دورية أكاديمية
IgG4-related disease complicated with diffuse and chronic gastrointestinal inflammation leading to small intestinal perforation.
| العنوان: | IgG4-related disease complicated with diffuse and chronic gastrointestinal inflammation leading to small intestinal perforation. |
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| المؤلفون: | Ino K; Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan., Arinuma Y; Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan., Akiya M; Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan., Kajita S; Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan., Okina S; Department of Hematology, Kitasato University School of Medicine, Kanagawa, Japan., Sakamoto J; Department of Gastrointestinal Surgery, Ageo Central General Hospital, Saitama, Japan., Tanaka T; Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan., Matsueda Y; Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan., Wada T; Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan., Tanaka S; Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan., Oku K; Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan., Yamaoka K; Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan. |
| المصدر: | Modern rheumatology case reports [Mod Rheumatol Case Rep] 2024 Jul 08; Vol. 8 (2), pp. 323-328. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101761026 Publication Model: Print Cited Medium: Internet ISSN: 2472-5625 (Electronic) Linking ISSN: 24725625 NLM ISO Abbreviation: Mod Rheumatol Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Oxford : Oxford University Press Original Publication: Abingdon, Oxfordshire : Taylor & Francis, [2017]- |
| مواضيع طبية MeSH: | Immunoglobulin G4-Related Disease*/complications , Immunoglobulin G4-Related Disease*/diagnosis , Intestinal Perforation*/etiology , Intestinal Perforation*/diagnosis , Intestinal Perforation*/surgery , Intestine, Small*/pathology, Humans ; Female ; Aged ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Chronic Disease ; Treatment Outcome ; Inflammation/diagnosis ; Inflammation/etiology ; Glucocorticoids/therapeutic use ; Glucocorticoids/administration & dosage |
| مستخلص: | Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a systemic inflammatory disease characterised by elevated serum IgG4, IgG4+ cell infiltration, storiform fibrosis, and obliterative phlebitis. While IgG4-RD can affect various organs, gastrointestinal tract involvement is less common. Here, we report a 70-year-old female with IgG4-RD complicated with diffuse and chronic gastrointestinal inflammation, which led to small intestinal perforation. She had been suffering from anorexia, abdominal pain, vomiting, and diarrhoea and hospitalised due to recurrent ileus. Consequently, she was referred due to small intestinal perforation required for surgical intervention. Pathology revealed acute and chronic inflammation with massive IgG4+ plasmacyte infiltration into mucosa of the small intestine and ischaemic change secondarily caused by chronic inflammation. Random biopsies from the mucosa of stomach, duodenum, ileum, and colon also revealed diffuse and massive IgG4+ plasmacyte infiltration in stomach, duodenum, small intestine, and colon. She was diagnosed with IgG4-RD based on the pathological findings and elevated serum IgG4 levels. Glucocorticoid rapidly ameliorated the symptoms. IgG4-RD may cause gastrointestinal manifestations, and histopathological assessment should be considered, even in the absence of specific characteristics of IgG4-RD. (© Japan College of Rheumatology 2024. Published by Oxford University Press.) |
| فهرسة مساهمة: | Keywords: Immunoglobulin (Ig) G4–related disease (IgG4-RD); diffuse and chronic gastrointestinal inflammation; glucocorticoid; ileus; small intestinal perforation |
| المشرفين على المادة: | 0 (Immunoglobulin G) 0 (Glucocorticoids) |
| تواريخ الأحداث: | Date Created: 20240328 Date Completed: 20240708 Latest Revision: 20240708 |
| رمز التحديث: | 20240709 |
| DOI: | 10.1093/mrcr/rxae012 |
| PMID: | 38547341 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2472-5625 |
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| DOI: | 10.1093/mrcr/rxae012 |