دورية أكاديمية
High-resolution diffusion-weighted MRI plus mammography for detecting clinically occult breast cancers in women with dense breasts.
| العنوان: | High-resolution diffusion-weighted MRI plus mammography for detecting clinically occult breast cancers in women with dense breasts. |
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| المؤلفون: | Kim HJ; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Shin HJ; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. Electronic address: docshin@amc.seoul.kr., Baek S; Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Lee CW; Department of Radiology, Gangdong Seongsim Byeongwon, University of Hallym College of Medicine, Seoul, Republic of Korea., Choi WJ; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Chae EY; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Cha JH; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Kim HH; Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea., Moon WK; Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. |
| المصدر: | European journal of radiology [Eur J Radiol] 2024 Jun; Vol. 175, pp. 111440. Date of Electronic Publication: 2024 Mar 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 8106411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7727 (Electronic) Linking ISSN: 0720048X NLM ISO Abbreviation: Eur J Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Science Ireland Ltd Original Publication: Stuttgart ; New York : Thieme, [c1981- |
| مواضيع طبية MeSH: | Breast Neoplasms*/diagnostic imaging , Mammography*/methods , Diffusion Magnetic Resonance Imaging*/methods , Sensitivity and Specificity* , Breast Density*, Humans ; Female ; Middle Aged ; Retrospective Studies ; Adult ; Aged ; Multimodal Imaging/methods ; Reproducibility of Results |
| مستخلص: | Purpose: To compare the performance of mammography, high-resolution DW-MRI, DCE-MRI, and their combinations in detecting clinically occult breast cancer in women with dense breasts. Method: 544 breasts from 281 consecutive asymptomatic women with dense breasts were retrospectively identified. They underwent breast MRI for preoperative evaluation of breast cancers (n = 214) or as supplemental screening (n = 67) including DCE-MRI and DW-MRI (b values, 0 and 1000 sec/mm 2 ; in-plane resolution, 1.1 × 1.1 mm 2 and 1.3 × 1.3 mm 2 ; section thickness, 3 mm), in addition to mammography. Three readers independently reviewed each examination on a per-breast basis. Histopathology and at least two year of imaging follow-up served as the gold standard. The sensitivities and specificities of different imaging modalities were compared using McNemar test. Results: 230 of 544 breasts (42 %) had malignant lesions. The sensitivity of DW-MRI was higher than that of mammography (77.0 % vs 57.9 %; adjusted p < 0.001), but lower than that of DCE-MRI (84.8 %; adjusted p = 0.014). The specificity of DW-MRI was comparable to those of mammography (98.1 % vs 99.1 %; adjusted p > 0.999) and DCE-MRI (97.1 %; adjusted p > 0.999). DW-MRI plus mammography had a comparable sensitivity and specificity to those of DCE-MRI plus mammography (88.6 % vs 90.9 % and 97.1 % vs 96.2 %; adjusted p > 0.999 for both). Conclusions: High-resolution DW-MRI had a sensitivity higher than mammography and lower than DCE-MRI. Nevertheless, DW-MRI plus mammography showed a comparable sensitivity and specificity to DCE-MRI plus mammography for detecting clinically occult cancers in women with dense breasts. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Breast neoplasms; Dense breasts; Diffusion magnetic resonance imaging; Screening |
| تواريخ الأحداث: | Date Created: 20240328 Date Completed: 20240515 Latest Revision: 20240515 |
| رمز التحديث: | 20240516 |
| DOI: | 10.1016/j.ejrad.2024.111440 |
| PMID: | 38547744 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7727 |
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| DOI: | 10.1016/j.ejrad.2024.111440 |