دورية أكاديمية
Recurrent central odontogenic fibroma in a patient with nevoid basal cell carcinoma syndrome: case report and in vitro analysis.
العنوان: | Recurrent central odontogenic fibroma in a patient with nevoid basal cell carcinoma syndrome: case report and in vitro analysis. |
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المؤلفون: | Yadav DK; Department of Neurology, University of Alabama at Birmingham, School of Medicine, Birmingham, AL, USA., Smith CM; Oral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA., Zhang AB; Oral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA., DeVilliers P; Department of Pathology, University of Alabama at Birmingham, School of Medicine, Birmingham, AL, USA., Greene SL; Oral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA., Louis PJ; Oral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA., MacDougall M; Oral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA; Faculty of Dentistry, The University of British Columbia, Vancouver, BC, Canada., Amm HM; Oral and Maxillofacial Surgery, University of Alabama at Birmingham, School of Dentistry, Birmingham, AL, USA. Electronic address: hopeamm@uab.edu. |
المصدر: | Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2024 Jul; Vol. 138 (1), pp. e18-e25. Date of Electronic Publication: 2024 Mar 06. |
نوع المنشور: | Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101576782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-4411 (Electronic) NLM ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New York, NY : Elsevier |
مواضيع طبية MeSH: | Basal Cell Nevus Syndrome*/genetics , Basal Cell Nevus Syndrome*/pathology , Odontogenic Tumors*/pathology , Odontogenic Tumors*/genetics , Odontogenic Tumors*/surgery , Neoplasm Recurrence, Local*/pathology , Fibroma*/pathology , Fibroma*/genetics , Fibroma*/surgery, Humans ; Male ; Adult ; Immunohistochemistry ; Mandibular Neoplasms/pathology ; Mandibular Neoplasms/genetics ; Mandibular Neoplasms/surgery ; Real-Time Polymerase Chain Reaction ; In Vitro Techniques |
مستخلص: | Objective: Central odontogenic fibromas (COF) are rare, benign tumors derived from dental mesenchymal tissue that may occur in the maxilla or mandible. This report describes primary and recurrent COF in the mandible of a patient with nevoid basal cell carcinoma syndrome (NBCCS). Study Design: A 36-year-old African American male presented with a COF and its recurrence 17 months later. Tissue pieces were obtained from both occurrences with IRB-approved signed consent. Collected tissue pieces were dissected; one portion was formalin-fixed and paraffin-embedded, and the other was cultured for the isolation of cell populations from the primary (COdF-1) and recurrent (COdF-1a) tumors. Quantification real-time polymerase chain reaction (qRT-PCR), immunohistochemistry, and DNA sequencing were used for gene and protein analysis of the primary tumor and cell populations. Results: Histopathologic analysis of the tumor showed sparse odontogenic epithelial cords in fibrous connective tissue, and qRT-PCR analysis of tumor and cell populations (COdF-1 and COdF-1a) detected VIM, CK14, CD34, CD99 and ALPL mRNA expression. Protein expression was confirmed by immunohistochemistry. CD34 expression in primary tissues was higher than in tumor cells due to tumor vascularization. DNA sequencing indicated the patient had PTCH1 mutations. Conclusions: Histopathology, mRNA, and protein expression indicate the rare occurrence of COF in a patient with mutated PTCH1 gene and NBCCS. (Copyright © 2024. Published by Elsevier Inc.) |
References: | J Neurotrauma. 2009 Aug;26(8):1337-44. (PMID: 19226208) Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jan;125(1):31-43. (PMID: 29104033) Ann Med Surg (Lond). 2015 Dec 01;5:14-8. (PMID: 26793312) Indian J Dent Res. 2013 Nov-Dec;24(6):753-5. (PMID: 24552940) Case Rep Dent. 2015;2015:230297. (PMID: 26457211) J Dent Res. 2005 Sep;84(9):812-6. (PMID: 16109989) J Oral Biol Craniofac Res. 2021 Jul-Sep;11(3):415-422. (PMID: 34094841) J Indian Soc Periodontol. 2014 Mar;18(2):240-3. (PMID: 24872637) SAGE Open Med Case Rep. 2021 Apr 28;9:2050313X211012494. (PMID: 33996090) Int J Oral Sci. 2009 Mar;1(1):34-8. (PMID: 20690502) South Asian J Cancer. 2017 Jul-Sep;6(3):125-128. (PMID: 28975122) J Indian Soc Periodontol. 2014 Jan;18(1):85-7. (PMID: 24744552) Open Dent J. 2015 Jan 06;8:280-8. (PMID: 25646136) Int J Oral Maxillofac Surg. 2011 Nov;40(11):1296-300. (PMID: 21741212) J Oral Pathol Med. 2014 Mar;43(3):183-90. (PMID: 24118390) Indian J Dent. 2015 Oct-Dec;6(4):217-20. (PMID: 26752885) J Med Case Rep. 2012 Jun 12;6:148. (PMID: 22691621) J Bone Oncol. 2020 Nov 18;26:100338. (PMID: 33304804) Case Rep Dent. 2014;2014:642905. (PMID: 25506436) Hum Mutat. 2002 Sep;20(3):233-4. (PMID: 12204003) Hum Pathol. 2013 Jun;44(6):1071-8. (PMID: 23317547) Oral Oncol. 2006 Sep;42(8):757-8. (PMID: 16679047) Cell Commun Signal. 2018 Mar 20;16(1):11. (PMID: 29558958) J Oral Pathol Med. 2013 Mar;42(3):275-80. (PMID: 22882291) Cureus. 2018 Apr 30;10(4):e2556. (PMID: 30038878) Turk Patoloji Derg. 2018;34(1):. (PMID: 28984343) Tex Heart Inst J. 2006;33(1):88-90. (PMID: 16572881) |
معلومات مُعتمدة: | K99 DE023826 United States DE NIDCR NIH HHS; R00 DE023826 United States DE NIDCR NIH HHS; T90 DE022736 United States DE NIDCR NIH HHS |
تواريخ الأحداث: | Date Created: 20240329 Date Completed: 20240621 Latest Revision: 20240805 |
رمز التحديث: | 20240806 |
مُعرف محوري في PubMed: | PMC11193645 |
DOI: | 10.1016/j.oooo.2024.02.015 |
PMID: | 38553309 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2212-4411 |
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DOI: | 10.1016/j.oooo.2024.02.015 |