دورية أكاديمية
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Zeta potential of Z-DNA: A new signature to study B-Z transition in linear and branched DNA.

التفاصيل البيبلوغرافية
العنوان: Zeta potential of Z-DNA: A new signature to study B-Z transition in linear and branched DNA.
المؤلفون: Nial PS; DNA Nanotechnology & Application Laboratory, Environment and Sustainability Department, CSIR-Institute of Minerals & Materials Technology, Bhubaneswar 751013, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad 201002, India., Subudhi U; DNA Nanotechnology & Application Laboratory, Environment and Sustainability Department, CSIR-Institute of Minerals & Materials Technology, Bhubaneswar 751013, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: usubudhi@immt.res.in.
المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 May; Vol. 266 (Pt 1), pp. 131238. Date of Electronic Publication: 2024 Mar 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Guildford, Eng., IPC Science and Technology Press.
مواضيع طبية MeSH: DNA, Z-Form*/chemistry , DNA, B-Form*/chemistry , Nucleic Acid Conformation*, Lanthanum/chemistry ; DNA/chemistry ; Nanostructures/chemistry
مستخلص: Zeta potential is commonly referred as surface charge density and is a key factor in modulating the structural and functional properties of nucleic acids. Although the negative charge density of B-DNA is well understood, there is no prior description of the zeta potential measurement of Z-DNA. In this study, for the first time we discover the zeta potential difference between B-DNA and lanthanum chloride-induced Z-DNA. A series of linear repeat i.e. (CG) n and (GC) n DNA as well as branched DNA (bDNA) structures was used for the B-to-Z DNA transition. Herein, the positive zeta potential of Z-DNA has been demonstrated as a powerful tool to discriminate between B-form and Z-form of DNA. The generality of the approach has been validated both in linear and bDNA nanostructures. Thus, we suggest zeta potential can be used as an ideal signature for the left-handed Z-DNA.
Competing Interests: Declaration of competing interest The authors declare no competing financial interests.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: B-DNA; B-Z DNA transition; DNA nanostructure; DNA nanotechnology; Z-DNA; Zeta potential
المشرفين على المادة: 0 (DNA, Z-Form)
0 (DNA, B-Form)
6I3K30563S (Lanthanum)
9007-49-2 (DNA)
تواريخ الأحداث: Date Created: 20240330 Date Completed: 20240430 Latest Revision: 20240430
رمز التحديث: 20240430
DOI: 10.1016/j.ijbiomac.2024.131238
PMID: 38554916
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0003
DOI:10.1016/j.ijbiomac.2024.131238