دورية أكاديمية
Analysis of nondegradable cyclins reveals distinct roles of the mitotic cyclins in Drosophila meiosis.
| العنوان: | Analysis of nondegradable cyclins reveals distinct roles of the mitotic cyclins in Drosophila meiosis. |
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| المؤلفون: | Bourouh M; Department of Biomedical Sciences, University of Windsor, Windsor, Ontario N9B 3P4, Canada., Dhaliwal R; Department of Biomedical Sciences, University of Windsor, Windsor, Ontario N9B 3P4, Canada., Rai R; Department of Biomedical Sciences, University of Windsor, Windsor, Ontario N9B 3P4, Canada., Qureshi H; Department of Biomedical Sciences, University of Windsor, Windsor, Ontario N9B 3P4, Canada., Swan A; Department of Biomedical Sciences, University of Windsor, Windsor, Ontario N9B 3P4, Canada. |
| المصدر: | G3 (Bethesda, Md.) [G3 (Bethesda)] 2024 Jun 05; Vol. 14 (6). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [Oxford] : Oxford University Press Original Publication: Bethesda, MD : Genetics Society of America, 2011- |
| مواضيع طبية MeSH: | Meiosis* , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Cyclin B*/metabolism , Cyclin B*/genetics , Mitosis* , Cyclins*/metabolism , Cyclins*/genetics, Animals ; Cyclin A/metabolism ; Drosophila/metabolism ; Drosophila/genetics ; Microtubules/metabolism ; Anaphase-Promoting Complex-Cyclosome/metabolism ; Anaphase-Promoting Complex-Cyclosome/genetics ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/genetics |
| مستخلص: | Meiosis is a complex variant of the mitotic cell cycle, and as such relies on many of the same proteins involved in mitosis, but utilizes these in novel ways. As in mitosis, Cdk1 and its cyclin partners, Cyclin A, B, and B3 are required at multiple steps in meiosis. Here, we study the effect of stabilized forms of the three mitotic cyclins to study the consequences of failure to degrade the cyclins in meiosis. We find that stabilized Cyclin B3 promotes ectopic microtubule polymerization throughout the egg, dependent on APC/C activity and apparently due to the consequent destruction of Cyclin A and Cyclin B. We present data that suggests CycB, and possibly CycA, can also promote APC/C activity at specific stages of meiosis. We also present evidence that in meiosis APC/CCort and APC/CFzy are able to target Cyclin B via a novel degron. Overall, our findings highlight the distinct functions of the three mitotic Cdk-cyclin complexes in meiosis. Competing Interests: Conflicts of interest The authors declare no conflict of interest. (© The Author(s) 2024. Published by Oxford University Press on behalf of The Genetics Society of America.) |
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| معلومات مُعتمدة: | RGPIN-2017-05839 Natural Sciences and Engineering Research Council of Canada |
| فهرسة مساهمة: | Keywords: Drosophila; APC/C; cyclin; meiosis |
| المشرفين على المادة: | 0 (Drosophila Proteins) 0 (Cyclin B) 0 (Cyclins) 0 (Cyclin A) EC 2.3.2.27 (Anaphase-Promoting Complex-Cyclosome) 0 (cyclin B3, Drosophila) |
| تواريخ الأحداث: | Date Created: 20240329 Date Completed: 20240605 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| مُعرف محوري في PubMed: | PMC11152073 |
| DOI: | 10.1093/g3journal/jkae066 |
| PMID: | 38551147 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2160-1836 |
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| DOI: | 10.1093/g3journal/jkae066 |