دورية أكاديمية
Low Mitotic Activity in Papillary Thyroid Cancer: A Marker for Aggressive Features and Recurrence.
| العنوان: | Low Mitotic Activity in Papillary Thyroid Cancer: A Marker for Aggressive Features and Recurrence. |
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| المؤلفون: | Lee-Saxton YJ; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065., Egan CE; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065., Bratton BA; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065., Thiesmeyer JW; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065., Greenberg JA; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065., Marshall TE; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065., Tumati A; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065., Romero-Arenas M; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065., Beninato T; Department of Surgery, Rutgers-Robert Wood Johnson Medical School, Cancer Institute of New Jersey, New Brunswick, NJ., Zarnegar R; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065., Scognamiglio T; Department of Pathology, New York Presbyterian Weill Cornell Medicine, New York, NY USA., Fahey TJ 3rd; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065., Finnerty BM; Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065. |
| المصدر: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Mar 30. Date of Electronic Publication: 2024 Mar 30. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| مستخلص: | Context: The significance of low mitotic activity in papillary thyroid cancer (PTC) is largely undefined. Objective: We aimed to determine the behavioral landscape of PTC with low mitotic activity compared to that of no- and high-mitotic activity. Methods: A single-institution consecutive series of PTC patients from 2018-2022 was reviewed. Mitotic activity was defined as no mitoses, low (1-2 mitoses/2 mm2) or high (≥3 mitoses/2 mm2) per the World Health Organization. The 2015 American Thyroid Association risk stratification was applied to the cohort, and clinicopathologic features were compared between groups. For patients with ≥6 months follow-up, Cox regression analyses for recurrence were performed. Results: 640 PTCs were included - 515 (80.5%) no mitotic activity, 110 (17.2%) low mitotic activity, and 15 (2.3%) high mitotic activity. Overall, low mitotic activity exhibited rates of clinicopathologic features including vascular invasion, gross extrathyroidal extension, and lymph node metastases in between those of no- and high-mitotic activity. PTCs with low mitotic activity had higher rates of intermediate- and high-risk ATA risk stratification compared to those with no mitotic activity (p < 0.001). Low mitotic activity PTCs also had higher recurrence rates (15.5% vs. 4.5%, p < 0.001). Low mitotic activity was associated with recurrence, independent of the ATA risk stratification (HR 2.96; 95% CI 1.28-6.87, p = 0.01). Conclusions: Low mitotic activity is relatively common in PTC and its behavior lies within a spectrum between no- and high-mitotic activity. Given its association with aggressive clinicopathologic features and recurrence, low mitotic activity should be considered when risk stratifying PTC patients for recurrence. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| التعليقات: | Comment in: J Clin Endocrinol Metab. 2024 May 22;:. (PMID: 38776230) |
| فهرسة مساهمة: | Keywords: mitotic activity; papillary thyroid cancer |
| تواريخ الأحداث: | Date Created: 20240330 Latest Revision: 20240522 |
| رمز التحديث: | 20240522 |
| DOI: | 10.1210/clinem/dgae203 |
| PMID: | 38554391 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-7197 |
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| DOI: | 10.1210/clinem/dgae203 |