‐1473.
Kassab RB, Vasicek O, Ciz M, Lojek A, Perecko T. The effects of berberine on reactive oxygen species production in human neutrophils and in cell‐free assays. Interdiscip Toxicol. 2017;10(2):61‐65.
Peng L, Kang S, Yin Z, et al. Antibacterial activity and mechanism of berberine against Streptococcus agalactiae. Int J Clin Exp Pathol. 2015;8(5):5217‐5223.
Jian‐ling JIN, Guo‐qiang HUA, Zhen MENG, Pei‐ji GAO. Antibacterial mechanisms of berberine and reasons for little resistance of bacteria. Chin Herb Med. 2011;3(1):27‐35.
Wu S, Yang K, Hong Y, et al. A new perspective on the antimicrobial mechanism of berberine hydrochloride against Staphylococcus aureus revealed by untargeted metabolomic studies. Front Microbiol. 2022;13:917414.
El‐Zahar KM, Al‐Jamaan ME, Al‐Mutairi FR, Al‐Hudiab AM, Al‐Einzi MS, Mohamed AA. Antioxidant, antibacterial, and antifungal activities of the ethanolic extract obtained from Berberis vulgaris roots and leaves. Molecules. 2022;27(18):6114.
Daud FS, Pande G, Joshi M, Pathak R, Wankhede S. A study of antibacterial effect of some selected essential oils and medicinal herbs against acne causing bacteria. Int J Pharm Sci Invent. 2013;2(1):27‐34.
Prasad SB, Kaur D. In vitro anti acne activity of ethanolic extract of stem of Berberis aristata. Intern J Pharmacog Phytochem Res. 2017;9(2):190‐192.
Prasad SB, Kaur D. Formulation of topical gel from extract of Berberis aristata DC for acne. Intern J Drug Delivery Technol. 2019;9(1):104‐108.
Banu A, Humnekar A. A prospective study to determine the effectiveness of clindamycin (allopathy), Berberis aquifolium (oregon grape‐homeopathy) and Azadirachta indica (neem‐ayurvedic) medications against the microorganism causing acne vulgaris. Int J Basic Med Sci. 2011;2(2):78‐83.
Slobodnikova L, Kost'alova D, Labudova D, Kotulova D, Kettmann V. Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids. Phytother Res. 2004;18(8):674‐676.
Lu K, Lin H. Effect of berberine on hyperandrogenemia, ovulation dysfunction and inflammation in a mouse model of polycystic ovary syndrome. Trop J Pharm Res. 2020;19(9):1963‐1968.
Li L, Li C, Pan P, et al. A single arm pilot study of effects of berberine on the menstrual pattern, ovulation rate, hormonal and metabolic profiles in anovulatory Chinese women with polycystic ovary syndrome. PLoS ONE. 2015;10(12):e0144072.
Zhang S, Zhou J, Gober H‐J, Leung WT, Wang L. Effect and mechanism of berberine against polycystic ovary syndrome. Biomed Pharmacother. 2021;138:111468.
Seki T, Morohashi M. Effect of some alkaloids, flavonoids and triterpenoids, contents of Japanese‐Chinese traditional herbal medicines, on the lipogenesis of sebaceous glands. Skin Pharmacol. 1993;6(1):56‐60.
Nimisha RDA, Fatima Z, Neema KCD. Antipsoriatic and anti‐inflammatory studies of Berberis aristata extract loaded nanovesicular gels. Pharmacogn Mag. 2017;13(3):S587‐S594.
Gupta SK, Agarwal R, Srivastava S, et al. The anti‐inflammatory effects of Curcuma longa and Berberis aristata in endotoxin‐induced uveitis in rabbits. Invest Ophthalmol Vis Sci. 2008;49(9):4036‐4040.
Küpeli E, Koşar M, Yeşilada E, Hüsnü K, Başer C. A comparative study on the anti‐inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species. Life Sci. 2002;72(6):645‐657.
Fouladi RF. Aqueous extract of dried fruit of Berberis vulgaris L. in acne vulgaris, a clinical trial. J Diet Suppl. 2012;9(4):253‐261.
Johnson M, Rafikhah N. Berberis vulgaris juice and acne vulgaris: a placebo‐controlled study. Asian J Clini Nutr. 2014;6(2):47‐52.
Hussain AI, Anwar F, Shahid M. Chemical composition, and antioxidant and antimicrobial activities of essential oil of spearmint (Mentha spicata L.) from Pakistan. J Essent Oil Res. 2010;22(1):78‐84.
Arumugam P, Murugan R, Subathra M, Ramesh A. Superoxide radical scavenging and antibacterial activities of different fractions of ethanol extract of Mentha spicata (L.). Med Chem Res. 2010;19(7):664‐673.
Talbaoui A. Chemical composition and antibacterial activity of essential oils from six Moroccan plants. J Med Plant Res. 2012;6(31):4593‐4600.
dos Santos Franciscato LM, da Silva MR, Andrich F, et al. Chemical characterization and antimicrobial activity of essential oils of mint (Mentha spicata L.) and Surinam cherry (Eugenia uniflora L.). Orbital: the electronic. J Chem. 2018;10:475‐481.
Akdoğan M, Tamer MN, Cüre E, Cüre MC, Köroğlu BK, Delibaş N. Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. Phytother Res. 2007;21(5):444‐447.
Grant P. Spearmint herbal tea has significant anti‐androgen effects in polycystic ovarian syndrome. A randomized controlled trial. Phytother Res. 2010;24(2):186‐188.
فهرسة مساهمة: Keywords: Herbal extracts; acne vulgaris; clinical trial
المشرفين على المادة: 0 (Oils, Volatile)
0 (Plant Extracts)
0 (Anti-Bacterial Agents)
3U02EL437C (Clindamycin)
تواريخ الأحداث: Date Created: 20240328 Date Completed: 20240619 Latest Revision: 20240808
رمز التحديث: 20240809
DOI: 10.1111/jocd.16291
PMID: 38545754
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-2165
DOI:10.1111/jocd.16291