دورية أكاديمية
أعرض في EDS

Association of COX-2, TNF-α, TLR4, and IKKα With Survival of Patients With Oral Squamous Cell Carcinomas: A Systematic Review.

التفاصيل البيبلوغرافية
العنوان: Association of COX-2, TNF-α, TLR4, and IKKα With Survival of Patients With Oral Squamous Cell Carcinomas: A Systematic Review.
المؤلفون: Biasin FF; School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil., Franco AM; School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil., Louzeiro GC; School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil., Cherubini K; School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil.; Oral Medicine Division, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil., Salum FG; School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil.; Oral Medicine Division, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil.
المصدر: Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2024 Mar 01; Vol. 25 (3), pp. 757-766. Date of Electronic Publication: 2024 Mar 01.
نوع المنشور: Systematic Review; Meta-Analysis; Journal Article
اللغة: English
بيانات الدورية: Publisher: Asian Pacific Organization for Cancer Prevention Country of Publication: Thailand NLM ID: 101130625 Publication Model: Electronic Cited Medium: Internet ISSN: 2476-762X (Electronic) Linking ISSN: 15137368 NLM ISO Abbreviation: Asian Pac J Cancer Prev Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bangkok : Asian Pacific Organization for Cancer Prevention,
مواضيع طبية MeSH: Carcinoma, Squamous Cell*/pathology , Mouth Neoplasms*/pathology , Head and Neck Neoplasms*, Humans ; Squamous Cell Carcinoma of Head and Neck ; Tumor Necrosis Factor-alpha ; I-kappa B Kinase ; Cyclooxygenase 2 ; Toll-Like Receptor 4 ; Prognosis
مستخلص: Background: This review investigated the association of COX-2, TNF-α, TLR4, and IKKα with the survival of patients with oral squamous cell carcinoma (SCC).
Methods: A systematic search was conducted in the databases PUBMED, Web of Science, LILACS, EMBASE, Scopus, and Cochrane Library. The studies should assess the expression of those proteins in the tumor and survival outcomes.
Results: Twenty-one articles were included. The meta-analysis results leaned towards an association of COX-2 overexpression with a lower overall survival. The estimated hazard ratio was 1.51 (95% CI 0.97, 2.33), but not statistically significant (p=0.07). A low heterogeneity was observed (I2=0%). Regarding TNF-α, TLR4, and IKKα, statistically significant results for the association with survival were presented, but there was not enough data to a meta-analysis.
Conclusion: COX-2 overexpression may be associated with a poorer prognosis in oral SCC. The insufficiency of studies about TNF-α, TLR4, and IKKα restrained their validation as predictors of prognosis.
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فهرسة مساهمة: Keywords: Tumor necrosis factor α , Cyclooxygenase 2, Kinase I𝜅B α Toll-like receptor 4; oral cancer
المشرفين على المادة: 0 (Tumor Necrosis Factor-alpha)
EC 2.7.11.10 (I-kappa B Kinase)
EC 1.14.99.1 (Cyclooxygenase 2)
0 (Toll-Like Receptor 4)
0 (TLR4 protein, human)
تواريخ الأحداث: Date Created: 20240328 Date Completed: 20240329 Latest Revision: 20240607
رمز التحديث: 20240607
مُعرف محوري في PubMed: PMC11152409
DOI: 10.31557/APJCP.2024.25.3.757
PMID: 38546058
قاعدة البيانات: MEDLINE
الوصف
تدمد:2476-762X
DOI:10.31557/APJCP.2024.25.3.757