دورية أكاديمية
أعرض في EDS

Maternal separation regulates sensitivity of stress-induced depression in mice by affecting hippocampal metabolism.

التفاصيل البيبلوغرافية
العنوان: Maternal separation regulates sensitivity of stress-induced depression in mice by affecting hippocampal metabolism.
المؤلفون: Zhang Y; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Wang H; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Liu L; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China., Mo X; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., He D; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Chen X; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Faculty of Basic Medicine, Department of Pathology, Chongqing Medical University, Chongqing, 400016, China., Xiao R; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Faculty of Basic Medicine, Department of Pathology, Chongqing Medical University, Chongqing, 400016, China., Cheng Q; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Fatima M; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Du Y; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Xie P; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China. Electronic address: xiepeng@cqmu.edu.cn.
المصدر: Physiology & behavior [Physiol Behav] 2024 May 15; Vol. 279, pp. 114530. Date of Electronic Publication: 2024 Mar 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE
أسماء مطبوعة: Publication: New York NY : Elsevier Science
Original Publication: Oxford, Eng., Long Island City, Pergamon Press.
مواضيع طبية MeSH: Depression*/etiology , Depression*/metabolism , Maternal Deprivation*, Mice ; Animals ; 2-Aminoadipic Acid/metabolism ; 2-Aminoadipic Acid/pharmacology ; Hippocampus/metabolism ; Glycine/pharmacology ; Sucrose/pharmacology ; beta-Alanine/metabolism ; beta-Alanine/pharmacology ; Stress, Psychological/metabolism ; Behavior, Animal/physiology ; Disease Models, Animal
مستخلص: Depression is a serious mental illness. Previous studies found that early life stress (ELS) plays a vital role in the onset and progression of depression. However, relevant studies have not yet been able to explain the specific effects of early stress on stress-induced depression sensitivity and individual behavior during growth. Therefore, we constructed a maternal separation (MS) model and administered chronic social frustration stress at different stages of their growth while conducting metabolomics analysis on the hippocampus of mice. Our results showed that the immobility time of mice in the forced swimming test was significantly reduced at the end of MS. Meanwhile, mice with MS experience significantly decreased total movement distance in the open field test and sucrose preference ratio in the sucrose preference test when subjected to chronic social defeat stress (CSDS) during adolescence. In adulthood, the results were the opposite. In addition, we found that level changes in metabolites such as Beta-alanine, l-aspartic acid, 2-aminoadipic acid, and Glycine are closely related to behavioral changes. These metabolites are mainly enriched in Pantothenate, CoA biosynthesis, and Beta Alanine metabolism pathways. Our experiment revealed that the effects of ELS vary across different age groups. It will increase an individual's sensitivity to depression when facing CSDS in adolescence, but it will reduce their sensitivity to depression when facing CSDS in adulthood. This may be achieved by regulating the hippocampus's Pantothenate and CoA biosynthesis and Beta Alanine metabolism pathways represented by Beta-alanine, l-Aspartic acid, 2-aminoadipic acid, and Glycine metabolites.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Depression; Early life stress; Hippocampus; Maternal separation; Metabolism
المشرفين على المادة: 1K7B1OED4N (2-Aminoadipic Acid)
TE7660XO1C (Glycine)
57-50-1 (Sucrose)
11P2JDE17B (beta-Alanine)
تواريخ الأحداث: Date Created: 20240329 Date Completed: 20240422 Latest Revision: 20240422
رمز التحديث: 20240422
DOI: 10.1016/j.physbeh.2024.114530
PMID: 38552706
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-507X
DOI:10.1016/j.physbeh.2024.114530