Single nucleotide polymorphism (SNP) rs4291 of the angiotensin-converting enzyme (ACE) gene is associated with the response to losartan treatment in hypertensive patients.

التفاصيل البيبلوغرافية
العنوان:	Single nucleotide polymorphism (SNP) rs4291 of the angiotensin-converting enzyme (ACE) gene is associated with the response to losartan treatment in hypertensive patients.
المؤلفون:	da Cunha Agostini L; Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., de Paula W; Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Melo AS; Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Silva NNT; Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Faria Lopes AC; Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., de Almeida Belo V; Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.; Departamento de Farmácia (DEFAR), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Coura-Vital W; Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.; Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., de Medeiros Teixeira LF; Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Lima AA; Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.; Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., da Silva GN; Programa de Pós-Graduação em Ciências Farmacêuticas (CiPharma), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil. nicioli@ufop.edu.br.; Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Brazil. nicioli@ufop.edu.br.; Departamento de Análises Clínicas (DEACL), Escola de Farmácia, Universidade Federal de Ouro Preto, Morro do Cruzeiro, s/n, Ouro Preto, MG, CEP 35402-163, Brazil. nicioli@ufop.edu.br.
المصدر:	Molecular biology reports [Mol Biol Rep] 2024 Mar 29; Vol. 51 (1), pp. 458. Date of Electronic Publication: 2024 Mar 29.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Dordrecht, Boston, Reidel.
مواضيع طبية MeSH:	Antihypertensive Agents/therapeutic use , Antihypertensive Agents/pharmacology , Hypertension/drug therapy , Hypertension/genetics , Losartan/therapeutic use , Losartan/pharmacology , Peptidyl-Dipeptidase A*/genetics, Humans ; Blood Pressure/genetics ; Case-Control Studies ; Hydrochlorothiazide/therapeutic use ; Hydrochlorothiazide/pharmacology ; Polymorphism, Single Nucleotide/genetics
مستخلص:	Arterial hypertension is characterized by systolic pressure ≥ 140 mmHg and/or diastolic pressure ≥ 90 mmHg and its treatment consists of the use of antihypertensive drugs, as losartan and hydrochlorothiazide. Blood pressure is regulated by angiotensin-converting enzyme (ACE) and polymorphisms in the ACE gene are associated to a greater predisposition to hypertension and response to treatment. The aim of this study was to evaluate the association of genetic polymorphisms of ACE rs4363, rs4291 and rs4335 and the response to antihypertensive drugs in hypertensive patients from Ouro Preto/MG, Brazil. A case-control study was carried out with 87 hypertensive patients being treated with losartan and 75 with hydrochlorothiazide, who answered a questionnaire and had blood samples collected. Biochemical analyzes were performed on serum using UV/Vis spectrophotometry and identification of ACE variants rs4363, rs4291 and rs4335 was performed by real-time PCR using the TaqMan® system. Univariate logistic regression test was performed to compare categorical data in STATA 13.0 software. The results showed that there was an influence of ACE polymorphisms on the response to losartan, demonstrating that AT or TT genotypes of rs4291 were more frequent in the group of controlled AH (54.9%), indicating that these individuals are 2.8 times more likely to of being controlled AH (95% CI 1.12-6.80, p. =0.026) compared to those with AA genotype. In contrast, no influence of ACE polymorphisms on the response to hydrochlorothiazide was observed. In conclusion, the presence of the T allele of the rs4291 variant was associated to controled blood pressure when losartan was used as an antihypertensive agent. These results show the importance of pharmacogenetic studies to detect genetic characteristics, enabling therapeutic individuality and reducing costs for the healthcare system. (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
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معلومات مُعتمدة:	001 Coordination for the Improvement of Higher Education Personnel; 001 Coordination for the Improvement of Higher Education Personnel; 18.295.295/0001-36 Municipal Health Department of Ouro Preto; 23109.016819/2023-81 and 23109.009436/2023-56 Federal University of Ouro Preto; 310905/2020-6 National Council for Scientific and Technological Development (CNPq); APQ-03555-22 Minas Gerais State Research Support Foundation (FAPEMIG)
فهرسة مساهمة:	Keywords: Angiotensin converting enzyme gene; Hydrochlorothiazide; Hypertension; Losartan; Pharmacogenetic
المشرفين على المادة:	0 (Antihypertensive Agents) 0J48LPH2TH (Hydrochlorothiazide) JMS50MPO89 (Losartan) EC 3.4.15.1 (ACE protein, human) EC 3.4.15.1 (Peptidyl-Dipeptidase A)
تواريخ الأحداث:	Date Created: 20240329 Date Completed: 20240401 Latest Revision: 20240405
رمز التحديث:	20240406
DOI:	10.1007/s11033-024-09437-1
PMID:	38551694
قاعدة البيانات:	MEDLINE

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تدمد:	1573-4978
DOI:	10.1007/s11033-024-09437-1