دورية أكاديمية
أعرض في EDS

Obliteration of portal venules contributes to portal hypertension in biliary cirrhosis.

التفاصيل البيبلوغرافية
العنوان: Obliteration of portal venules contributes to portal hypertension in biliary cirrhosis.
المؤلفون: Shan S; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China.; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, PR China., Zhao X; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China.; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, PR China., Wood-Trageser MA; Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA., Hu D; The Second Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, Shandong, PR China., Liu L; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China., Qi B; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, PR China., Jian J; Department of Radiation Oncology, Tianjin Medical University General Hospital, Tianjin, PR China., Wang P; Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China., Lv W; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, PR China., Hu C; School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, PR China.
المصدر: The Journal of pathology [J Pathol] 2024 Jun; Vol. 263 (2), pp. 178-189. Date of Electronic Publication: 2024 Mar 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley And Sons Country of Publication: England NLM ID: 0204634 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9896 (Electronic) Linking ISSN: 00223417 NLM ISO Abbreviation: J Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: Chichester : John Wiley And Sons
Original Publication: London, Oliver & Boyd.
مواضيع طبية MeSH: Hypertension, Portal*/pathology , Hypertension, Portal*/physiopathology , Liver Cirrhosis, Biliary*/pathology , Liver Cirrhosis, Biliary*/complications , Liver Cirrhosis, Biliary*/physiopathology , Portal Vein*/pathology, Animals ; Male ; Humans ; Female ; Venules/pathology ; Rats ; Adult ; Portal Pressure ; Middle Aged ; Disease Models, Animal ; Liver/pathology ; Liver/blood supply ; Rats, Sprague-Dawley ; Bile Ducts/pathology ; Young Adult ; Adolescent
مستخلص: The effects of the obliteration of portal venules (OPV) in cirrhotic portal hypertension are poorly understood. To investigate its contribution to portal hypertension in biliary cirrhosis and its underlying mechanism, we evaluated OPV using two-dimensional (2D) histopathology in liver explants from patients with biliary atresia (BA, n = 63), primary biliary cholangitis (PBC, n = 18), and hepatitis B-related cirrhosis (Hep-B-cirrhosis, n = 35). Then, three-dimensional (3D) OPV was measured by X-ray phase-contrast CT in two parallel models in rats following bile duct ligation (BDL) or carbon tetrachloride (CCl 4 ) administration, representing biliary cirrhosis and post-necrotic cirrhosis, respectively. The portal pressure was also measured in the two models. Finally, the effects of proliferative bile ducts on OPV were investigated. We found that OPV was significantly more frequent in patients with biliary cirrhosis, including BA (78.57 ± 16.45%) and PBC (60.00 ± 17.15%), than that in Hep-B-cirrhotic patients (29.43 ± 14.94%, p < 0.001). OPV occurred earlier, evidenced by the paired liver biopsy at a Kasai procedure (KP), and was irreversible even after a successful KP in the patients with BA. OPV was also significantly more frequent in the BDL models than in the CCl 4 models, as shown by 2D and 3D quantitative analysis. Portal pressure was significantly higher in the BDL model than that in the CCl 4 model. With the proliferation of bile ducts, portal venules were compressed and irreversibly occluded, contributing to the earlier and higher portal pressure in biliary cirrhosis. OPV, as a pre-sinusoidal component, plays a key role in the pathogenesis of portal hypertension in biliary cirrhosis. The proliferated bile ducts and ductules gradually take up the 'territory' originally attributed to portal venules and compress the portal venules, which may lead to OPV in biliary cirrhosis. © 2024 The Pathological Society of Great Britain and Ireland.
(© 2024 The Pathological Society of Great Britain and Ireland.)
References: D'Amico G, Morabito A, D'Amico M, et al. Clinical states of cirrhosis and competing risks. J Hepatol 2018; 68: 563–576.
Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis. Lancet 2014; 383: 1749–1761.
Mokdad AA, Lopez AD, Shahraz S, et al. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med 2014; 12: 145–169.
Sartoris R, Rautou PE, Elkrief L, et al. Quantification of liver surface nodularity at CT: utility for detection of portal hypertension. Radiology 2018; 289: 698–707.
Lee DH, Ahn JH, Chung JW, et al. Varices on computed tomography are surrogate of clinically significant portal hypertension and can predict survival in compensated cirrhosis patients. J Gastroenterol Hepatol 2019; 34: 450–457.
Villanueva C, Albillos A, Genescà J, et al. Development of hyperdynamic circulation and response to β‐blockers in compensated cirrhosis with portal hypertension. Hepatology 2016; 63: 197–206.
Bosch J, Groszmann RJ, Shah VH. Evolution in the understanding of the pathophysiological basis of portal hypertension: how changes in paradigm are leading to successful new treatments. J Hepatol 2015; 62: S121–S130.
Calvaruso V, Burroughs AK, Standish R, et al. Computer‐assisted image analysis of liver collagen: relationship to Ishak scoring and hepatic venous pressure gradient. Hepatology 2009; 49: 1236–1244.
Sethasine S, Jain D, Groszmann RJ, et al. Quantitative histological‐hemodynamic correlations in cirrhosis. Hepatology 2012; 55: 1146–1153.
Nagula S, Jain D, Groszmann RJ, et al. Histological‐hemodynamic correlation in cirrhosis‐a histological classification of the severity of cirrhosis. J Hepatol 2006; 44: 111–117.
Hu DD, Habib S, Li XM, et al. Angiogenesis: a new surrogate histopathological marker is capable of differentiating between mild and significant portal hypertension. Histol Histopathol 2015; 30: 205–212.
Guido M, Alves VAF, Balabaud C, et al. Histology of portal vascular changes associated with idiopathic non‐cirrhotic portal hypertension: nomenclature and definition. Histopathology 2019; 74: 219–226.
Guido M, Sarcognato S, Sacchi D, et al. Pathology of idiopathic non‐cirrhotic portal hypertension. Virchows Arch 2018; 473: 23–31.
Verheij J, Schouten JNL, Komuta M, et al. Histological features in western patients with idiopathic non‐cirrhotic portal hypertension. Histopathology 2013; 62: 1083–1091.
Guido M, Sarcognato S, Sonzogni A, et al. Obliterative portal venopathy without portal hypertension: an underestimated condition. Liver Int 2016; 36: 454–460.
Bezerra JA, Wells RG, Mack CL, et al. Biliary atresia: clinical and research challenges for the twenty‐first century. Hepatology 2018; 68: 1163–1173.
Singh S, Muir AJ, Dieterich DT, et al. American gastroenterological association institute technical review on the role of elastography in chronic liver diseases. Gastroenterology 2017; 152: 1544–1577.
Chen G, Xue P, Zheng S, et al. A pathological scoring system in the diagnosis and judgment of prognosis of biliary atresia. J Pediatr Surg 2015; 50: 2119–2123.
Lee WS, Looi LM. Usefulness of a scoring system in the interpretation of histology in neonatal cholestasis. World J Gastroenterol 2009; 15: 5326.
Lee WS, Chai PF. Clinical features differentiating biliary atresia from other causes of neonatal cholestasis. Ann Acad Med Singapore 2010; 39: 648–654.
Braissant O, Rackayová V, Pierzchala K, et al. Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy. J Hepatol 2019; 71: 505–515.
Xuan R, Zhao X, Hu D, et al. Three‐dimensional visualization of the microvasculature of bile duct ligation‐induced liver fibrosis in rats by x‐ray phase‐contrast imaging computed tomography. Sci Rep 2015; 5: 11500.
Chen RC, Rigon L, Longo R. Comparison of single distance phase retrieval algorithms by considering different object composition and the effect of statistical and structural noise. Opt Express 2013; 21: 7384–7399.
Xie HL, Deng B, Du GH, et al. Latest advances of X‐ray imaging and biomedical applications beamline at SSRF. Nucl Sci Tech 2015; 26: 6–21.
Chen RC, Xie HL, Rigon L, et al. Phase retrieval in quantitative X‐ray microtomography with a single sample‐to‐detector distance. Opt Lett 2011; 36: 1719–1721.
Wu XZ, Liu H. Clinical implementation of X‐ray phase‐contrast imaging: theoretical foundations and design considerations. Med Phys 2003; 30: 2169–2179.
Nemati M, Hajalioghli P, Jahed S, et al. Normal values of spleen length and volume: an ultrasonographic study in children. Ultrasound Med Biol 2016; 42: 1771–1778.
Wanless IR, Nakashima E, Sherman M. Regression of human cirrhosis. morphologic features and the genesis of incomplete septal cirrhosis. Arch Pathol Lab Med 2000; 124: 1599–1607.
Bosch J, Iwakiri Y. The portal hypertension syndrome: etiology, classification, relevance, and animal models. Hepatol Int 2018; 12: 1–10.
Wanless IR, Wong F, Blendis LM, et al. Hepatic and portal vein thrombosis in cirrhosis: possible role in development of parenchymal extinction and portal hypertension. Hepatology 1995; 21: 1238–1247.
Patel KR, Harpavat S, Khan Z, et al. Biliary atresia patients with successful kasai portoenterostomy can present with features of obliterative portal venopathy. J Pediatr Gastroenterol Nutr 2020; 71: 91–98.
Walsh CL, Tafforeau P, Wagner WL, et al. Imaging intact human organs with local resolution of cellular structures using hierarchical phase‐contrast tomography. Nat Methods 2021; 18: 1532–1541.
Xin X, Xu H, Jian J, et al. A method of three‐dimensional branching geometry to differentiate the intrahepatic vascular type in early‐stage liver fibrosis using X‐ray phase‐contrast CT. Eur J Radiol 2022; 148: 110178.
Lv WJ, Zhao XY, Hu DD, et al. Insight into bile duct reaction to obstruction from a three‐dimensional perspective using ex vivo phase‐contrast CT. Radiology 2021; 299: 597–610.
Hu Y, He X, Zhou X, et al. Gypenosides ameliorate ductular reaction and liver fibrosis via inhibition of hedgehog signaling. Front Pharmacol 2022; 13: 1033103.
Zhang L, Hu Y, Qi S, et al. Astragalus saponins and its main constituents ameliorate ductular reaction and liver fibrosis in a mouse model of DDC‐induced cholestatic liver disease. Front Pharmacol 2022; 13: 965914.
معلومات مُعتمدة: 82071922 National Natural Science Foundation of China; 82000569 National Natural Science Foundation of China; 81670545 National Natural Science Foundation of China; 81671683 National Natural Science Foundation of China; 81800543 National Natural Science Foundation of China; 16JCYBJC28600 Natural Science Foundation of Tianjin City in China
فهرسة مساهمة: Keywords: X‐ray phase‐contrast CT (PCCT); biliary atresia; chronic hepatitis B; liver pathology
تواريخ الأحداث: Date Created: 20240329 Date Completed: 20240509 Latest Revision: 20240509
رمز التحديث: 20240510
DOI: 10.1002/path.6273
PMID: 38551075
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-9896
DOI:10.1002/path.6273